| URN | urn:agi-llid:3553 |
|---|---|
| Connectivity | 2157 |
| Name | IL1B |
| Description | interleukin 1, beta |
| Notes | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq] |
| Pathway | IL1R -> STAT3 signaling |
|---|---|
| IL1R -> NF-kB signaling | |
| Common Regulators | |
| PPARG Targets | |
| TR3 Targets | |
| NR4A3 Targets | |
| Common Regulators and Small Molecules |
| Ariadne Ontology | IL1 family |
|---|
| GO Molecular Function | protein binding |
|---|---|
| growth factor activity | |
| cytokine activity | |
| interleukin-1 receptor binding |
| GO Cellular Component | extracellular region |
|---|---|
| secretory granule | |
| extracellular space | |
| vesicle |
| GO Biological Process | angiogenesis |
|---|---|
| positive regulation of angiogenesis | |
| negative regulation of cell proliferation | |
| negative regulation of glutamate secretion | |
| negative regulation of insulin receptor signaling pathway | |
| anti-apoptosis | |
| negative regulation of adiponectin secretion | |
| negative regulation of lipid metabolic process | |
| negative regulation of lipid catabolic process | |
| negative regulation of glucose transport | |
| positive regulation of T cell proliferation | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of JNK cascade | |
| positive regulation of stress-activated MAPK cascade | |
| positive regulation of mitosis | |
| positive regulation of apoptosis | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of interleukin-2 biosynthetic process | |
| positive regulation of chemokine biosynthetic process | |
| positive regulation of interleukin-6 biosynthetic process | |
| positive regulation of protein amino acid phosphorylation | |
| positive regulation of membrane protein ectodomain proteolysis | |
| positive regulation of T cell mediated immunity | |
| positive regulation of lipid catabolic process | |
| positive regulation of interleukin-6 production | |
| positive regulation vascular endothelial growth factor production | |
| signal transduction | |
| regulation of insulin secretion | |
| positive regulation of JUN kinase activity | |
| positive regulation of transcription factor activity | |
| negative regulation of MAP kinase activity | |
| activation of MAPK activity | |
| cytokine-mediated signaling pathway | |
| elevation of cytosolic calcium ion concentration | |
| fever | |
| sequestering of triglyceride | |
| cell proliferation | |
| cell-cell signaling | |
| apoptosis | |
| neutrophil chemotaxis | |
| leukocyte migration | |
| aging | |
| immune response | |
| chronic inflammatory response to antigenic stimulus | |
| social behavior | |
| response to lipopolysaccharide | |
| smooth muscle adaptation | |
| learning or memory | |
| memory | |
| response to chemical stimulus | |
| response to heat | |
| response to drug | |
| response to nutrient | |
| response to glucocorticoid stimulus | |
| response to estradiol stimulus | |
| response to vitamin D | |
| response to organic cyclic substance | |
| response to ATP | |
| response to morphine | |
| wound healing | |
| inflammatory response |
| Group | IL1 family |
|---|---|
| extracellular region | |
| secretory granule | |
| extracellular space | |
| vesicle | |
| protein binding | |
| growth factor activity | |
| cytokine activity | |
| interleukin-1 receptor binding | |
| angiogenesis | |
| positive regulation of angiogenesis | |
| negative regulation of cell proliferation | |
| negative regulation of glutamate secretion | |
| negative regulation of insulin receptor signaling pathway | |
| anti-apoptosis | |
| negative regulation of adiponectin secretion | |
| negative regulation of lipid metabolic process | |
| negative regulation of lipid catabolic process | |
| negative regulation of glucose transport | |
| positive regulation of T cell proliferation | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of JNK cascade | |
| positive regulation of stress-activated MAPK cascade | |
| positive regulation of mitosis | |
| positive regulation of apoptosis | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of interleukin-2 biosynthetic process | |
| positive regulation of chemokine biosynthetic process | |
| positive regulation of interleukin-6 biosynthetic process | |
| positive regulation of protein amino acid phosphorylation | |
| positive regulation of membrane protein ectodomain proteolysis | |
| positive regulation of T cell mediated immunity | |
| positive regulation of lipid catabolic process | |
| positive regulation of interleukin-6 production | |
| positive regulation vascular endothelial growth factor production | |
| signal transduction | |
| regulation of insulin secretion | |
| positive regulation of JUN kinase activity | |
| positive regulation of transcription factor activity | |
| negative regulation of MAP kinase activity | |
| activation of MAPK activity | |
| cytokine-mediated signaling pathway | |
| elevation of cytosolic calcium ion concentration | |
| fever | |
| sequestering of triglyceride | |
| cell proliferation | |
| cell-cell signaling | |
| apoptosis | |
| neutrophil chemotaxis | |
| leukocyte migration | |
| aging | |
| immune response | |
| chronic inflammatory response to antigenic stimulus | |
| social behavior | |
| response to lipopolysaccharide | |
| smooth muscle adaptation | |
| learning or memory | |
| memory | |
| response to chemical stimulus | |
| response to heat | |
| response to drug | |
| response to nutrient | |
| response to glucocorticoid stimulus | |
| response to estradiol stimulus | |
| response to vitamin D | |
| response to organic cyclic substance | |
| response to ATP | |
| response to morphine | |
| wound healing | |
| inflammatory response |
| Hugo ID | 5992 |
|---|
| Human chromosome position | 2q14 |
|---|
| LocusLink ID | 3553 |
|---|---|
| 16176 | |
| 24494 |
| Alias | IL-1 |
|---|---|
| IL1F2 | |
| IL1-BETA | |
| interleukin 1, beta | |
| catabolin | |
| preinterleukin 1 beta | |
| pro-interleukin-1-beta | |
| Il-1b | |
| IL-1beta | |
| RP23-384K11.2 | |
| OTTMUSP00000016525 | |
| IL-1 beta | |
| IL1B_HUMAN | |
| Interleukin IL1 beta | |
| IL1B | |
| IL1-ETA | |
| interleukin 1 beta | |
| interleukin-1 beta |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 147720 |
|---|---|
| 137215 |
| Swiss-Prot Accession | P01584 |
|---|---|
| O43645 | |
| P10749 | |
| Q2M4J6 | |
| Q3TI17 | |
| Q5BKB0 | |
| Q63264 |
| Unigene ID | Hs.126256 |
|---|---|
| Mm.222830 | |
| Rn.9869 |
| KEGG ID | hsa:3553 |
|---|---|
| mmu:16176 | |
| rno:24494 |
| Swiss-Prot ID | IL1B_HUMAN |
|---|---|
| IL1B_MOUSE | |
| Q2M4J6_MOUSE | |
| Q5BKB0_RAT |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005125 |
|---|---|
| 0005149 | |
| 0005515 | |
| 0000187 | |
| 0006916 | |
| 0006915 | |
| 0007267 | |
| 0019221 | |
| 0007204 | |
| 0001660 | |
| 0006955 | |
| 0006954 | |
| 0050900 | |
| 0043407 | |
| 0070164 | |
| 0008285 | |
| 0010829 | |
| 0046627 | |
| 0050995 | |
| 0030593 | |
| 0043123 | |
| 0046330 | |
| 0002711 | |
| 0042102 | |
| 0045766 | |
| 0045080 | |
| 0045086 | |
| 0045410 | |
| 0032755 | |
| 0050996 | |
| 0051044 | |
| 0045840 | |
| 0045429 | |
| 0001934 | |
| 0051091 | |
| 0010575 | |
| 0050796 | |
| 0033198 | |
| 0042221 | |
| 0032496 | |
| 0030730 | |
| 0007165 | |
| 0014805 | |
| 0005576 | |
| 0005615 | |
| 0031982 | |
| 0008083 | |
| 0008283 | |
| 0045833 | |
| 0030141 | |
| 0007568 | |
| 0001525 | |
| 0002439 | |
| 0007611 | |
| 0007613 | |
| 0014050 | |
| 0043507 | |
| 0043065 | |
| 0032874 | |
| 0042493 | |
| 0032355 | |
| 0051384 | |
| 0009408 | |
| 0043278 | |
| 0007584 | |
| 0014070 | |
| 0033280 | |
| 0035176 | |
| 0042060 |
| IPI ID | IPI00307223 |
|---|---|
| IPI00114067 | |
| IPI00206984 | |
| IPI00876594 |
| Mouse chromosome position | 2 73.0 cM |
|---|
| Homologene ID | 481 |
|---|
| MGI ID | 96543 |
|---|
| Rat chromosome position | 3q36 |
|---|
| RGD ID | 2891 |
|---|