| URN | urn:agi-llid:959 |
|---|---|
| Connectivity | 781 |
| Name | CD40LG |
| Description | CD40 ligand |
| Notes | The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq] |
| Pathway | TNFRSF5/13B -> NFATC1 signaling |
|---|---|
| TNFRSF5 -> STAT signaling | |
| TNFR -> NF-kB signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFRSF5/6 -> RB1/E2F signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| Common Regulators | |
| PPARG Targets | |
| ERA Pathway | |
| GR Targets |
| Ariadne Ontology | TNF family |
|---|
| GO Molecular Function | molecular_function |
|---|---|
| cytokine activity | |
| tumor necrosis factor receptor binding | |
| CD40 receptor binding |
| GO Cellular Component | cellular_component |
|---|---|
| extracellular region | |
| membrane | |
| soluble fraction | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| extracellular space |
| GO Biological Process | biological_process |
|---|---|
| leukocyte adhesion | |
| anti-apoptosis | |
| positive regulation of interleukin-12 production | |
| signal transduction | |
| regulation of immunoglobulin secretion | |
| platelet activation | |
| isotype switching | |
| B cell differentiation | |
| B cell proliferation | |
| immunoglobulin secretion | |
| immune response | |
| inflammatory response |
| Group | TNF family |
|---|---|
| cellular_component | |
| extracellular region | |
| membrane | |
| soluble fraction | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| extracellular space | |
| molecular_function | |
| cytokine activity | |
| tumor necrosis factor receptor binding | |
| CD40 receptor binding | |
| biological_process | |
| leukocyte adhesion | |
| anti-apoptosis | |
| positive regulation of interleukin-12 production | |
| signal transduction | |
| regulation of immunoglobulin secretion | |
| platelet activation | |
| isotype switching | |
| B cell differentiation | |
| B cell proliferation | |
| immunoglobulin secretion | |
| immune response | |
| inflammatory response |
| Hugo ID | 11935 |
|---|
| Human chromosome position | Xq26 |
|---|
| LocusLink ID | 959 |
|---|---|
| 21947 | |
| 84349 |
| Alias | IGM |
|---|---|
| IMD3 | |
| TRAP | |
| gp39 | |
| CD154 | |
| CD40L | |
| HIGM1 | |
| T-BAM | |
| TNFSF5 | |
| hCD40L | |
| RP3-527F8.3 | |
| CD40 ligand | |
| OTTHUMP00000024130 | |
| CD40 antigen ligand | |
| T-B cell-activating molecule | |
| TNF-related activation protein | |
| tumor necrosis factor (ligand) superfamily member 5 | |
| Ly62 | |
| Ly-62 | |
| RP23-153G22.3 | |
| OTTMUSP00000019349 | |
| tumor necrosis factor (ligand) superfamily, member 5 | |
| CD40 ligand CD154 | |
| IGM antigene | |
| TNF-related activating protein | |
| CD40 antigen ligand (hyper-IgM syndrome) | |
| CD40LG | |
| T cell antigen GP39 | |
| TNF5 | |
| TNF5_HUMAN | |
| CD154 antigen | |
| tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome) | |
| tumor necrosis factor (ligand) superfamily, member V | |
| HIGM I | |
| hyper-IgM syndrome protein | |
| tumor necrosis factor 5 | |
| LOC84349 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 300386 |
|---|---|
| 308230 |
| Swiss-Prot Accession | P29965 |
|---|---|
| Q3L8U2 | |
| Q3LFI8 | |
| Q45QX2 | |
| P27548 | |
| Q0VEI3 | |
| Q9Z2V2 |
| Unigene ID | Hs.592244 |
|---|---|
| Mm.4861 | |
| Rn.44218 |
| KEGG ID | hsa:959 |
|---|---|
| mmu:21947 | |
| rno:84349 |
| Swiss-Prot ID | CD40L_HUMAN |
|---|---|
| CD40L_MOUSE | |
| CD40L_RAT | |
| Q0VEI3_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005174 |
|---|---|
| 0005125 | |
| 0005164 | |
| 0042100 | |
| 0006916 | |
| 0006955 | |
| 0006954 | |
| 0045190 | |
| 0007159 | |
| 0030168 | |
| 0032735 | |
| 0005576 | |
| 0005615 | |
| 0005887 | |
| 0005886 | |
| 0005625 | |
| 0030183 | |
| 0048305 | |
| 0051023 | |
| 0007165 | |
| 0016021 | |
| 0016020 | |
| 0003674 | |
| 0008150 | |
| 0005575 |
| IPI ID | IPI00024686 |
|---|---|
| IPI00643618 | |
| IPI00117673 | |
| IPI00210301 |
| Mouse chromosome position | X 18.0 cM |
|---|
| Homologene ID | 56 |
|---|
| MGI ID | 88337 |
|---|
| Rat chromosome position | Xq36 |
|---|
| RGD ID | 708418 |
|---|