Protein IL10

URN	urn:agi-llid:3586
Connectivity	1699
Name	IL10
Description	interleukin 10
Notes	The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. [provided by RefSeq]

Pathway	IL10R -> STAT signaling
	Common Regulators
	PPARA Targets
	PPARG Targets
	Common Regulators and Small Molecules

Ariadne Ontology	Cytokine

GO Molecular Function	protein binding
	cytokine activity
	interleukin-10 receptor binding

GO Cellular Component	extracellular region
	extracellular space

GO Biological Process	negative regulation of myeloid dendritic cell activation
	negative regulation of B cell proliferation
	negative regulation of T cell proliferation
	anti-apoptosis
	negative regulation of nitric oxide biosynthetic process
	negative regulation of interferon-alpha biosynthetic process
	negative regulation of tumor necrosis factor biosynthetic process
	negative regulation of membrane protein ectodomain proteolysis
	negative regulation of MHC class II biosynthetic process
	negative regulation of cytokine production
	negative regulation of interleukin-6 production
	negative regulation of interleukin-12 production
	negative regulation of inflammatory response
	cytoplasmic sequestering of NF-kappaB
	negative regulation of cytokine secretion during immune response
	positive regulation of B cell apoptosis
	positive regulation of MHC class II biosynthetic process
	positive regulation of cytokine secretion
	regulation of isotype switching
	regulation of gene expression
	regulation of sensory perception of pain
	B cell differentiation
	B cell proliferation
	cell-cell signaling
	leukocyte chemotaxis
	hemopoiesis
	immune response
	T-helper 2 type immune response
	receptor biosynthetic process
	response to molecule of bacterial origin
	defense response to bacterium
	response to stress
	response to glucocorticoid stimulus
	inflammatory response

Group	Cytokine
	extracellular region
	extracellular space
	protein binding
	cytokine activity
	interleukin-10 receptor binding
	negative regulation of myeloid dendritic cell activation
	negative regulation of B cell proliferation
	negative regulation of T cell proliferation
	anti-apoptosis
	negative regulation of nitric oxide biosynthetic process
	negative regulation of interferon-alpha biosynthetic process
	negative regulation of tumor necrosis factor biosynthetic process
	negative regulation of membrane protein ectodomain proteolysis
	negative regulation of MHC class II biosynthetic process
	negative regulation of cytokine production
	negative regulation of interleukin-6 production
	negative regulation of interleukin-12 production
	negative regulation of inflammatory response
	cytoplasmic sequestering of NF-kappaB
	negative regulation of cytokine secretion during immune response
	positive regulation of B cell apoptosis
	positive regulation of MHC class II biosynthetic process
	positive regulation of cytokine secretion
	regulation of isotype switching
	regulation of gene expression
	regulation of sensory perception of pain
	B cell differentiation
	B cell proliferation
	cell-cell signaling
	leukocyte chemotaxis
	hemopoiesis
	immune response
	T-helper 2 type immune response
	receptor biosynthetic process
	response to molecule of bacterial origin
	defense response to bacterium
	response to stress
	response to glucocorticoid stimulus
	inflammatory response

Hugo ID	5962

Human chromosome position	1q31-q32

Alias	CSIF
	TGIF
	IL-10
	IL10A
	MGC126450
	MGC126451
	interleukin 10
	cytokine synthesis inhibitory factor
	AL513351.1
	OTTMUSP00000017964
	IL10X
	SCH 52000
	Cytokine synthesis inhibitory factor
	IL10
	interleukin IL10
	IL10_HUMAN
	LOC113640
	DRG-0229
	rhuIL-10

OMIM ID	124092
	180300

Cell Localization	Extracellular

Mouse chromosome position	1 69.9 cM

Homologene ID	478

MGI ID	96537

Rat chromosome position	13q13

RGD ID	2886