Protein FAS

URN	urn:agi-llid:355
Connectivity	1530
Name	FAS
Description	Fas (TNF receptor superfamily, member 6)
Notes	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq]

Ariadne Ontology	TNFR

GO Molecular Function	protein binding
	identical protein binding
	tumor necrosis factor receptor activity
	receptor activity
	transmembrane receptor activity

GO Cellular Component	extracellular region
	cell surface
	membrane
	soluble fraction
	external side of plasma membrane
	perinuclear region of cytoplasm
	cytosol
	plasma membrane
	membrane raft
	integral to membrane
	caveola

GO Biological Process	protein complex assembly
	protein homooligomerization
	negative regulation of B cell activation
	negative regulation of apoptosis
	anti-apoptosis
	positive regulation of apoptosis
	induction of apoptosis
	induction of apoptosis by extracellular signals
	induction of apoptosis via death domain receptors
	activation of pro-apoptotic gene products
	signal transduction
	regulation of lymphocyte differentiation
	regulation of myeloid cell differentiation
	T cell homeostasis
	activation-induced cell death of T cells
	negative thymic T cell selection
	apoptosis
	transformed cell apoptosis
	inflammatory cell apoptosis
	aging
	spleen development
	immune response
	B cell mediated immunity
	immunoglobulin production
	gene expression
	response to lipopolysaccharide
	ovulation cycle
	renal system process
	spermatogenesis
	response to drug
	response to inorganic substance
	response to protein stimulus
	response to toxin
	response to cytokine stimulus
	response to peptide hormone stimulus
	response to estrogen stimulus
	response to glucocorticoid stimulus
	response to hypoxia

Group	TNFR
	extracellular region
	cell surface
	membrane
	soluble fraction
	external side of plasma membrane
	perinuclear region of cytoplasm
	cytosol
	plasma membrane
	membrane raft
	integral to membrane
	caveola
	protein binding
	identical protein binding
	tumor necrosis factor receptor activity
	receptor activity
	transmembrane receptor activity
	protein complex assembly
	protein homooligomerization
	negative regulation of B cell activation
	negative regulation of apoptosis
	anti-apoptosis
	positive regulation of apoptosis
	induction of apoptosis
	induction of apoptosis by extracellular signals
	induction of apoptosis via death domain receptors
	activation of pro-apoptotic gene products
	signal transduction
	regulation of lymphocyte differentiation
	regulation of myeloid cell differentiation
	T cell homeostasis
	activation-induced cell death of T cells
	negative thymic T cell selection
	apoptosis
	transformed cell apoptosis
	inflammatory cell apoptosis
	aging
	spleen development
	immune response
	B cell mediated immunity
	immunoglobulin production
	gene expression
	response to lipopolysaccharide
	ovulation cycle
	renal system process
	spermatogenesis
	response to drug
	response to inorganic substance
	response to protein stimulus
	response to toxin
	response to cytokine stimulus
	response to peptide hormone stimulus
	response to estrogen stimulus
	response to glucocorticoid stimulus
	response to hypoxia

Hugo ID	11920

Human chromosome position	10q24.1

Alias	APT1
	CD95
	FAS1
	APO-1
	FASTM
	ALPS1A
	TNFRSF6
	tumor necrosis factor receptor superfamily, member 6
	Fas AMA
	Fas antigen
	CD95 antigen
	OTTHUMP00000020045
	OTTHUMP00000020046
	OTTHUMP00000020051
	OTTHUMP00000059646
	apoptosis antigen 1
	APO-1 cell surface antigen
	tumor necrosis factor receptor superfamily member 6
	lpr
	TNFR6
	AI196731
	Fas (TNF receptor superfamily member)
	lymphoproliferation
	Fas
	Fas receptor
	apo-1 antigen
	Fas antigen (ATP1)
	apoptosis-mediating surface antigen FAS
	apoptosis (APO-1) antigen 1
	TNR6
	TNR6_HUMAN
	apoptosis (APO-1) antigen I
	apoptosis antigen I
	FASL receptor
	Tumor necrosis factor receptor superfamily member 6 precursor
	APT I
	APO I
	sFas
	APO-1/FAS
	FasR
	LOC365454
	Fas receptors
	FASL receptors
	FAS I
	lymphoproliferation protein
	tumor necrosis factor receptor 6
	Fas (TNF receptor superfamily member 6)
	LOC368136
	lymphoproliferation gene

OMIM ID	134637
	601859

KEGG ID	hsa:355
	rno:246097

Cell Localization	Plasma membrane

Mouse chromosome position	19 23.0 cM

Homologene ID	27

MGI ID	95484

Rat chromosome position	1q52

RGD ID	619831