| URN | urn:agi-llid:958 |
|---|---|
| Connectivity | 1013 |
| Name | CD40 |
| Description | CD40 molecule, TNF receptor superfamily member 5 |
| Notes | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq] |
| Pathway | TNFRSF5/13B -> NFATC1 signaling |
|---|---|
| TNFRSF5 -> STAT signaling | |
| TNFR -> NF-kB signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFRSF5/6 -> RB1/E2F signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| Common Regulators | |
| PPARG Targets | |
| Common Regulators and Small Molecules |
| Ariadne Ontology | TNFR |
|---|
| GO Molecular Function | molecular_function |
|---|---|
| protein binding | |
| enzyme binding | |
| receptor activity | |
| transmembrane receptor activity |
| GO Cellular Component | cellular_component |
|---|---|
| extracellular region | |
| membrane | |
| external side of plasma membrane | |
| intracellular membrane-bounded organelle | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | protein complex assembly |
|---|---|
| positive regulation of B cell proliferation | |
| positive regulation of isotype switching to IgG isotypes | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of interleukin-12 production | |
| signal transduction | |
| regulation of immunoglobulin secretion | |
| immune response-regulating cell surface receptor signaling pathway | |
| regulation of immune response | |
| platelet activation | |
| B cell activation | |
| B cell proliferation | |
| apoptosis | |
| immune response | |
| inflammatory response |
| Group | TNFR |
|---|---|
| cellular_component | |
| extracellular region | |
| membrane | |
| external side of plasma membrane | |
| intracellular membrane-bounded organelle | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| molecular_function | |
| protein binding | |
| enzyme binding | |
| receptor activity | |
| transmembrane receptor activity | |
| protein complex assembly | |
| positive regulation of B cell proliferation | |
| positive regulation of isotype switching to IgG isotypes | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of interleukin-12 production | |
| signal transduction | |
| regulation of immunoglobulin secretion | |
| immune response-regulating cell surface receptor signaling pathway | |
| regulation of immune response | |
| platelet activation | |
| B cell activation | |
| B cell proliferation | |
| apoptosis | |
| immune response | |
| inflammatory response |
| Hugo ID | 11919 |
|---|
| Human chromosome position | 20q12-q13.2 |
|---|
| LocusLink ID | 958 |
|---|---|
| 21939 | |
| 171369 |
| Alias | p50 |
|---|---|
| Bp50 | |
| CDW40 | |
| MGC9013 | |
| TNFRSF5 | |
| CD40 antigen | |
| CD40L receptor | |
| OTTHUMP00000031699 | |
| OTTHUMP00000031700 | |
| CD40 type II isoform | |
| B cell-associated molecule | |
| B cell surface antigen CD40 | |
| CD40 antigen (TNF receptor superfamily member 5) | |
| tumor necrosis factor receptor superfamily, member 5 | |
| nerve growth factor receptor-related B-lymphocyte activation molecule | |
| IGM | |
| GP39 | |
| IMD3 | |
| TRAP | |
| HIGM1 | |
| T-BAM | |
| AI326936 | |
| RP23-428M13.1 | |
| OTTMUSP00000017667 | |
| OTTMUSP00000017739 | |
| T-cell differentiation antigen | |
| CD40 molecule, TNF receptor superfamily member 5 | |
| CD40 antigen, TNF receptor superfamily member 5 | |
| B-cell surface antigen CD40 | |
| CD40L receptor | |
| TNF receptor 5 | |
| TNR5 | |
| Tumor necrosis factor receptor superfamily, member 5 (CD40 antigen) | |
| B-cell activation CD40 | |
| TNR5_HUMAN | |
| TNF receptor V | |
| tumor necrosis factor receptor superfamily, member V | |
| CD40 | |
| nerve growth factor receptor-related B-lymphocyte activating molecule | |
| CD40L receptors | |
| LOC194051 | |
| LOC228872 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 109535 |
|---|---|
| 606843 |
| Swiss-Prot Accession | P25942 |
|---|---|
| Q09LL4 | |
| Q59F01 | |
| Q6P2H9 | |
| P27512 | |
| A2A5L5 | |
| Q4QQW2 | |
| Q9JKE0 |
| Unigene ID | Hs.472860 |
|---|---|
| Mm.271833 | |
| Rn.25180 |
| KEGG ID | hsa:958 |
|---|---|
| mmu:21939 | |
| rno:171369 |
| Swiss-Prot ID | TNR5_HUMAN |
|---|---|
| TNR5_MOUSE | |
| A2A5L5_MOUSE | |
| Q4QQW2_RAT |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0019899 |
|---|---|
| 0004888 | |
| 0042100 | |
| 0006915 | |
| 0006955 | |
| 0006954 | |
| 0030168 | |
| 0043123 | |
| 0006461 | |
| 0007165 | |
| 0005576 | |
| 0005887 | |
| 0005886 | |
| 0005515 | |
| 0004872 | |
| 0042113 | |
| 0002768 | |
| 0030890 | |
| 0032735 | |
| 0048304 | |
| 0050776 | |
| 0051023 | |
| 0009897 | |
| 0016021 | |
| 0043231 | |
| 0016020 | |
| 0003674 | |
| 0005575 |
| IPI ID | IPI00018282 |
|---|---|
| IPI00218464 | |
| IPI00556230 | |
| IPI00440178 | |
| IPI00117572 | |
| IPI00230174 | |
| IPI00230175 | |
| IPI00845784 | |
| IPI00230176 | |
| IPI00757148 | |
| IPI00553966 | |
| IPI00778403 | |
| IPI00776841 |
| Mouse chromosome position | 2 97.0 cM |
|---|
| Homologene ID | 954 |
|---|
| MGI ID | 88336 |
|---|
| Rat chromosome position | 3q42 |
|---|
| RGD ID | 619830 |
|---|