| URN | urn:agi-llid:7412 |
|---|---|
| Connectivity | 798 |
| Name | VCAM1 |
| Description | vascular cell adhesion molecule 1 |
| Notes | This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq] |
| Pathway | PPARA Targets |
|---|---|
| PPARD Targets | |
| PPARG Targets | |
| RORA Targets | |
| PGR Targets |
| Ariadne Ontology | ECM-Cell adhesion proteins |
|---|
| GO Molecular Function | protein binding |
|---|---|
| cell adhesion molecule binding | |
| integrin binding |
| GO Cellular Component | membrane |
|---|---|
| apical part of cell | |
| filopodium | |
| microvillus | |
| external side of plasma membrane | |
| plasma membrane | |
| integral to membrane | |
| anchored to membrane | |
| extracellular space |
| GO Biological Process | cell adhesion |
|---|---|
| cell-cell adhesion | |
| leukocyte adhesion | |
| heterophilic cell adhesion | |
| leukocyte tethering or rolling | |
| positive regulation of T cell proliferation | |
| B cell differentiation | |
| membrane to membrane docking | |
| interspecies interaction between organisms |
| Group | ECM-Cell adhesion proteins |
|---|---|
| membrane | |
| apical part of cell | |
| filopodium | |
| microvillus | |
| external side of plasma membrane | |
| plasma membrane | |
| integral to membrane | |
| anchored to membrane | |
| extracellular space | |
| protein binding | |
| cell adhesion molecule binding | |
| integrin binding | |
| cell adhesion | |
| cell-cell adhesion | |
| leukocyte adhesion | |
| heterophilic cell adhesion | |
| leukocyte tethering or rolling | |
| positive regulation of T cell proliferation | |
| B cell differentiation | |
| membrane to membrane docking | |
| interspecies interaction between organisms |
| Hugo ID | 12663 |
|---|
| Human chromosome position | 1p32-p31 |
|---|
| LocusLink ID | 7412 |
|---|---|
| 22329 | |
| 25361 |
| Alias | CD106 |
|---|---|
| MGC99561 | |
| INCAM-100 | |
| DKFZp779G2333 | |
| vascular cell adhesion molecule 1 | |
| CD106 antigen | |
| OTTHUMP00000012650 | |
| OTTHUMP00000012651 | |
| Vcam-1 | |
| VCAM1B | |
| MGC108734 | |
| V-CAM 1 | |
| vascular cell adhesion molecule I | |
| V-CAM I | |
| Vcam1 | |
| Vcam I | |
| (sVCAM)-1 | |
| (sVCAM)-I | |
| (sVCAM)-1s | |
| V-CAM 1s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 192225 |
|---|
| Swiss-Prot Accession | A8K6R7 |
|---|---|
| P19320 | |
| Q53FL7 | |
| Q68DC4 | |
| Q3UPN1 | |
| P29533 | |
| Q3TR98 | |
| Q544V4 | |
| Q8K0X1 | |
| Q91X98 | |
| P29534 |
| Unigene ID | Hs.109225 |
|---|---|
| Mm.76649 | |
| Mm.440909 | |
| Rn.11267 |
| KEGG ID | hsa:7412 |
|---|---|
| mmu:22329 | |
| rno:25361 |
| Swiss-Prot ID | VCAM1_HUMAN |
|---|---|
| VCAM1_RAT | |
| A8K6R7_HUMAN | |
| Q3UPN1_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0050839 |
|---|---|
| 0005178 | |
| 0030183 | |
| 0007157 | |
| 0044419 | |
| 0050901 | |
| 0022614 | |
| 0042102 | |
| 0045177 | |
| 0009897 | |
| 0005615 | |
| 0030175 | |
| 0016021 | |
| 0016020 | |
| 0005902 | |
| 0005515 | |
| 0007155 | |
| 0016337 | |
| 0007159 | |
| 0031225 | |
| 0005886 |
| IPI ID | IPI00018136 |
|---|---|
| IPI00082827 | |
| IPI00643490 | |
| IPI00643090 | |
| IPI00126834 | |
| IPI00264750 | |
| IPI00653571 | |
| IPI00205631 | |
| IPI00780065 |
| Mouse chromosome position | 3 50.8 cM |
|---|
| Homologene ID | 838 |
|---|
| MGI ID | 98926 |
|---|
| Rat chromosome position | 2q41 |
|---|
| RGD ID | 3952 |
|---|