| URN | urn:agi-llid:4318 |
|---|---|
| Connectivity | 1339 |
| Name | MMP9 |
| Description | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
| Notes | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq] |
| Pathway | RARA Targets |
|---|---|
| PPARA Targets | |
| PPARD Targets | |
| PPARG Targets | |
| LXRA Targets | |
| LXRB Targets | |
| FXR Targets | |
| NURR1 Targets | |
| ERA Pathway | |
| GR Targets |
| Ariadne Ontology | ECM degradation |
|---|
| GO Molecular Function | protein binding |
|---|---|
| metal ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| fibronectin binding | |
| collagen binding | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| metalloendopeptidase activity |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space | |
| proteinaceous extracellular matrix |
| GO Biological Process | metabolic process |
|---|---|
| positive regulation of apoptosis | |
| positive regulation of keratinocyte migration | |
| positive regulation of leukocyte migration | |
| positive regulation of synaptic plasticity | |
| cell growth | |
| extracellular matrix organization | |
| macrophage differentiation | |
| ossification | |
| aging | |
| skeletal system development | |
| proteolysis | |
| collagen catabolic process | |
| response to lipopolysaccharide | |
| tissue remodeling | |
| response to mechanical stimulus | |
| response to radiation | |
| response to heat | |
| response to drug | |
| response to organic substance | |
| response to nutrient | |
| response to oxidative stress | |
| response to vitamin A | |
| response to ethanol | |
| response to organic cyclic substance | |
| response to hypoxia |
| Group | ECM degradation |
|---|---|
| extracellular region | |
| extracellular space | |
| proteinaceous extracellular matrix | |
| protein binding | |
| metal ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| fibronectin binding | |
| collagen binding | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| metalloendopeptidase activity | |
| metabolic process | |
| positive regulation of apoptosis | |
| positive regulation of keratinocyte migration | |
| positive regulation of leukocyte migration | |
| positive regulation of synaptic plasticity | |
| cell growth | |
| extracellular matrix organization | |
| macrophage differentiation | |
| ossification | |
| aging | |
| skeletal system development | |
| proteolysis | |
| collagen catabolic process | |
| response to lipopolysaccharide | |
| tissue remodeling | |
| response to mechanical stimulus | |
| response to radiation | |
| response to heat | |
| response to drug | |
| response to organic substance | |
| response to nutrient | |
| response to oxidative stress | |
| response to vitamin A | |
| response to ethanol | |
| response to organic cyclic substance | |
| response to hypoxia |
| Hugo ID | 7176 |
|---|
| Human chromosome position | 20q11.2-q13.1 |
|---|
| LocusLink ID | 4318 |
|---|---|
| 17395 | |
| 81687 |
| Alias | GELB |
|---|---|
| CLG4B | |
| MMP-9 | |
| matrix metalloproteinase 9 | |
| OTTHUMP00000031674 | |
| type V collagenase | |
| macrophage gelatinase | |
| matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | |
| B/MMP9 | |
| AW743869 | |
| pro-MMP-9 | |
| RP23-61O3.10 | |
| matrix metallopeptidase 9 | |
| Gel B | |
| gelatinase B | |
| 92kD gelatinase | |
| 92kDa gelatinase | |
| OTTMUSP00000001145 | |
| collagenase type IVB | |
| 92kD type IV collagenase | |
| 92kDa type IV collagenase | |
| 92-kDa type IV collagenase | |
| matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase) | |
| matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase) | |
| 2 kDa 9 type IV collagenase | |
| 92 kDa gelatinase | |
| 92 kDa type IV collagenase | |
| Mmp9 | |
| matrix metalloproteinase 9 preproprotein | |
| matrix metalloproteinase 9 (gelatinase b) | |
| matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | |
| matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase, 92kD type IV collagenase) | |
| B/MMP9s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 120361 |
|---|---|
| 603932 |
| Swiss-Prot Accession | P14780 |
|---|---|
| Q9UCJ9 | |
| Q9Y354 | |
| Q80XI8 | |
| P41245 | |
| Q2M4J5 | |
| Q3TTU7 | |
| Q3UQ52 | |
| Q6GXA2 | |
| Q91ZS5 | |
| Q9QWS6 | |
| P50282 |
| Unigene ID | Hs.297413 |
|---|---|
| Mm.4406 | |
| Rn.10209 |
| KEGG ID | mmu:17395 |
|---|---|
| rno:81687 |
| EC Number | 3.4.24.35 |
|---|
| Swiss-Prot ID | MMP9_HUMAN |
|---|---|
| MMP9_RAT | |
| Q80XI8_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005509 |
|---|---|
| 0005518 | |
| 0004222 | |
| 0008233 | |
| 0008270 | |
| 0030574 | |
| 0030198 | |
| 0030225 | |
| 0008152 | |
| 0043065 | |
| 0051549 | |
| 0006508 | |
| 0001501 | |
| 0005576 | |
| 0005615 | |
| 0005578 | |
| 0016787 | |
| 0046872 | |
| 0008237 | |
| 0005515 | |
| 0001968 | |
| 0007568 | |
| 0016049 | |
| 0001503 | |
| 0002687 | |
| 0031915 | |
| 0042493 | |
| 0045471 | |
| 0009408 | |
| 0001666 | |
| 0032496 | |
| 0009612 | |
| 0007584 | |
| 0014070 | |
| 0010033 | |
| 0006979 | |
| 0009314 | |
| 0033189 | |
| 0048771 |
| IPI ID | IPI00027509 |
|---|---|
| IPI00319200 | |
| IPI00330733 | |
| IPI00751342 | |
| IPI00196591 |
| Mouse chromosome position | 2 96.0 cM |
|---|
| Homologene ID | 3659 |
|---|
| MGI ID | 97011 |
|---|
| Rat chromosome position | 3q42 |
|---|
| RGD ID | 621320 |
|---|