| URN | urn:agi-llid:1956 |
|---|---|
| Connectivity | 1959 |
| Name | EGFR |
| Description | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) |
| Notes | The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq] |
| Pathway | ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling |
|---|---|
| ThrombinR -> NF-kB signaling | |
| CholinergicRm -> CREB/ELK-SRF signaling | |
| DopamineR2 -> NF-kB signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| EDG2 -> ELK-SRF signaling | |
| GRM1/5 -> CREB signaling | |
| VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| NeurotensinR -> ELK-SRF/AP-1/EGR signaling | |
| VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| EGFR -> CTNND signaling | |
| EGFR -> SMAD1 signaling | |
| EGFR/ERBB -> STAT signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB2 -> CTNNB signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| EGFR -> ZNF259 signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| Common Regulators | |
| RARA Targets | |
| RARG Targets | |
| PPARG Targets | |
| LXRA Targets | |
| VDR Targets | |
| ERA Pathway | |
| ERB Targets | |
| MR Target Genes | |
| PGR Targets | |
| Common Regulators and Small Molecules |
| Ariadne Ontology | Oncogenes |
|---|---|
| GFR |
| GO Molecular Function | protein binding |
|---|---|
| nucleotide binding | |
| double-stranded DNA binding | |
| ATP binding | |
| identical protein binding | |
| actin filament binding | |
| protein phosphatase binding | |
| protein heterodimerization activity | |
| transferase activity | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| MAP-ERK kinase kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| epidermal growth factor receptor activity | |
| nitric-oxide synthase regulator activity | |
| signal transducer activity | |
| receptor activity | |
| transmembrane receptor activity |
| GO Cellular Component | extracellular region |
|---|---|
| intracellular | |
| membrane | |
| apical plasma membrane | |
| AP-2 adaptor complex | |
| cytoplasm | |
| endosome | |
| endoplasmic reticulum | |
| endocytic vesicle | |
| nucleus | |
| plasma membrane | |
| integral to membrane | |
| Shc-EGFR complex | |
| basolateral plasma membrane | |
| extracellular space |
| GO Biological Process | cell-cell adhesion |
|---|---|
| negative regulation of cell cycle | |
| negative regulation of mitotic cell cycle | |
| negative regulation of apoptosis | |
| positive regulation of cell proliferation | |
| positive regulation of synaptic transmission, glutamatergic | |
| positive regulation of cyclin-dependent protein kinase activity during G1-S | |
| positive regulation of cell migration | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of phosphorylation | |
| signal transduction | |
| regulation of cell proliferation | |
| regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of MAP kinase activity | |
| activation of MAPKK activity | |
| cell surface receptor linked signal transduction | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| protein kinase cascade | |
| activation of phospholipase A2 activity by calcium-mediated signaling | |
| activation of phospholipase C activity | |
| regulation of nitric-oxide synthase activity | |
| astrocyte activation | |
| neuron projection morphogenesis | |
| cell morphogenesis | |
| protein insertion into membrane | |
| translation | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| ossification | |
| salivary gland morphogenesis | |
| tongue development | |
| ovulation cycle | |
| response to stress | |
| response to osmotic stress | |
| response to UV-A | |
| response to oxidative stress | |
| response to calcium ion | |
| response to lipid | |
| circadian rhythm |
| Group | Oncogenes |
|---|---|
| GFR | |
| extracellular region | |
| intracellular | |
| membrane | |
| apical plasma membrane | |
| AP-2 adaptor complex | |
| cytoplasm | |
| endosome | |
| endoplasmic reticulum | |
| endocytic vesicle | |
| nucleus | |
| plasma membrane | |
| integral to membrane | |
| Shc-EGFR complex | |
| basolateral plasma membrane | |
| extracellular space | |
| protein binding | |
| nucleotide binding | |
| double-stranded DNA binding | |
| ATP binding | |
| identical protein binding | |
| actin filament binding | |
| protein phosphatase binding | |
| protein heterodimerization activity | |
| transferase activity | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| MAP-ERK kinase kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| epidermal growth factor receptor activity | |
| nitric-oxide synthase regulator activity | |
| signal transducer activity | |
| receptor activity | |
| transmembrane receptor activity | |
| cell-cell adhesion | |
| negative regulation of cell cycle | |
| negative regulation of mitotic cell cycle | |
| negative regulation of apoptosis | |
| positive regulation of cell proliferation | |
| positive regulation of synaptic transmission, glutamatergic | |
| positive regulation of cyclin-dependent protein kinase activity during G1-S | |
| positive regulation of cell migration | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of phosphorylation | |
| signal transduction | |
| regulation of cell proliferation | |
| regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of MAP kinase activity | |
| activation of MAPKK activity | |
| cell surface receptor linked signal transduction | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| protein kinase cascade | |
| activation of phospholipase A2 activity by calcium-mediated signaling | |
| activation of phospholipase C activity | |
| regulation of nitric-oxide synthase activity | |
| astrocyte activation | |
| neuron projection morphogenesis | |
| cell morphogenesis | |
| protein insertion into membrane | |
| translation | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| ossification | |
| salivary gland morphogenesis | |
| tongue development | |
| ovulation cycle | |
| response to stress | |
| response to osmotic stress | |
| response to UV-A | |
| response to oxidative stress | |
| response to calcium ion | |
| response to lipid | |
| circadian rhythm |
| Hugo ID | 3236 |
|---|
| Human chromosome position | 7p12 |
|---|
| LocusLink ID | 1956 |
|---|---|
| 13649 | |
| 24329 |
| Alias | ERBB |
|---|---|
| HER1 | |
| mENA | |
| ERBB1 | |
| PIG61 | |
| epidermal growth factor receptor | |
| cell growth inhibiting protein 40 | |
| cell proliferation-inducing protein 61 | |
| avian erythroblastic leukemia viral (v-erb-b) oncogene homolog | |
| Wa5 | |
| wa2 | |
| Errp | |
| wa-2 | |
| AI552599 | |
| 9030024J15Rik | |
| RP23-295E4.1 | |
| waved 2 | |
| OTTMUSP00000005385 | |
| OTTMUSP00000005386 | |
| ErbB-1 | |
| EGFR-related peptide | |
| avian erythroblastic leukemia viral (v-erbB) oncogene homolog | |
| Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1) | |
| epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1) | |
| EGFR_HUMAN | |
| EGFR_MOUSE | |
| ERB1 | |
| GNB:6478868 | |
| v-erb-b | |
| v-erbB oncogene homolog | |
| EGFR | |
| EGF receptors | |
| v-erb-bs | |
| epidermal growth factor receptors | |
| EGF receptor | |
| erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian | |
| epidermal growth factor receptor (avian erythroblastic leukemia viral (v-er | |
| receptor for epidermal growth factor | |
| waved II | |
| EGF-R | |
| erythroblastic leukemia viral (v-erb-b) oncogene homolog | |
| ERBB I | |
| wa II | |
| RIKEN cDNA 9030024J15 gene | |
| truncated epidermal growth factor receptor | |
| Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog | |
| LOC360274 | |
| epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | |
| EGF-Rs | |
| EGFRs | |
| waved 2s | |
| EGF-EGFR | |
| (EGF-EGFR) DIMER COMPLEX | |
| (EGF-EGFR) DIMER P-TYR1068 | |
| (EGF-EGFR) DIMER-ATP | |
| EGF R |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 131550 |
|---|---|
| 211980 |
| Swiss-Prot Accession | P00533 |
|---|---|
| Q147T7 | |
| Q2TTR7 | |
| Q504U8 | |
| Q59FL8 | |
| Q68GS6 | |
| Q75MF2 | |
| Q8WZA5 | |
| Q9H3C8 | |
| Q9WVF5 | |
| Q01279 | |
| Q5SVE8 | |
| Q3TQS6 | |
| Q5SVE7 | |
| Q8VHI0 | |
| Q99PK1 | |
| Q9EP98 | |
| Q9EQR1 | |
| Q9ERV6 | |
| Q9QX70 | |
| Q62954 | |
| Q9ESE0 | |
| Q9JLR6 | |
| Q9WTS1 |
| Unigene ID | Hs.488293 |
|---|---|
| Mm.8534 | |
| Mm.420648 | |
| Mm.439882 | |
| Rn.37227 |
| KEGG ID | mmu:13649 |
|---|---|
| rno:24329 |
| EC Number | 2.7.10.1 |
|---|
| Swiss-Prot ID | EGFR_HUMAN |
|---|---|
| EGFR_MOUSE | |
| Q5SVE8_MOUSE | |
| Q9QX70_RAT | |
| Q9WVF5_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0005524 |
|---|---|
| 0004710 | |
| 0051015 | |
| 0003690 | |
| 0005006 | |
| 0042802 | |
| 0030235 | |
| 0000166 | |
| 0046982 | |
| 0019903 | |
| 0016740 | |
| 0004888 | |
| 0043006 | |
| 0007202 | |
| 0007166 | |
| 0016337 | |
| 0007173 | |
| 0045786 | |
| 0001503 | |
| 0043406 | |
| 0030335 | |
| 0031659 | |
| 0050679 | |
| 0045429 | |
| 0042327 | |
| 0046777 | |
| 0051205 | |
| 0050999 | |
| 0050730 | |
| 0070141 | |
| 0006950 | |
| 0030122 | |
| 0016323 | |
| 0005737 | |
| 0030139 | |
| 0005783 | |
| 0005768 | |
| 0005576 | |
| 0005615 | |
| 0016021 | |
| 0005622 | |
| 0005634 | |
| 0005886 | |
| 0016301 | |
| 0005515 | |
| 0004672 | |
| 0004713 | |
| 0004872 | |
| 0004871 | |
| 0004714 | |
| 0000902 | |
| 0008284 | |
| 0006468 | |
| 0042127 | |
| 0007435 | |
| 0007165 | |
| 0007169 | |
| 0016020 | |
| 0000186 | |
| 0048143 | |
| 0007623 | |
| 0043066 | |
| 0045930 | |
| 0048812 | |
| 0042698 | |
| 0048661 | |
| 0051968 | |
| 0007243 | |
| 0051592 | |
| 0033993 | |
| 0006970 | |
| 0006979 | |
| 0043586 | |
| 0006412 | |
| 0070435 | |
| 0016324 |
| IPI ID | IPI00018274 |
|---|---|
| IPI00221346 | |
| IPI00221347 | |
| IPI00221348 | |
| IPI00121190 | |
| IPI00474965 | |
| IPI00411099 | |
| IPI00191874 | |
| IPI00212694 | |
| IPI00777623 |
| Mouse chromosome position | 11 9.0 cM |
|---|
| Homologene ID | 74545 |
|---|
| MGI ID | 95294 |
|---|
| Rat chromosome position | 14q22 |
|---|
| RGD ID | 2543 |
|---|