| URN | urn:agi-llid:3162 |
|---|---|
| Connectivity | 755 |
| Name | HMOX1 |
| Description | heme oxygenase (decycling) 1 |
| Notes | Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq] |
| Pathway | PPARA Targets |
|---|---|
| PPARG Targets |
| Ariadne Ontology | Heme oxidation |
|---|
| GO Molecular Function | protein binding |
|---|---|
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| enzyme binding | |
| oxidoreductase activity | |
| phospholipase D activity | |
| heme oxygenase (decyclizing) activity | |
| signal transducer activity |
| GO Cellular Component | membrane fraction |
|---|---|
| microsome | |
| cytosol | |
| endoplasmic reticulum | |
| nucleus | |
| nucleolus | |
| plasma membrane | |
| caveola | |
| extracellular space |
| GO Biological Process | response to stimulus |
|---|---|
| angiogenesis | |
| regulation of angiogenesis | |
| negative regulation of cell proliferation | |
| negative regulation of mast cell degranulation | |
| positive regulation of anti-apoptosis | |
| negative regulation of leukocyte migration | |
| negative regulation of mast cell cytokine production | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| DNA damage response, signal transduction resulting in induction of apoptosis | |
| positive regulation of chemokine biosynthetic process | |
| positive regulation of vasodilation | |
| negative regulation of transcription factor activity | |
| regulation of transcription from RNA polymerase II promoter in response to oxidative stress | |
| intracellular signaling cascade | |
| small GTPase mediated signal transduction | |
| protein kinase cascade | |
| regulation of blood pressure | |
| iron ion homeostasis | |
| erythrocyte homeostasis | |
| negative regulation of DNA binding | |
| cell death | |
| cellular response to nutrient | |
| endothelial cell proliferation | |
| low-density lipoprotein particle clearance | |
| heme oxidation | |
| heme catabolic process | |
| phospholipid metabolic process | |
| excretion | |
| oxidation reduction | |
| smooth muscle hyperplasia | |
| response to oxidative stress | |
| response to estrogen stimulus | |
| response to nicotine | |
| response to hydrogen peroxide | |
| response to hypoxia | |
| healing during inflammatory response |
| Group | Heme oxidation |
|---|---|
| membrane fraction | |
| microsome | |
| cytosol | |
| endoplasmic reticulum | |
| nucleus | |
| nucleolus | |
| plasma membrane | |
| caveola | |
| extracellular space | |
| protein binding | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| enzyme binding | |
| oxidoreductase activity | |
| phospholipase D activity | |
| heme oxygenase (decyclizing) activity | |
| signal transducer activity | |
| response to stimulus | |
| angiogenesis | |
| regulation of angiogenesis | |
| negative regulation of cell proliferation | |
| negative regulation of mast cell degranulation | |
| positive regulation of anti-apoptosis | |
| negative regulation of leukocyte migration | |
| negative regulation of mast cell cytokine production | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| DNA damage response, signal transduction resulting in induction of apoptosis | |
| positive regulation of chemokine biosynthetic process | |
| positive regulation of vasodilation | |
| negative regulation of transcription factor activity | |
| regulation of transcription from RNA polymerase II promoter in response to oxidative stress | |
| intracellular signaling cascade | |
| small GTPase mediated signal transduction | |
| protein kinase cascade | |
| regulation of blood pressure | |
| iron ion homeostasis | |
| erythrocyte homeostasis | |
| negative regulation of DNA binding | |
| cell death | |
| cellular response to nutrient | |
| endothelial cell proliferation | |
| low-density lipoprotein particle clearance | |
| heme oxidation | |
| heme catabolic process | |
| phospholipid metabolic process | |
| excretion | |
| oxidation reduction | |
| smooth muscle hyperplasia | |
| response to oxidative stress | |
| response to estrogen stimulus | |
| response to nicotine | |
| response to hydrogen peroxide | |
| response to hypoxia | |
| healing during inflammatory response |
| Hugo ID | 5013 |
|---|
| Human chromosome position | 22q12 |
|---|
| LocusLink ID | 3162 |
|---|---|
| 15368 | |
| 24451 |
| Alias | HO-1 |
|---|---|
| HSP32 | |
| bK286B10 | |
| heme oxygenase (decyclizing) 1 | |
| OTTHUMP00000028925 | |
| HO1 | |
| Hmox | |
| Hemox | |
| D8Wsu38e | |
| hemoxygenase | |
| heme oxygenase 1 | |
| Heox | |
| HEOXG | |
| heme oxygenase (decycling) 1 | |
| HMOX1 | |
| heme oxygenase (decyclizing) I | |
| Heme oxygenase I | |
| HMOX I | |
| heme oxygenase (decycling) I | |
| LOC194477 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 141250 |
|---|---|
| 606963 |
| Swiss-Prot Accession | P09601 |
|---|---|
| Q6FH11 | |
| Q96DI8 | |
| P14901 | |
| Q3U5U6 | |
| Q3TVV4 | |
| Q3U5H8 | |
| P06762 |
| Unigene ID | Hs.517581 |
|---|---|
| Mm.276389 | |
| Rn.3160 |
| KEGG ID | hsa:3162 |
|---|---|
| mmu:15368 | |
| rno:24451 |
| EC Number | 1.14.99.3 |
|---|
| Swiss-Prot ID | HMOX1_HUMAN |
|---|---|
| HMOX1_MOUSE | |
| HMOX1_RAT | |
| Q6FH11_HUMAN | |
| Q3U5U6_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0019899 |
|---|---|
| 0020037 | |
| 0004392 | |
| 0046872 | |
| 0016491 | |
| 0004630 | |
| 0004871 | |
| 0008630 | |
| 0008219 | |
| 0031670 | |
| 0001935 | |
| 0034101 | |
| 0007588 | |
| 0002246 | |
| 0042167 | |
| 0006788 | |
| 0055072 | |
| 0034383 | |
| 0008285 | |
| 0002686 | |
| 0032764 | |
| 0043305 | |
| 0043433 | |
| 0055114 | |
| 0043123 | |
| 0045768 | |
| 0045080 | |
| 0045909 | |
| 0007243 | |
| 0045765 | |
| 0008217 | |
| 0043619 | |
| 0043627 | |
| 0042542 | |
| 0001666 | |
| 0035094 | |
| 0050896 | |
| 0007264 | |
| 0014806 | |
| 0005829 | |
| 0005783 | |
| 0005615 | |
| 0005624 | |
| 0005792 | |
| 0005730 | |
| 0005634 | |
| 0005506 | |
| 0005515 | |
| 0001525 | |
| 0007242 | |
| 0043392 | |
| 0006644 | |
| 0006979 | |
| 0005901 | |
| 0005886 |
| IPI ID | IPI00215893 |
|---|---|
| IPI00877645 | |
| IPI00131577 | |
| IPI00652020 | |
| IPI00206626 |
| Mouse chromosome position | 8 35.0 cM |
|---|
| Homologene ID | 31075 |
|---|
| MGI ID | 96163 |
|---|
| Rat chromosome position | 19p11 |
|---|
| RGD ID | 2806 |
|---|