| URN | urn:agi-llid:1839 |
|---|---|
| Connectivity | 461 |
| Name | HBEGF |
| Description | heparin-binding EGF-like growth factor |
| Notes | activates epidermal growth factor receptor mediated signaling; contributes to neuronal survival; may play a role in neurogenesis during ventral midbrain development [RGD] |
| Pathway | EGFR -> CTNND signaling |
|---|---|
| EGFR -> SMAD1 signaling | |
| EGFR/ERBB -> STAT signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB2 -> CTNNB signaling | |
| ERBB2/3 -> EP300/ETS/ETV/SP1 signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| EGFR -> ZNF259 signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| PPARG Targets |
| Ariadne Ontology | GF |
|---|
| GO Molecular Function | heparin binding |
|---|---|
| growth factor activity | |
| epidermal growth factor receptor binding | |
| receptor activity |
| GO Cellular Component | extracellular region |
|---|---|
| cell surface | |
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| extracellular space |
| GO Biological Process | angiogenesis |
|---|---|
| negative regulation of elastin biosynthetic process | |
| positive regulation of cell growth | |
| positive regulation of keratinocyte migration | |
| positive regulation of smooth muscle cell proliferation | |
| signal transduction | |
| epidermal growth factor receptor signaling pathway | |
| regulation of heart contraction | |
| wound healing, spreading of epidermal cells | |
| blastocyst growth | |
| muscle organ development | |
| nervous system development |
| Group | GF |
|---|---|
| extracellular region | |
| cell surface | |
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| extracellular space | |
| heparin binding | |
| growth factor activity | |
| epidermal growth factor receptor binding | |
| receptor activity | |
| angiogenesis | |
| negative regulation of elastin biosynthetic process | |
| positive regulation of cell growth | |
| positive regulation of keratinocyte migration | |
| positive regulation of smooth muscle cell proliferation | |
| signal transduction | |
| epidermal growth factor receptor signaling pathway | |
| regulation of heart contraction | |
| wound healing, spreading of epidermal cells | |
| blastocyst growth | |
| muscle organ development | |
| nervous system development |
| Hugo ID | 3059 |
|---|
| Human chromosome position | 5q23 |
|---|
| LocusLink ID | 1839 |
|---|---|
| 15200 | |
| 25433 |
| Alias | DTR |
|---|---|
| DTS | |
| DTSF | |
| HEGFL | |
| heparin-binding EGF-like growth factor | |
| heparin-binding epidermal growth factor | |
| diphtheria toxin receptor (heparin-binding EGF-like growth factor) | |
| diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) | |
| HB-EGF | |
| AW047313 | |
| MGC107656 | |
| diphtheria toxin receptor | |
| heparin binding epidermal growth factor-like growth factor | |
| GFHB | |
| heparin-binding epidermal -growth factor | |
| heparin-binding epidermal -growth - like growth factor | |
| Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor) | |
| Diphteria toxin receptors | |
| diphtheria toxin receptors | |
| proHB-EGF | |
| Diphteria toxin receptor | |
| HBEGF | |
| HBGF_HUMAN | |
| LOC225370 | |
| heparin-binding epidermal growth factor-like growth factor | |
| heparin-binding epidermal growth-like growth factor |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 126150 |
|---|
| Swiss-Prot Accession | B2R821 |
|---|---|
| Q99075 | |
| Q14487 | |
| Q53H93 | |
| Q9UMJ6 | |
| Q06186 | |
| Q5FW64 | |
| Q06175 |
| Unigene ID | Hs.799 |
|---|---|
| Hs.592942 | |
| Mm.289681 | |
| Rn.10148 |
| KEGG ID | hsa:1839 |
|---|---|
| mmu:15200 | |
| rno:25433 |
| Swiss-Prot ID | HBEGF_HUMAN |
|---|---|
| HBEGF_MOUSE | |
| HBEGF_RAT | |
| B2R821_HUMAN | |
| Q5FW64_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005154 |
|---|---|
| 0008083 | |
| 0008201 | |
| 0004872 | |
| 0007173 | |
| 0007517 | |
| 0051549 | |
| 0048661 | |
| 0008016 | |
| 0007165 | |
| 0035313 | |
| 0009986 | |
| 0005576 | |
| 0005615 | |
| 0005887 | |
| 0005886 | |
| 0001525 | |
| 0001832 | |
| 0016021 | |
| 0016020 | |
| 0051545 | |
| 0007399 | |
| 0030307 |
| IPI ID | IPI00012948 |
|---|---|
| IPI00111772 | |
| IPI00190601 | |
| IPI00778070 |
| Mouse chromosome position | 18 15.0 cM |
|---|
| Homologene ID | 1466 |
|---|
| MGI ID | 96070 |
|---|
| Rat chromosome position | 18p11 |
|---|
| RGD ID | 2526 |
|---|