| URN | urn:agi-llid:1906 |
|---|---|
| Connectivity | 1691 |
| Name | EDN1 |
| Description | endothelin 1 |
| Notes | activates ERK1/2 mediated signaling; may play a role in regulation of cardiac contractile force [RGD] |
| Pathway | EndothelinRb -> AP-1/CREB/ELK-SRF signaling |
|---|---|
| EndothelinRa -> AP-1/CREB signaling | |
| Common Regulators | |
| RARA Targets | |
| PPARA Targets | |
| PPARG Targets | |
| FXR Targets | |
| ERA Pathway | |
| Common Regulators and Small Molecules |
| Ariadne Ontology | Neuromodulator |
|---|
| GO Molecular Function | protein binding |
|---|---|
| receptor binding | |
| hormone activity | |
| endothelin A receptor binding | |
| endothelin B receptor binding |
| GO Cellular Component | extracellular region |
|---|---|
| cytoplasm | |
| extracellular space |
| GO Biological Process | patterning of blood vessels |
|---|---|
| positive regulation of sarcomere organization | |
| negative regulation of hormone secretion | |
| negative regulation of cAMP biosynthetic process | |
| negative regulation of nitric-oxide synthase biosynthetic process | |
| negative regulation of blood coagulation | |
| positive regulation of cell proliferation | |
| positive regulation of hormone secretion | |
| positive regulation of mitosis | |
| positive regulation of endothelial cell migration | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of heart rate | |
| positive regulation of cardiac muscle hypertrophy | |
| positive regulation of smooth muscle contraction | |
| protein kinase C deactivation | |
| positive regulation of JUN kinase activity | |
| rhythmic excitation | |
| activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway | |
| elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) | |
| protein kinase cascade | |
| phosphoinositide 3-kinase cascade | |
| calcium-mediated signaling | |
| inositol phosphate-mediated signaling | |
| regulation of vasoconstriction | |
| regulation of blood pressure | |
| membrane depolarization | |
| natriuresis | |
| regulation of pH | |
| diuresis | |
| regulation of systemic arterial blood pressure by endothelin | |
| body fluid secretion | |
| positive regulation of cell size | |
| peptide hormone secretion | |
| regulation of blood vessel size | |
| vasoconstriction | |
| artery smooth muscle contraction | |
| vein smooth muscle contraction | |
| leukocyte activation | |
| cell-cell signaling | |
| neutrophil chemotaxis | |
| neural crest cell development | |
| middle ear morphogenesis | |
| blood vessel morphogenesis | |
| heart development | |
| cartilage development | |
| skeletal system development | |
| in utero embryonic development | |
| dorsal-ventral pattern formation | |
| nitric oxide transport | |
| glucose transport | |
| respiratory gaseous exchange | |
| response to hypoxia |
| Group | Neuromodulator |
|---|---|
| extracellular region | |
| cytoplasm | |
| extracellular space | |
| protein binding | |
| receptor binding | |
| hormone activity | |
| endothelin A receptor binding | |
| endothelin B receptor binding | |
| patterning of blood vessels | |
| positive regulation of sarcomere organization | |
| negative regulation of hormone secretion | |
| negative regulation of cAMP biosynthetic process | |
| negative regulation of nitric-oxide synthase biosynthetic process | |
| negative regulation of blood coagulation | |
| positive regulation of cell proliferation | |
| positive regulation of hormone secretion | |
| positive regulation of mitosis | |
| positive regulation of endothelial cell migration | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of heart rate | |
| positive regulation of cardiac muscle hypertrophy | |
| positive regulation of smooth muscle contraction | |
| protein kinase C deactivation | |
| positive regulation of JUN kinase activity | |
| rhythmic excitation | |
| activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway | |
| elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) | |
| protein kinase cascade | |
| phosphoinositide 3-kinase cascade | |
| calcium-mediated signaling | |
| inositol phosphate-mediated signaling | |
| regulation of vasoconstriction | |
| regulation of blood pressure | |
| membrane depolarization | |
| natriuresis | |
| regulation of pH | |
| diuresis | |
| regulation of systemic arterial blood pressure by endothelin | |
| body fluid secretion | |
| positive regulation of cell size | |
| peptide hormone secretion | |
| regulation of blood vessel size | |
| vasoconstriction | |
| artery smooth muscle contraction | |
| vein smooth muscle contraction | |
| leukocyte activation | |
| cell-cell signaling | |
| neutrophil chemotaxis | |
| neural crest cell development | |
| middle ear morphogenesis | |
| blood vessel morphogenesis | |
| heart development | |
| cartilage development | |
| skeletal system development | |
| in utero embryonic development | |
| dorsal-ventral pattern formation | |
| nitric oxide transport | |
| glucose transport | |
| respiratory gaseous exchange | |
| response to hypoxia |
| Hugo ID | 3176 |
|---|
| Human chromosome position | 6p24.1 |
|---|
| LocusLink ID | 1906 |
|---|---|
| 13614 | |
| 24323 |
| Alias | ET1 |
|---|---|
| HDLCQ7 | |
| endothelin 1 | |
| OTTHUMP00000016038 | |
| OTTHUMP00000039245 | |
| ET-1 | |
| preproET | |
| preproendothelin | |
| endothelin I | |
| EDN I | |
| EDN1 | |
| ET I | |
| ET I protein | |
| ET-1 gene | |
| ET-1 mRNA | |
| ET-1 protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 131240 |
|---|
| Swiss-Prot Accession | P05305 |
|---|---|
| Q6FH53 | |
| P22387 | |
| Q544E0 | |
| P22388 | |
| Q9JLX8 |
| Unigene ID | Hs.511899 |
|---|---|
| Hs.713645 | |
| Mm.14543 | |
| Rn.10918 |
| KEGG ID | mmu:13614 |
|---|---|
| rno:24323 |
| Swiss-Prot ID | EDN1_HUMAN |
|---|---|
| EDN1_MOUSE | |
| EDN1_RAT | |
| Q6FH53_HUMAN | |
| Q544E0_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0031707 |
|---|---|
| 0031708 | |
| 0005179 | |
| 0031583 | |
| 0007205 | |
| 0014824 | |
| 0048514 | |
| 0019722 | |
| 0051216 | |
| 0007267 | |
| 0030146 | |
| 0009953 | |
| 0051482 | |
| 0015758 | |
| 0007507 | |
| 0001701 | |
| 0048016 | |
| 0045321 | |
| 0051899 | |
| 0042474 | |
| 0030147 | |
| 0030195 | |
| 0030818 | |
| 0046888 | |
| 0051771 | |
| 0014032 | |
| 0030593 | |
| 0030185 | |
| 0001569 | |
| 0030072 | |
| 0014065 | |
| 0043507 | |
| 0010613 | |
| 0045793 | |
| 0010595 | |
| 0010460 | |
| 0046887 | |
| 0045840 | |
| 0045429 | |
| 0060298 | |
| 0048661 | |
| 0045987 | |
| 0042313 | |
| 0008217 | |
| 0006885 | |
| 0003100 | |
| 0019229 | |
| 0007585 | |
| 0001666 | |
| 0043179 | |
| 0014826 | |
| 0005737 | |
| 0005576 | |
| 0005615 | |
| 0005515 | |
| 0005102 | |
| 0007186 | |
| 0007589 | |
| 0008284 | |
| 0050880 | |
| 0001501 | |
| 0042310 | |
| 0007243 |
| IPI ID | IPI00008327 |
|---|---|
| IPI00743618 | |
| IPI00127462 | |
| IPI00206210 |
| Mouse chromosome position | 13 26.0 cM |
|---|
| Homologene ID | 1476 |
|---|
| MGI ID | 95283 |
|---|
| Rat chromosome position | 17p12 |
|---|
| RGD ID | 2532 |
|---|