| URN | urn:agi-llid:4321 |
|---|---|
| Connectivity | 183 |
| Name | MMP12 |
| Description | matrix metallopeptidase 12 (macrophage elastase) |
| Notes | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq] |
| Pathway | PPARG Targets |
|---|
| Ariadne Ontology | ECM degradation |
|---|
| GO Molecular Function | metal ion binding |
|---|---|
| calcium ion binding | |
| zinc ion binding | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| metalloendopeptidase activity |
| GO Cellular Component | extracellular region |
|---|---|
| proteinaceous extracellular matrix |
| GO Biological Process | metabolic process |
|---|---|
| positive regulation of epithelial cell proliferation | |
| proteolysis | |
| response to chemical stimulus | |
| response to drug |
| Group | ECM degradation |
|---|---|
| extracellular region | |
| proteinaceous extracellular matrix | |
| metal ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| metalloendopeptidase activity | |
| metabolic process | |
| positive regulation of epithelial cell proliferation | |
| proteolysis | |
| response to chemical stimulus | |
| response to drug |
| Hugo ID | 7158 |
|---|
| Human chromosome position | 11q22.3 |
|---|
| LocusLink ID | 4321 |
|---|---|
| 17381 | |
| 117033 |
| Alias | HME |
|---|---|
| MME | |
| MGC138506 | |
| matrix metalloproteinase 12 | |
| macrophage elastase | |
| macrophage metalloelastase | |
| matrix metalloproteinase 12 (macrophage elastase) | |
| Mmel | |
| AV378681 | |
| macrophage-metalloelastase | |
| matrix metallopeptidase 12 | |
| matrix metallopeptidase XII | |
| Macrophage metalloelastase precursor | |
| Matrix metalloproteinase-12 | |
| human macrophage metalloelastase | |
| metalloelastase | |
| human macrophage metalloelastases | |
| metalloelastases | |
| Mmp12 | |
| Matrix metalloproteinase XII | |
| matrix metallopeptidase 12 (macrophage elastase) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601046 |
|---|
| Swiss-Prot Accession | B2R9X8 |
|---|---|
| P39900 | |
| Q13165 | |
| Q99745 | |
| P34960 | |
| Q3TCW6 | |
| Q6GX99 | |
| Q8BJC0 | |
| Q63341 |
| Unigene ID | Hs.1695 |
|---|---|
| Mm.2055 | |
| Rn.33193 |
| KEGG ID | mmu:17381 |
|---|---|
| rno:117033 |
| EC Number | 3.4.24.65 |
|---|
| Swiss-Prot ID | MMP12_HUMAN |
|---|---|
| MMP12_MOUSE | |
| MMP12_RAT | |
| B2R9X8_HUMAN |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005509 |
|---|---|
| 0004222 | |
| 0008233 | |
| 0008270 | |
| 0008152 | |
| 0006508 | |
| 0005576 | |
| 0005578 | |
| 0016787 | |
| 0046872 | |
| 0008237 | |
| 0050679 | |
| 0042221 | |
| 0042493 |
| IPI ID | IPI00298246 |
|---|---|
| IPI00321648 | |
| IPI00881760 | |
| IPI00881624 | |
| IPI00403307 | |
| IPI00882065 | |
| IPI00199747 | |
| IPI00475653 |
| Mouse chromosome position | 9 1.0 cM |
|---|
| Homologene ID | 20547 |
|---|
| MGI ID | 97005 |
|---|
| Rat chromosome position | 8q11 |
|---|
| RGD ID | 620195 |
|---|