| URN | urn:agi-llid:3569 |
|---|---|
| Connectivity | 3074 |
| Name | IL6 |
| Description | interleukin 6 (interferon, beta 2) |
| Notes | This gene encodes a cytokine that functions in inflammation and the maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq] |
| Pathway | IL6R -> CEBP/ELK-SRF signaling |
|---|---|
| IL6R -> STAT signaling | |
| IL6ST -> STAT5B signaling | |
| Common Regulators | |
| PPARA Targets | |
| PPARD Targets | |
| PPARG Targets | |
| NR1D1 Targets | |
| RORA Targets | |
| LXRA Targets | |
| FXR Targets | |
| NURR1 Targets | |
| ERA Pathway | |
| ERB Targets | |
| GR Targets | |
| MR Target Genes | |
| TR3 Targets | |
| NR4A3 Targets | |
| Common Regulators and Small Molecules |
| Ariadne Ontology | Cytokine |
|---|
| GO Molecular Function | protein binding |
|---|---|
| growth factor activity | |
| cytokine activity | |
| interleukin-6 receptor binding |
| GO Cellular Component | extracellular region |
|---|---|
| external side of plasma membrane | |
| interleukin-6 receptor complex | |
| extracellular space |
| GO Biological Process | regulation of angiogenesis |
|---|---|
| negative regulation of cell proliferation | |
| negative regulation of hormone secretion | |
| negative regulation of apoptosis | |
| positive regulation of anti-apoptosis | |
| negative regulation of chemokine biosynthetic process | |
| negative regulation of collagen biosynthetic process | |
| positive regulation of B cell activation | |
| positive regulation of T-helper 2 cell differentiation | |
| positive regulation of T cell proliferation | |
| positive regulation of MAPKKK cascade | |
| positive regulation of JAK-STAT cascade | |
| positive regulation of tyrosine phosphorylation of Stat3 protein | |
| positive regulation of osteoblast differentiation | |
| positive regulation of leukocyte chemotaxis | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of translation | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of interleukin-6 production | |
| positive regulation of chemokine production | |
| positive regulation of acute inflammatory response | |
| positive regulation of immunoglobulin secretion | |
| regulation of cell proliferation | |
| positive regulation of NF-kappaB transcription factor activity | |
| interleukin-6-mediated signaling pathway | |
| regulation of circadian sleep-wake cycle, non-REM sleep | |
| regulation of vascular endothelial growth factor production | |
| muscle maintenance | |
| neutrophil apoptosis | |
| platelet activation | |
| peptide hormone secretion | |
| monocyte chemotaxis | |
| neuron projection development | |
| endocrine pancreas development | |
| salivary gland morphogenesis | |
| immune response | |
| defense response to virus | |
| neutrophil mediated immunity | |
| humoral immune response | |
| hepatic immune response | |
| defense response to Gram-positive bacterium | |
| defense response to Gram-negative bacterium | |
| response to peptidoglycan | |
| defense response to protozoan | |
| response to mechanical stimulus | |
| response to glucocorticoid stimulus | |
| inflammatory response | |
| acute-phase response |
| Group | Cytokine |
|---|---|
| extracellular region | |
| external side of plasma membrane | |
| interleukin-6 receptor complex | |
| extracellular space | |
| protein binding | |
| growth factor activity | |
| cytokine activity | |
| interleukin-6 receptor binding | |
| regulation of angiogenesis | |
| negative regulation of cell proliferation | |
| negative regulation of hormone secretion | |
| negative regulation of apoptosis | |
| positive regulation of anti-apoptosis | |
| negative regulation of chemokine biosynthetic process | |
| negative regulation of collagen biosynthetic process | |
| positive regulation of B cell activation | |
| positive regulation of T-helper 2 cell differentiation | |
| positive regulation of T cell proliferation | |
| positive regulation of MAPKKK cascade | |
| positive regulation of JAK-STAT cascade | |
| positive regulation of tyrosine phosphorylation of Stat3 protein | |
| positive regulation of osteoblast differentiation | |
| positive regulation of leukocyte chemotaxis | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of translation | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of interleukin-6 production | |
| positive regulation of chemokine production | |
| positive regulation of acute inflammatory response | |
| positive regulation of immunoglobulin secretion | |
| regulation of cell proliferation | |
| positive regulation of NF-kappaB transcription factor activity | |
| interleukin-6-mediated signaling pathway | |
| regulation of circadian sleep-wake cycle, non-REM sleep | |
| regulation of vascular endothelial growth factor production | |
| muscle maintenance | |
| neutrophil apoptosis | |
| platelet activation | |
| peptide hormone secretion | |
| monocyte chemotaxis | |
| neuron projection development | |
| endocrine pancreas development | |
| salivary gland morphogenesis | |
| immune response | |
| defense response to virus | |
| neutrophil mediated immunity | |
| humoral immune response | |
| hepatic immune response | |
| defense response to Gram-positive bacterium | |
| defense response to Gram-negative bacterium | |
| response to peptidoglycan | |
| defense response to protozoan | |
| response to mechanical stimulus | |
| response to glucocorticoid stimulus | |
| inflammatory response | |
| acute-phase response |
| Hugo ID | 6018 |
|---|
| Human chromosome position | 7p21 |
|---|
| LocusLink ID | 3569 |
|---|---|
| 16193 | |
| 24498 |
| Alias | HGF |
|---|---|
| HSF | |
| BSF2 | |
| IL-6 | |
| IFNB2 | |
| interleukin 6 | |
| interleukin BSF-2 | |
| hybridoma growth factor | |
| CTL differentiation factor | |
| B cell stimulatory factor-2 | |
| B-cell differentiation factor | |
| ILg6 | |
| Interleukin 6 (interferon, beta 2) | |
| IL6_HUMAN | |
| Interferon beta-2 | |
| interleukin VI | |
| interlukin 6 | |
| Interleukin-IL6 | |
| Interferon beta II | |
| IL6 | |
| B-cell stimulatory factor II | |
| B-cell stimulatory factor 2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 147620 |
|---|---|
| 266600 | |
| 125853 | |
| 108010 | |
| 148000 | |
| 166710 | |
| 604302 |
| Swiss-Prot Accession | P05231 |
|---|---|
| Q75MH2 | |
| Q8N6X1 | |
| A2RTD1 | |
| P08505 | |
| Q0PMN1 | |
| Q3U8J8 | |
| P20607 |
| Unigene ID | Hs.654458 |
|---|---|
| Mm.1019 | |
| Rn.9873 |
| KEGG ID | hsa:3569 |
|---|---|
| mmu:16193 | |
| rno:24498 |
| Swiss-Prot ID | IL6_HUMAN |
|---|---|
| IL6_MOUSE | |
| IL6_RAT | |
| Q75MH2_HUMAN | |
| A2RTD1_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005125 |
|---|---|
| 0005138 | |
| 0006953 | |
| 0050829 | |
| 0050830 | |
| 0051607 | |
| 0031018 | |
| 0002384 | |
| 0006959 | |
| 0006954 | |
| 0070102 | |
| 0002548 | |
| 0043066 | |
| 0008285 | |
| 0045079 | |
| 0032966 | |
| 0031175 | |
| 0001781 | |
| 0002446 | |
| 0030072 | |
| 0030168 | |
| 0050871 | |
| 0046427 | |
| 0043410 | |
| 0051092 | |
| 0042102 | |
| 0002675 | |
| 0045768 | |
| 0032722 | |
| 0051024 | |
| 0032755 | |
| 0002690 | |
| 0045669 | |
| 0033138 | |
| 0050731 | |
| 0048661 | |
| 0045944 | |
| 0045727 | |
| 0042517 | |
| 0045765 | |
| 0010574 | |
| 0051384 | |
| 0032494 | |
| 0005576 | |
| 0005615 | |
| 0005896 | |
| 0008083 | |
| 0005515 | |
| 0042832 | |
| 0006955 | |
| 0046716 | |
| 0046888 | |
| 0045630 | |
| 0050679 | |
| 0045893 | |
| 0042127 | |
| 0007435 | |
| 0009897 | |
| 0045188 | |
| 0009612 |
| IPI ID | IPI00007793 |
|---|---|
| IPI00878107 | |
| IPI00167115 | |
| IPI00878334 | |
| IPI00878660 | |
| IPI00877815 | |
| IPI00877634 | |
| IPI00133702 | |
| IPI00201260 |
| Mouse chromosome position | 5 17.0 cM |
|---|
| Homologene ID | 502 |
|---|
| MGI ID | 96559 |
|---|
| Rat chromosome position | 4q11 |
|---|
| RGD ID | 2901 |
|---|