| URN | urn:agi-llid:3458 |
|---|---|
| Connectivity | 2895 |
| Name | IFNG |
| Description | interferon, gamma |
| Notes | Interferon-gamma (IFNG), or type II interferon, is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFNG expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFNG in the immune system stems in part from its ability to inhibit viral replication directly, but most importantly derives from its immunostimulatory and immunomodulatory effects. IFNG is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 (MIM 186940) and CD8 (see MIM 186910) cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops (Schoenborn and Wilson, 2007 [PubMed 17981204]).[supplied by OMIM] |
| Pathway | IFNGR -> STAT signaling |
|---|---|
| Common Regulators | |
| RARG Targets | |
| PPARA Targets | |
| PPARG Targets | |
| RORA Targets | |
| VDR Targets | |
| ERA Pathway | |
| Common Regulators and Small Molecules |
| Ariadne Ontology | Cytokine |
|---|
| GO Molecular Function | cytokine activity |
|---|---|
| interferon-gamma receptor binding |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space |
| GO Biological Process | regulation of growth |
|---|---|
| negative regulation of cell proliferation | |
| negative regulation of myelination | |
| negative regulation of smooth muscle cell proliferation | |
| positive regulation of killing of cells of another organism | |
| positive regulation of isotype switching to IgG isotypes | |
| positive regulation of T cell proliferation | |
| positive regulation of tyrosine phosphorylation of Stat1 protein | |
| positive regulation of smooth muscle cell apoptosis | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of chemokine biosynthetic process | |
| positive regulation of interleukin-6 biosynthetic process | |
| positive regulation of interleukin-12 biosynthetic process | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of peptidyl-serine phosphorylation of STAT protein | |
| positive regulation of membrane protein ectodomain proteolysis | |
| positive regulation of MHC class II biosynthetic process | |
| positive regulation of interleukin-12 production | |
| positive regulation of interleukin-1 beta secretion | |
| regulation of insulin secretion | |
| regulation of transcription | |
| cell surface receptor linked signal transduction | |
| endoplasmic reticulum unfolded protein response | |
| tyrosine phosphorylation of Stat1 protein | |
| regulation of immune response | |
| neutrophil apoptosis | |
| cell motion | |
| cell cycle arrest | |
| inflammatory cell apoptosis | |
| neutrophil chemotaxis | |
| protein import into nucleus, translocation | |
| antigen processing and presentation | |
| immune response | |
| response to virus | |
| defense response to bacterium |
| Group | Cytokine |
|---|---|
| extracellular region | |
| extracellular space | |
| cytokine activity | |
| interferon-gamma receptor binding | |
| regulation of growth | |
| negative regulation of cell proliferation | |
| negative regulation of myelination | |
| negative regulation of smooth muscle cell proliferation | |
| positive regulation of killing of cells of another organism | |
| positive regulation of isotype switching to IgG isotypes | |
| positive regulation of T cell proliferation | |
| positive regulation of tyrosine phosphorylation of Stat1 protein | |
| positive regulation of smooth muscle cell apoptosis | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of chemokine biosynthetic process | |
| positive regulation of interleukin-6 biosynthetic process | |
| positive regulation of interleukin-12 biosynthetic process | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of peptidyl-serine phosphorylation of STAT protein | |
| positive regulation of membrane protein ectodomain proteolysis | |
| positive regulation of MHC class II biosynthetic process | |
| positive regulation of interleukin-12 production | |
| positive regulation of interleukin-1 beta secretion | |
| regulation of insulin secretion | |
| regulation of transcription | |
| cell surface receptor linked signal transduction | |
| endoplasmic reticulum unfolded protein response | |
| tyrosine phosphorylation of Stat1 protein | |
| regulation of immune response | |
| neutrophil apoptosis | |
| cell motion | |
| cell cycle arrest | |
| inflammatory cell apoptosis | |
| neutrophil chemotaxis | |
| protein import into nucleus, translocation | |
| antigen processing and presentation | |
| immune response | |
| response to virus | |
| defense response to bacterium |
| Hugo ID | 5438 |
|---|
| Human chromosome position | 12q14 |
|---|
| LocusLink ID | 3458 |
|---|---|
| 15978 | |
| 25712 |
| Alias | IFG |
|---|---|
| IFI | |
| interferon, gamma | |
| IFN-g | |
| IFN-gamma | |
| interferon gamma | |
| gamma interferon | |
| IFNG2 | |
| IFNgamma | |
| gamma IFN | |
| IFNG | |
| Immune interferon | |
| ING_HUMAN |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 147570 |
|---|---|
| 609423 | |
| 609532 | |
| 609135 | |
| 191100 | |
| 607948 |
| Swiss-Prot Accession | B5BU88 |
|---|---|
| P01579 | |
| Q14609 | |
| Q14610 | |
| Q14611 | |
| Q14612 | |
| Q14613 | |
| Q14614 | |
| Q14615 | |
| Q53ZV4 | |
| Q8NHY9 | |
| Q96LA2 | |
| P01580 | |
| Q6TDH0 | |
| P01581 |
| Unigene ID | Hs.856 |
|---|---|
| Mm.240327 | |
| Rn.10795 |
| KEGG ID | hsa:3458 |
|---|---|
| mmu:15978 | |
| rno:25712 |
| Swiss-Prot ID | IFNG_HUMAN |
|---|---|
| IFNG_MOUSE | |
| IFNG_RAT | |
| B5BU88_HUMAN |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005125 |
|---|---|
| 0005133 | |
| 0019882 | |
| 0007050 | |
| 0006928 | |
| 0007166 | |
| 0042742 | |
| 0030968 | |
| 0006925 | |
| 0031642 | |
| 0048662 | |
| 0001781 | |
| 0030593 | |
| 0045348 | |
| 0045080 | |
| 0050718 | |
| 0045084 | |
| 0032735 | |
| 0045410 | |
| 0048304 | |
| 0051712 | |
| 0051044 | |
| 0045429 | |
| 0034393 | |
| 0045893 | |
| 0000060 | |
| 0040008 | |
| 0050776 | |
| 0050796 | |
| 0045449 | |
| 0009615 | |
| 0042508 | |
| 0005576 | |
| 0005615 | |
| 0006955 | |
| 0042102 | |
| 0033141 | |
| 0042511 | |
| 0008285 |
| IPI ID | IPI00307209 |
|---|---|
| IPI00136892 | |
| IPI00214504 |
| Mouse chromosome position | 10 67.0 cM |
|---|
| Homologene ID | 55526 |
|---|
| MGI ID | 107656 |
|---|
| Rat chromosome position | 7q22 |
|---|
| RGD ID | 2866 |
|---|