| URN | urn:agi-llid:3082 |
|---|---|
| Connectivity | 1331 |
| Name | HGF |
| Description | hepatocyte growth factor (hepapoietin A; scatter factor) |
| Notes | Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq] |
| Pathway | HGFR -> STAT signaling |
|---|---|
| Common Regulators | |
| PPARG Targets | |
| VDR Targets | |
| ERA Pathway |
| Ariadne Ontology | GF |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| protein binding | |
| protein heterodimerization activity | |
| hepatocyte growth factor receptor binding | |
| growth factor activity | |
| serine-type endopeptidase activity |
| GO Cellular Component | extracellular region |
|---|---|
| platelet alpha granule lumen |
| GO Biological Process | negative regulation of apoptosis |
|---|---|
| anti-apoptosis | |
| positive regulation of cell proliferation | |
| activation of MAPK activity | |
| hepatocyte growth factor receptor signaling pathway | |
| cell motion | |
| cell proliferation | |
| mitosis | |
| myoblast proliferation | |
| cell morphogenesis | |
| epithelial to mesenchymal transition | |
| liver development | |
| proteolysis |
| Group | GF |
|---|---|
| extracellular region | |
| platelet alpha granule lumen | |
| catalytic activity | |
| protein binding | |
| protein heterodimerization activity | |
| hepatocyte growth factor receptor binding | |
| growth factor activity | |
| serine-type endopeptidase activity | |
| negative regulation of apoptosis | |
| anti-apoptosis | |
| positive regulation of cell proliferation | |
| activation of MAPK activity | |
| hepatocyte growth factor receptor signaling pathway | |
| cell motion | |
| cell proliferation | |
| mitosis | |
| myoblast proliferation | |
| cell morphogenesis | |
| epithelial to mesenchymal transition | |
| liver development | |
| proteolysis |
| Hugo ID | 4893 |
|---|
| Human chromosome position | 7q21.1 |
|---|
| LocusLink ID | 3082 |
|---|---|
| 15234 | |
| 24446 |
| Alias | SF |
|---|---|
| HGFB | |
| HPTA | |
| F-TCF | |
| hepatocyte growth factor | |
| scatter factor | |
| hepatopoietin A | |
| lung fibroblast-derived mitogen | |
| fibroblast-derived tumor cytotoxic factor | |
| NK1 | |
| NK2 | |
| HGF/SF | |
| SF/HGF | |
| C230052L06Rik | |
| Hepatocyte growth factor (scatter factor) | |
| hepapoietin A | |
| hepatocyte growth factor (hepapoietin A, scatter factor) | |
| Hepatopoeitin A | |
| HGF | |
| hepatocyte growth factor (hepapoietin A; scatter factor) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 142409 |
|---|
| Swiss-Prot Accession | P14210 |
|---|---|
| Q59H59 | |
| Q08048 | |
| Q53WS5 | |
| Q8C9G5 | |
| O55027 | |
| Q8C4E2 | |
| P17945 |
| Unigene ID | Hs.396530 |
|---|---|
| Mm.267078 | |
| Rn.10468 |
| KEGG ID | hsa:3082 |
|---|---|
| mmu:15234 | |
| rno:24446 |
| Swiss-Prot ID | HGF_HUMAN |
|---|---|
| HGF_MOUSE | |
| HGF_RAT | |
| Q53WS5_MOUSE | |
| Q8C9G5_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0003824 |
|---|---|
| 0008083 | |
| 0005515 | |
| 0004252 | |
| 0000187 | |
| 0006916 | |
| 0000902 | |
| 0001837 | |
| 0048012 | |
| 0001889 | |
| 0007067 | |
| 0051450 | |
| 0006508 | |
| 0005576 | |
| 0031093 | |
| 0008283 | |
| 0005171 | |
| 0046982 | |
| 0006928 | |
| 0043066 | |
| 0008284 |
| IPI ID | IPI00025767 |
|---|---|
| IPI00400879 | |
| IPI00400880 | |
| IPI00400881 | |
| IPI00887990 | |
| IPI00400878 | |
| IPI00872431 | |
| IPI00116509 | |
| IPI00230423 | |
| IPI00192939 |
| Mouse chromosome position | 5 4.0 cM |
|---|
| Homologene ID | 503 |
|---|
| MGI ID | 96079 |
|---|
| Rat chromosome position | 4q12 |
|---|
| RGD ID | 2794 |
|---|