| URN | urn:agi-llid:7124 |
|---|---|
| Connectivity | 4196 |
| Name | TNF |
| Description | tumor necrosis factor (TNF superfamily, member 2) |
| Notes | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq] |
| Pathway | TNFR -> NF-kB signaling |
|---|---|
| TNFRSF1A -> STAT signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> CREB/ELK-SRF signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| Common Regulators | |
| PPARA Targets | |
| PPARD Targets | |
| PPARG Targets | |
| LXRA Targets | |
| FXR Targets | |
| ERA Pathway | |
| NR5A1 Targets |
| Ariadne Ontology | TNF family |
|---|
| GO Molecular Function | identical protein binding |
|---|---|
| cytokine activity | |
| tumor necrosis factor receptor binding |
| GO Cellular Component | extracellular region |
|---|---|
| membrane | |
| external side of plasma membrane | |
| secretory granule | |
| recycling endosome | |
| plasma membrane | |
| membrane raft | |
| integral to membrane | |
| integral to plasma membrane | |
| phagocytic cup | |
| extracellular space |
| GO Biological Process | positive regulation of heterotypic cell-cell adhesion |
|---|---|
| leukocyte tethering or rolling | |
| negative regulation of cell proliferation | |
| anti-apoptosis | |
| negative regulation of transcription | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of lipid catabolic process | |
| negative regulation of interleukin-6 production | |
| negative regulation of L-glutamate transport | |
| negative regulation of glucose import | |
| negative regulation of cytokine secretion during immune response | |
| negative regulation of viral genome replication | |
| positive regulation of cell proliferation | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of JNK cascade | |
| positive regulation of synaptic transmission | |
| positive regulation of mitosis | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| induction of apoptosis by extracellular signals | |
| induction of apoptosis via death domain receptors | |
| positive regulation of neuron apoptosis | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of transcription | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of chemokine biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription | |
| positive regulation of translational initiation by iron | |
| positive regulation of protein amino acid phosphorylation | |
| positive regulation of membrane protein ectodomain proteolysis | |
| positive regulation of hair follicle development | |
| positive regulation of interleukin-18 production | |
| positive regulation of chemokine production | |
| positive regulation of inflammatory response | |
| positive regulation of protein transport | |
| positive regulation of NF-kappaB import into nucleus | |
| positive regulation of cytokine secretion | |
| signal transduction | |
| regulation of cell proliferation | |
| regulation of insulin secretion | |
| activation of caspase activity | |
| regulation of osteoclast differentiation | |
| regulation of immunoglobulin secretion | |
| positive regulation of NF-kappaB transcription factor activity | |
| regulation of protein amino acid phosphorylation | |
| activation of MAPK activity | |
| tumor necrosis factor-mediated signaling pathway | |
| JNK cascade | |
| calcium-mediated signaling | |
| sequestering of triglyceride | |
| cell activation | |
| cell proliferation | |
| apoptosis | |
| transformed cell apoptosis | |
| leukocyte migration | |
| cellular extravasation | |
| osteoclast differentiation | |
| protein import into nucleus, translocation | |
| glucose metabolic process | |
| multicellular organismal development | |
| organ morphogenesis | |
| immune response | |
| humoral immune response | |
| chronic inflammatory response to antigenic stimulus | |
| receptor biosynthetic process | |
| response to virus | |
| defense response to bacterium | |
| response to mechanical stimulus | |
| response to salt stress | |
| response to glucocorticoid stimulus | |
| inflammatory response | |
| defense response |
| Group | TNF family |
|---|---|
| extracellular region | |
| membrane | |
| external side of plasma membrane | |
| secretory granule | |
| recycling endosome | |
| plasma membrane | |
| membrane raft | |
| integral to membrane | |
| integral to plasma membrane | |
| phagocytic cup | |
| extracellular space | |
| identical protein binding | |
| cytokine activity | |
| tumor necrosis factor receptor binding | |
| positive regulation of heterotypic cell-cell adhesion | |
| leukocyte tethering or rolling | |
| negative regulation of cell proliferation | |
| anti-apoptosis | |
| negative regulation of transcription | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of lipid catabolic process | |
| negative regulation of interleukin-6 production | |
| negative regulation of L-glutamate transport | |
| negative regulation of glucose import | |
| negative regulation of cytokine secretion during immune response | |
| negative regulation of viral genome replication | |
| positive regulation of cell proliferation | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of JNK cascade | |
| positive regulation of synaptic transmission | |
| positive regulation of mitosis | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| induction of apoptosis by extracellular signals | |
| induction of apoptosis via death domain receptors | |
| positive regulation of neuron apoptosis | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of transcription | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of chemokine biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription | |
| positive regulation of translational initiation by iron | |
| positive regulation of protein amino acid phosphorylation | |
| positive regulation of membrane protein ectodomain proteolysis | |
| positive regulation of hair follicle development | |
| positive regulation of interleukin-18 production | |
| positive regulation of chemokine production | |
| positive regulation of inflammatory response | |
| positive regulation of protein transport | |
| positive regulation of NF-kappaB import into nucleus | |
| positive regulation of cytokine secretion | |
| signal transduction | |
| regulation of cell proliferation | |
| regulation of insulin secretion | |
| activation of caspase activity | |
| regulation of osteoclast differentiation | |
| regulation of immunoglobulin secretion | |
| positive regulation of NF-kappaB transcription factor activity | |
| regulation of protein amino acid phosphorylation | |
| activation of MAPK activity | |
| tumor necrosis factor-mediated signaling pathway | |
| JNK cascade | |
| calcium-mediated signaling | |
| sequestering of triglyceride | |
| cell activation | |
| cell proliferation | |
| apoptosis | |
| transformed cell apoptosis | |
| leukocyte migration | |
| cellular extravasation | |
| osteoclast differentiation | |
| protein import into nucleus, translocation | |
| glucose metabolic process | |
| multicellular organismal development | |
| organ morphogenesis | |
| immune response | |
| humoral immune response | |
| chronic inflammatory response to antigenic stimulus | |
| receptor biosynthetic process | |
| response to virus | |
| defense response to bacterium | |
| response to mechanical stimulus | |
| response to salt stress | |
| response to glucocorticoid stimulus | |
| inflammatory response | |
| defense response |
| Hugo ID | 11892 |
|---|
| Human chromosome position | 6p21.3 |
|---|
| LocusLink ID | 7124 |
|---|---|
| 21926 | |
| 24835 |
| Alias | DIF |
|---|---|
| TNFA | |
| TNFSF2 | |
| TNF-alpha | |
| DADB-70P7.1 | |
| tumor necrosis factor alpha | |
| cachectin | |
| APC1 protein | |
| OTTHUMP00000029281 | |
| OTTHUMP00000037669 | |
| TNF, monocyte-derived | |
| TNF, macrophage-derived | |
| TNF superfamily, member 2 | |
| Tnfsf1a | |
| TNFalpha | |
| MGC151434 | |
| tumor necrosis factor | |
| TNF alpha | |
| tumor necrosis factor-alpha | |
| RATTNF | |
| MGC124630 | |
| tumor necrosis factor superfamily, member 2 | |
| tumor necrosis factor, alpha (cachetin) | |
| tumor necrosis factor superfamily member 2 | |
| tumor necrosis factor superfamily, member 2 | |
| tumor necrosis factor (TNF superfamily, member 2) | |
| tumor necrosis factor 2 | |
| tumor necrosis factor, alpha (cachectin) | |
| tumour necrosis factor alpha | |
| TNFA_HUMAN | |
| tumor necrosis factor II | |
| TNF superfamily, member II | |
| tumor necrotizing factor alpha | |
| APC1 gene | |
| TNF-a | |
| LOC257551 | |
| LOC257601 | |
| TNFSF2s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 191160 |
|---|---|
| 600807 | |
| 248310 | |
| 611162 | |
| 157300 |
| Swiss-Prot Accession | P01375 |
|---|---|
| Q5STB3 | |
| Q5RT83 | |
| Q9UBM5 | |
| P06804 | |
| Q3U593 | |
| Q0X0E6 | |
| Q3U4I6 | |
| Q6TDG3 | |
| P16599 |
| Unigene ID | Hs.241570 |
|---|---|
| Mm.1293 | |
| Rn.2275 |
| KEGG ID | mmu:21926 |
|---|---|
| rno:24835 |
| Swiss-Prot ID | TNFA_HUMAN |
|---|---|
| TNFA_MOUSE | |
| TNFA_RAT | |
| Q5STB3_HUMAN | |
| Q3U593_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005125 |
|---|---|
| 0042802 | |
| 0005164 | |
| 0000187 | |
| 0006919 | |
| 0006916 | |
| 0019722 | |
| 0001775 | |
| 0002439 | |
| 0042742 | |
| 0006006 | |
| 0006959 | |
| 0008625 | |
| 0006954 | |
| 0050901 | |
| 0007275 | |
| 0002037 | |
| 0008285 | |
| 0002740 | |
| 0046325 | |
| 0032715 | |
| 0050995 | |
| 0016481 | |
| 0000122 | |
| 0045071 | |
| 0009887 | |
| 0043123 | |
| 0046330 | |
| 0042346 | |
| 0051092 | |
| 0045080 | |
| 0032722 | |
| 0050715 | |
| 0043193 | |
| 0051798 | |
| 0034116 | |
| 0051044 | |
| 0045840 | |
| 0043525 | |
| 0045429 | |
| 0001934 | |
| 0051222 | |
| 0048661 | |
| 0050806 | |
| 0045941 | |
| 0045944 | |
| 0045994 | |
| 0000060 | |
| 0032800 | |
| 0051023 | |
| 0050796 | |
| 0045670 | |
| 0051384 | |
| 0009612 | |
| 0009651 | |
| 0009615 | |
| 0030730 | |
| 0007165 | |
| 0006927 | |
| 0033209 | |
| 0009897 | |
| 0005576 | |
| 0005615 | |
| 0005887 | |
| 0045121 | |
| 0001891 | |
| 0005886 | |
| 0055037 | |
| 0007254 | |
| 0008283 | |
| 0045123 | |
| 0006952 | |
| 0006955 | |
| 0006917 | |
| 0008624 | |
| 0050900 | |
| 0030316 | |
| 0008284 | |
| 0042127 | |
| 0001932 | |
| 0016021 | |
| 0016020 | |
| 0030141 | |
| 0006915 | |
| 0043065 | |
| 0050729 | |
| 0032741 |
| IPI ID | IPI00001671 |
|---|---|
| IPI00894294 | |
| IPI00128861 | |
| IPI00213948 |
| Mouse chromosome position | 17 19.06 cM |
|---|
| Homologene ID | 496 |
|---|
| MGI ID | 104798 |
|---|
| Rat chromosome position | 20p12 |
|---|
| RGD ID | 3876 |
|---|