| URN | urn:agi-llid:6356 |
|---|---|
| Connectivity | 348 |
| Name | CCL11 |
| Description | chemokine (C-C motif) ligand 11 |
| Notes | This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil specific chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq] |
| Pathway | CCR5 -> TP53 signaling |
|---|---|
| CCR2/5 -> STAT signaling | |
| PPARG Targets | |
| GR Targets |
| Ariadne Ontology | Chemokines |
|---|
| GO Molecular Function | molecular_function |
|---|---|
| cytokine activity | |
| chemokine activity |
| GO Cellular Component | cellular_component |
|---|---|
| extracellular region | |
| extracellular space |
| GO Biological Process | biological_process |
|---|---|
| cell adhesion | |
| signal transduction | |
| cellular calcium ion homeostasis | |
| protein amino acid phosphorylation | |
| immune response | |
| chemotaxis | |
| response to virus | |
| response to radiation | |
| inflammatory response |
| Group | Chemokines |
|---|---|
| cellular_component | |
| extracellular region | |
| extracellular space | |
| molecular_function | |
| cytokine activity | |
| chemokine activity | |
| biological_process | |
| cell adhesion | |
| signal transduction | |
| cellular calcium ion homeostasis | |
| protein amino acid phosphorylation | |
| immune response | |
| chemotaxis | |
| response to virus | |
| response to radiation | |
| inflammatory response |
| Hugo ID | 10610 |
|---|
| Human chromosome position | 17q21.1-q21.2 |
|---|
| LocusLink ID | 6356 |
|---|---|
| 20292 | |
| 29397 |
| Alias | SCYA11 |
|---|---|
| MGC22554 | |
| small inducible cytokine A11 | |
| eotaxin | |
| eosinophil chemotactic protein | |
| small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin) | |
| small chemokine (C-C motif) ligand 11 | |
| OTTMUSP00000000791 | |
| small inducible cytokine subfamily A11 | |
| Eotaxin precursors | |
| Small inducible cytokine A11 (eotaxin) | |
| chemokine (C-C motif) ligand 11 | |
| Ccl11 | |
| EOTA | |
| small inducible cytokine A11 precursor | |
| small inducible cytokine subfamily A (Cys-Cys), member 11 | |
| EOTA_HUMAN | |
| Eosinophil chemotactic factor | |
| SCYA11s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601156 |
|---|---|
| 600807 | |
| 609423 |
| Swiss-Prot Accession | P51671 |
|---|---|
| Q6I9T4 | |
| B1AT07 | |
| P48298 | |
| P97545 |
| Unigene ID | Hs.54460 |
|---|---|
| Mm.4686 | |
| Rn.10632 |
| KEGG ID | hsa:6356 |
|---|---|
| mmu:20292 | |
| rno:29397 |
| Swiss-Prot ID | CCL11_HUMAN |
|---|---|
| CCL11_MOUSE | |
| CCL11_RAT | |
| Q6I9T4_HUMAN | |
| B1AT07_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0008009 |
|---|---|
| 0007155 | |
| 0006874 | |
| 0006935 | |
| 0006955 | |
| 0006954 | |
| 0006468 | |
| 0009314 | |
| 0009615 | |
| 0007165 | |
| 0005576 | |
| 0005615 | |
| 0005125 | |
| 0003674 | |
| 0008150 | |
| 0005575 |
| IPI ID | IPI00019945 |
|---|---|
| IPI00110013 | |
| IPI00205491 |
| Mouse chromosome position | 11 47.0 cM |
|---|
| Homologene ID | 7929 |
|---|
| MGI ID | 103576 |
|---|
| Rat chromosome position | 10q26 |
|---|
| RGD ID | 3644 |
|---|