| URN | urn:agi-llid:6198 |
|---|---|
| Connectivity | 665 |
| Name | RPS6KB1 |
| Description | ribosomal protein S6 kinase, 70kDa, polypeptide 1 |
| Notes | This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. [provided by RefSeq] |
| Pathway | PPARG Targets |
|---|
| Ariadne Ontology | p70S6K |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| peptide binding | |
| ATP binding | |
| transferase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| ribosomal protein S6 kinase activity |
| GO Cellular Component | synapse |
|---|---|
| cell surface | |
| soluble fraction | |
| synaptosome | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytosol | |
| nucleus | |
| cell junction |
| GO Biological Process | positive regulation of smooth muscle cell migration |
|---|---|
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of skeletal muscle growth | |
| signal transduction | |
| cell migration | |
| protein amino acid phosphorylation | |
| cellular response to hormone stimulus | |
| aging | |
| response to lipopolysaccharide | |
| skeletal muscle contraction | |
| skeletal muscle atrophy | |
| response to electrical stimulus involved in regulation of muscle adaptation | |
| long-term memory | |
| response to mechanical stimulus | |
| response to heat | |
| response to drug | |
| response to organic substance | |
| response to toxin | |
| response to nutrient | |
| response to amino acid stimulus | |
| response to leucine | |
| response to peptide hormone stimulus | |
| response to glucagon stimulus | |
| response to insulin stimulus | |
| response to testosterone stimulus | |
| response to glucocorticoid stimulus | |
| response to ethanol | |
| response to organic nitrogen | |
| response to organic cyclic substance | |
| response to glucose stimulus | |
| response to wounding |
| Group | p70S6K |
|---|---|
| synapse | |
| cell surface | |
| soluble fraction | |
| synaptosome | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytosol | |
| nucleus | |
| cell junction | |
| nucleotide binding | |
| peptide binding | |
| ATP binding | |
| transferase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| ribosomal protein S6 kinase activity | |
| positive regulation of smooth muscle cell migration | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of skeletal muscle growth | |
| signal transduction | |
| cell migration | |
| protein amino acid phosphorylation | |
| cellular response to hormone stimulus | |
| aging | |
| response to lipopolysaccharide | |
| skeletal muscle contraction | |
| skeletal muscle atrophy | |
| response to electrical stimulus involved in regulation of muscle adaptation | |
| long-term memory | |
| response to mechanical stimulus | |
| response to heat | |
| response to drug | |
| response to organic substance | |
| response to toxin | |
| response to nutrient | |
| response to amino acid stimulus | |
| response to leucine | |
| response to peptide hormone stimulus | |
| response to glucagon stimulus | |
| response to insulin stimulus | |
| response to testosterone stimulus | |
| response to glucocorticoid stimulus | |
| response to ethanol | |
| response to organic nitrogen | |
| response to organic cyclic substance | |
| response to glucose stimulus | |
| response to wounding |
| Hugo ID | 10436 |
|---|
| Human chromosome position | 17q23.1 |
|---|
| LocusLink ID | 6198 |
|---|---|
| 83840 |
| Alias | S6K |
|---|---|
| PS6K | |
| S6K1 | |
| STK14A | |
| p70-S6K | |
| p70-alpha | |
| p70(S6K)-alpha | |
| ribosomal protein S6 kinase, 70kDa, polypeptide 1 | |
| p70 S6 kinase, alpha 1 | |
| p70 S6 kinase, alpha 2 | |
| serine/threonine kinase 14 alpha | |
| ribosomal protein S6 kinase, 70kD, polypeptide 1 | |
| S6 kinase | |
| ribosomal protein S6 kinase, polypeptide 1 | |
| p70/85s6k | |
| RIKEN cDNA 2610318I15 gene | |
| 70 kDa ribosomal protein S6 kinase, , polypeptide 1 | |
| 70 kDa ribosomal protein S6 kinase, , polypeptide I | |
| ribosomal S6 kinase, 70kD, polypeptide | |
| ribosomal S6 kinase, 70kDa, polypeptide | |
| serine/threonine kinase 14 | |
| ribosomal protein S6 kinase, 70kD, polypeptide I | |
| ribosomal protein S6 kinase, 70kDa, polypeptide I | |
| Rps6kb1 | |
| Rps6kb I | |
| S6K I | |
| p70 S6 kinase | |
| 2610318I15Rik | |
| p70 s6k, p85 s6k |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus |
| OMIM ID | 608938 |
|---|
| Swiss-Prot Accession | P23443 |
|---|---|
| Q4G0X7 | |
| Q7Z721 | |
| P67999 |
| Unigene ID | Hs.463642 |
|---|---|
| Rn.4042 |
| KEGG ID | hsa:6198 |
|---|
| EC Number | 2.7.11.1 |
|---|
| Swiss-Prot ID | KS6B1_HUMAN |
|---|---|
| KS6B1_RAT |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0005524 |
|---|---|
| 0000166 | |
| 0004674 | |
| 0016740 | |
| 0006468 | |
| 0007165 | |
| 0030054 | |
| 0005737 | |
| 0005829 | |
| 0045202 | |
| 0019717 | |
| 0042277 | |
| 0004672 | |
| 0004711 | |
| 0007568 | |
| 0016477 | |
| 0032870 | |
| 0007616 | |
| 0048633 | |
| 0014911 | |
| 0048661 | |
| 0043200 | |
| 0042493 | |
| 0014878 | |
| 0045471 | |
| 0033762 | |
| 0051384 | |
| 0009749 | |
| 0009408 | |
| 0032868 | |
| 0043201 | |
| 0032496 | |
| 0009612 | |
| 0007584 | |
| 0014070 | |
| 0010243 | |
| 0010033 | |
| 0043434 | |
| 0033574 | |
| 0009636 | |
| 0009611 | |
| 0014732 | |
| 0003009 | |
| 0009986 | |
| 0005634 | |
| 0048471 | |
| 0005625 |
| IPI ID | IPI00216132 |
|---|---|
| IPI00759649 | |
| IPI00647496 | |
| IPI00795216 | |
| IPI00471630 | |
| IPI00760127 | |
| IPI00392901 |
| Homologene ID | 81703 |
|---|
| Rat chromosome position | 10q26 |
|---|
| RGD ID | 620683 |
|---|