| URN | urn:agi-llid:4846 |
|---|---|
| Connectivity | 1142 |
| Name | NOS3 |
| Description | nitric oxide synthase 3 (endothelial cell) |
| Notes | Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. [provided by RefSeq] |
| Pathway | PPARA Targets |
|---|---|
| PPARG Targets | |
| FXR Targets | |
| ERA Pathway | |
| ERB Targets | |
| MR Target Genes | |
| PGR Targets | |
| NR5A1 Targets | |
| LRH1 Targets |
| Ariadne Ontology | NO biosyntheis |
|---|---|
| NOS |
| GO Molecular Function | electron carrier activity |
|---|---|
| protein binding | |
| arginine binding | |
| NADP or NADPH binding | |
| tetrahydrobiopterin binding | |
| FAD binding | |
| FMN binding | |
| metal ion binding | |
| calcium ion binding | |
| cadmium ion binding | |
| zinc ion binding | |
| iron ion binding | |
| heme binding | |
| calmodulin binding | |
| actin monomer binding | |
| oxidoreductase activity | |
| nitric-oxide synthase activity |
| GO Cellular Component | membrane |
|---|---|
| apical part of cell | |
| soluble fraction | |
| Golgi membrane | |
| cytoplasm | |
| cytosol | |
| Golgi apparatus | |
| nucleus | |
| nucleolus | |
| cytoskeleton | |
| plasma membrane | |
| caveola |
| GO Biological Process | angiogenesis |
|---|---|
| positive regulation of angiogenesis | |
| negative regulation of platelet activation | |
| anti-apoptosis | |
| negative regulation of smooth muscle cell proliferation | |
| negative regulation of muscle hyperplasia | |
| negative regulation of potassium ion transport | |
| negative regulation of calcium ion transport | |
| positive regulation of vasodilation | |
| signal transduction | |
| positive regulation of guanylate cyclase activity | |
| lipopolysaccharide-mediated signaling pathway | |
| regulation of sodium ion transport | |
| regulation of blood pressure | |
| regulation of systemic arterial blood pressure by endothelin | |
| regulation of blood vessel size | |
| negative regulation of hydrolase activity | |
| endothelial cell migration | |
| mitochondrion organization | |
| arginine catabolic process | |
| nitric oxide biosynthetic process | |
| aging | |
| blood vessel remodeling | |
| lung development | |
| ovulation from ovarian follicle | |
| oxidation reduction | |
| response to lipopolysaccharide | |
| smooth muscle hyperplasia | |
| response to heat | |
| response to drug | |
| response to cytokine stimulus | |
| response to amino acid stimulus | |
| response to peptide hormone stimulus | |
| response to estradiol stimulus | |
| response to lead ion | |
| response to lipoprotein stimulus | |
| response to ethanol | |
| response to organic cyclic substance | |
| response to hyperoxia | |
| response to hypoxia | |
| response to fluid shear stress |
| Group | NO biosyntheis |
|---|---|
| NOS | |
| membrane | |
| apical part of cell | |
| soluble fraction | |
| Golgi membrane | |
| cytoplasm | |
| cytosol | |
| Golgi apparatus | |
| nucleus | |
| nucleolus | |
| cytoskeleton | |
| plasma membrane | |
| caveola | |
| electron carrier activity | |
| protein binding | |
| arginine binding | |
| NADP or NADPH binding | |
| tetrahydrobiopterin binding | |
| FAD binding | |
| FMN binding | |
| metal ion binding | |
| calcium ion binding | |
| cadmium ion binding | |
| zinc ion binding | |
| iron ion binding | |
| heme binding | |
| calmodulin binding | |
| actin monomer binding | |
| oxidoreductase activity | |
| nitric-oxide synthase activity | |
| angiogenesis | |
| positive regulation of angiogenesis | |
| negative regulation of platelet activation | |
| anti-apoptosis | |
| negative regulation of smooth muscle cell proliferation | |
| negative regulation of muscle hyperplasia | |
| negative regulation of potassium ion transport | |
| negative regulation of calcium ion transport | |
| positive regulation of vasodilation | |
| signal transduction | |
| positive regulation of guanylate cyclase activity | |
| lipopolysaccharide-mediated signaling pathway | |
| regulation of sodium ion transport | |
| regulation of blood pressure | |
| regulation of systemic arterial blood pressure by endothelin | |
| regulation of blood vessel size | |
| negative regulation of hydrolase activity | |
| endothelial cell migration | |
| mitochondrion organization | |
| arginine catabolic process | |
| nitric oxide biosynthetic process | |
| aging | |
| blood vessel remodeling | |
| lung development | |
| ovulation from ovarian follicle | |
| oxidation reduction | |
| response to lipopolysaccharide | |
| smooth muscle hyperplasia | |
| response to heat | |
| response to drug | |
| response to cytokine stimulus | |
| response to amino acid stimulus | |
| response to peptide hormone stimulus | |
| response to estradiol stimulus | |
| response to lead ion | |
| response to lipoprotein stimulus | |
| response to ethanol | |
| response to organic cyclic substance | |
| response to hyperoxia | |
| response to hypoxia | |
| response to fluid shear stress |
| Hugo ID | 7876 |
|---|
| Human chromosome position | 7q36 |
|---|
| LocusLink ID | 4846 |
|---|---|
| 18127 | |
| 24600 |
| Alias | eNOS |
|---|---|
| ECNOS | |
| nitric oxide synthase 3 (endothelial cell) | |
| endothelial nitric oxidase synthase | |
| Nos-3 | |
| 2310065A03Rik | |
| OTTMUSP00000028591 | |
| endothelial nitric oxide synthase | |
| endothelial nitric oxide synthase 3 | |
| cNOS | |
| EC-NOS | |
| Endothelial NOS | |
| nitric oxide synthase 3 | |
| Nitric-oxide synthase, endothelial | |
| NOS, type III | |
| Nos3 | |
| NOSIII | |
| RIKEN cDNA 2310065A03 gene | |
| Endothelial nitric oxide synthase III | |
| nitric oxide synthase III | |
| NOS3L | |
| nitric oxide synthase 3, endothelial cell | |
| nitric oxide synthase 3-like |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 163729 |
|---|---|
| 104300 | |
| 189800 | |
| 145500 | |
| 601367 |
| Swiss-Prot Accession | P29474 |
|---|---|
| O14937 | |
| Q548C1 | |
| Q96J98 | |
| Q96P37 | |
| Q9UDC6 | |
| Q7TSV7 | |
| Q8C5P3 | |
| P70313 | |
| Q9WTY7 | |
| Q62600 | |
| Q9JJY7 | |
| Q9Z1P9 |
| Unigene ID | Hs.647092 |
|---|---|
| Mm.258415 | |
| Rn.44265 |
| KEGG ID | hsa:4846 |
|---|---|
| mmu:18127 | |
| rno:24600 |
| EC Number | 1.14.13.39 |
|---|
| Swiss-Prot ID | NOS3_HUMAN |
|---|---|
| NOS3_RAT | |
| Q7TSV7_MOUSE | |
| Q8C5P3_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0050660 |
|---|---|
| 0010181 | |
| 0050661 | |
| 0003785 | |
| 0034618 | |
| 0046870 | |
| 0005509 | |
| 0005516 | |
| 0009055 | |
| 0020037 | |
| 0004517 | |
| 0016491 | |
| 0034617 | |
| 0008270 | |
| 0006916 | |
| 0006527 | |
| 0001974 | |
| 0043542 | |
| 0031663 | |
| 0030324 | |
| 0007005 | |
| 0051926 | |
| 0051346 | |
| 0014740 | |
| 0010544 | |
| 0043267 | |
| 0048662 | |
| 0006809 | |
| 0001542 | |
| 0055114 | |
| 0045766 | |
| 0031284 | |
| 0045909 | |
| 0008217 | |
| 0050880 | |
| 0002028 | |
| 0003100 | |
| 0034405 | |
| 0009408 | |
| 0007165 | |
| 0014806 | |
| 0005794 | |
| 0000139 | |
| 0045177 | |
| 0005901 | |
| 0005737 | |
| 0005856 | |
| 0005829 | |
| 0005634 | |
| 0005886 | |
| 0005625 | |
| 0005506 | |
| 0046872 | |
| 0001525 | |
| 0016020 | |
| 0005515 | |
| 0007568 | |
| 0043200 | |
| 0034097 | |
| 0042493 | |
| 0032355 | |
| 0045471 | |
| 0055093 | |
| 0001666 | |
| 0010288 | |
| 0032496 | |
| 0055094 | |
| 0014070 | |
| 0043434 | |
| 0005730 |
| IPI ID | IPI00218845 |
|---|---|
| IPI00555127 | |
| IPI00311671 | |
| IPI00858057 | |
| IPI00206975 |
| Mouse chromosome position | 5 9.0 cM |
|---|
| Homologene ID | 504 |
|---|
| MGI ID | 97362 |
|---|
| Rat chromosome position | 4q11 |
|---|
| RGD ID | 3186 |
|---|