| URN | urn:agi-llid:7040 |
|---|---|
| Connectivity | 2938 |
| Name | TGFB1 |
| Description | transforming growth factor, beta 1 |
| Notes | TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 (MIM 190220), and TGFB3 (MIM 190230) all function through the same receptor signaling systems.[supplied by OMIM] |
| Pathway | TGFBR -> AP-1 signaling |
|---|---|
| TGFBR -> SMAD1/5/9 signaling | |
| TGFBR -> ATF/GADD/MAX/TP53 signaling | |
| TGFBR -> CREB/ELK-SRF signaling | |
| TGFBR -> MEF/MYOD/MYOG signaling | |
| TGFBR/BMPR -> SMAD2/3 signaling | |
| Common Regulators | |
| RARA Targets | |
| PPARA Targets | |
| PPARD Targets | |
| PPARG Targets | |
| ERB Targets | |
| GR Targets | |
| MR Target Genes | |
| AR Targets | |
| Common Regulators and Small Molecules |
| Ariadne Ontology | TGF family |
|---|
| GO Molecular Function | protein binding |
|---|---|
| protein N-terminus binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| transforming growth factor beta receptor binding | |
| growth factor activity | |
| type II transforming growth factor beta receptor binding | |
| transcription activator activity |
| GO Cellular Component | extracellular region |
|---|---|
| cell soma | |
| cell surface | |
| axon | |
| cytoplasm | |
| secretory granule | |
| platelet alpha granule lumen | |
| Golgi lumen | |
| nucleus | |
| extracellular space | |
| extracellular matrix | |
| proteinaceous extracellular matrix |
| GO Biological Process | growth |
|---|---|
| SMAD protein complex assembly | |
| negative regulation of cell-cell adhesion | |
| negative regulation of cell proliferation | |
| negative regulation of cell growth | |
| negative regulation of release of sequestered calcium ion into cytosol | |
| negative regulation of T cell activation | |
| negative regulation of T cell proliferation | |
| negative regulation of mitotic cell cycle | |
| negative regulation of neuroblast proliferation | |
| negative regulation of blood vessel endothelial cell migration | |
| negative regulation of epithelial cell proliferation | |
| negative regulation of phagocytosis | |
| negative regulation of transcription | |
| negative regulation of DNA replication | |
| negative regulation of protein amino acid phosphorylation | |
| negative regulation of ossification | |
| negative regulation of immune response | |
| positive regulation of cell proliferation | |
| positive regulation of isotype switching to IgA isotypes | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of exit from mitosis | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| positive regulation of epithelial to mesenchymal transition | |
| positive regulation of fibroblast migration | |
| positive regulation of blood vessel endothelial cell migration | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein amino acid dephosphorylation | |
| positive regulation of pathway-restricted SMAD protein phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of peptidyl-threonine phosphorylation | |
| positive regulation of bone mineralization | |
| positive regulation of chemotaxis | |
| positive regulation of collagen biosynthetic process | |
| positive regulation of interleukin-17 production | |
| positive regulation of SMAD protein nuclear translocation | |
| regulation of cell growth | |
| regulation of cell differentiation | |
| regulation of cell proliferation | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| G1-S transition checkpoint | |
| regulation of cell migration | |
| regulation of protein import into nucleus | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of phosphoinositide 3-kinase activity | |
| positive regulation of MAP kinase activity | |
| transforming growth factor beta receptor signaling pathway | |
| pathway-restricted SMAD protein phosphorylation | |
| SMAD protein nuclear translocation | |
| epidermal growth factor receptor signaling pathway | |
| regulation of striated muscle development | |
| cellular calcium ion homeostasis | |
| myelination | |
| T cell homeostasis | |
| cell growth | |
| regulation of binding | |
| regulation of DNA binding | |
| cell death | |
| cell proliferation | |
| T cell activation | |
| T cell differentiation | |
| regulatory T cell differentiation | |
| myeloid dendritic cell differentiation | |
| cell cycle arrest | |
| germ cell migration | |
| mononuclear cell proliferation | |
| epithelial to mesenchymal transition | |
| foam cell differentiation | |
| protein amino acid phosphorylation | |
| ATP biosynthetic process | |
| phosphate metabolic process | |
| embryonic development | |
| aging | |
| inner ear development | |
| organ morphogenesis | |
| morphogenesis of a branching structure | |
| frontal suture morphogenesis | |
| salivary gland morphogenesis | |
| odontogenesis | |
| organ regeneration | |
| ossification involved in bone remodeling | |
| lung development | |
| gut development | |
| mammary gland development | |
| lymph node development | |
| skeletal muscle tissue development | |
| endoderm development | |
| skeletal system development | |
| defense response to fungus, incompatible interaction | |
| tolerance induction to self antigen | |
| female pregnancy | |
| evasion of host defenses by virus | |
| connective tissue replacement during inflammatory response | |
| response to radiation | |
| response to drug | |
| response to organic substance | |
| response to protein stimulus | |
| response to progesterone stimulus | |
| response to estradiol stimulus | |
| response to vitamin D | |
| response to organic cyclic substance | |
| response to hypoxia | |
| wound healing | |
| inflammatory response | |
| defense response | |
| response to laminar fluid shear stress |
| Group | TGF family |
|---|---|
| extracellular region | |
| cell soma | |
| cell surface | |
| axon | |
| cytoplasm | |
| secretory granule | |
| platelet alpha granule lumen | |
| Golgi lumen | |
| nucleus | |
| extracellular space | |
| extracellular matrix | |
| proteinaceous extracellular matrix | |
| protein binding | |
| protein N-terminus binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| transforming growth factor beta receptor binding | |
| growth factor activity | |
| type II transforming growth factor beta receptor binding | |
| transcription activator activity | |
| growth | |
| SMAD protein complex assembly | |
| negative regulation of cell-cell adhesion | |
| negative regulation of cell proliferation | |
| negative regulation of cell growth | |
| negative regulation of release of sequestered calcium ion into cytosol | |
| negative regulation of T cell activation | |
| negative regulation of T cell proliferation | |
| negative regulation of mitotic cell cycle | |
| negative regulation of neuroblast proliferation | |
| negative regulation of blood vessel endothelial cell migration | |
| negative regulation of epithelial cell proliferation | |
| negative regulation of phagocytosis | |
| negative regulation of transcription | |
| negative regulation of DNA replication | |
| negative regulation of protein amino acid phosphorylation | |
| negative regulation of ossification | |
| negative regulation of immune response | |
| positive regulation of cell proliferation | |
| positive regulation of isotype switching to IgA isotypes | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of exit from mitosis | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| positive regulation of epithelial to mesenchymal transition | |
| positive regulation of fibroblast migration | |
| positive regulation of blood vessel endothelial cell migration | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein amino acid dephosphorylation | |
| positive regulation of pathway-restricted SMAD protein phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of peptidyl-threonine phosphorylation | |
| positive regulation of bone mineralization | |
| positive regulation of chemotaxis | |
| positive regulation of collagen biosynthetic process | |
| positive regulation of interleukin-17 production | |
| positive regulation of SMAD protein nuclear translocation | |
| regulation of cell growth | |
| regulation of cell differentiation | |
| regulation of cell proliferation | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| G1-S transition checkpoint | |
| regulation of cell migration | |
| regulation of protein import into nucleus | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of phosphoinositide 3-kinase activity | |
| positive regulation of MAP kinase activity | |
| transforming growth factor beta receptor signaling pathway | |
| pathway-restricted SMAD protein phosphorylation | |
| SMAD protein nuclear translocation | |
| epidermal growth factor receptor signaling pathway | |
| regulation of striated muscle development | |
| cellular calcium ion homeostasis | |
| myelination | |
| T cell homeostasis | |
| cell growth | |
| regulation of binding | |
| regulation of DNA binding | |
| cell death | |
| cell proliferation | |
| T cell activation | |
| T cell differentiation | |
| regulatory T cell differentiation | |
| myeloid dendritic cell differentiation | |
| cell cycle arrest | |
| germ cell migration | |
| mononuclear cell proliferation | |
| epithelial to mesenchymal transition | |
| foam cell differentiation | |
| protein amino acid phosphorylation | |
| ATP biosynthetic process | |
| phosphate metabolic process | |
| embryonic development | |
| aging | |
| inner ear development | |
| organ morphogenesis | |
| morphogenesis of a branching structure | |
| frontal suture morphogenesis | |
| salivary gland morphogenesis | |
| odontogenesis | |
| organ regeneration | |
| ossification involved in bone remodeling | |
| lung development | |
| gut development | |
| mammary gland development | |
| lymph node development | |
| skeletal muscle tissue development | |
| endoderm development | |
| skeletal system development | |
| defense response to fungus, incompatible interaction | |
| tolerance induction to self antigen | |
| female pregnancy | |
| evasion of host defenses by virus | |
| connective tissue replacement during inflammatory response | |
| response to radiation | |
| response to drug | |
| response to organic substance | |
| response to protein stimulus | |
| response to progesterone stimulus | |
| response to estradiol stimulus | |
| response to vitamin D | |
| response to organic cyclic substance | |
| response to hypoxia | |
| wound healing | |
| inflammatory response | |
| defense response | |
| response to laminar fluid shear stress |
| Hugo ID | 11766 |
|---|
| Human chromosome position | 19q13.2 |
|---|
| LocusLink ID | 7040 |
|---|---|
| 21803 | |
| 59086 |
| Alias | CED |
|---|---|
| DPD1 | |
| TGFB | |
| TGFbeta | |
| transforming growth factor, beta 1 | |
| TGF-beta 1 protein | |
| transforming growth factor-beta 1 | |
| diaphyseal dysplasia 1, progressive | |
| Tgfb-1 | |
| TGFbeta1 | |
| TGF-beta1 | |
| TGF-beta 1 | |
| regulatory protein | |
| transforming growth factor beta-1 | |
| transforming growth factor, beta-1 | |
| TGF beta | |
| Tgfb1 | |
| Camurati-Engelmann disease protein | |
| TGF1_HUMAN | |
| TGF-beta I | |
| Transforming growth factor beta 1 precursor | |
| Camurati-Engelmann disease gene | |
| transforming growth factor, beta | |
| DPD I | |
| TGF eta | |
| beta 1 transforming growth factor | |
| TGF1_RAT | |
| Tgfb I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 190180 |
|---|---|
| 131300 | |
| 219700 |
| Swiss-Prot Accession | P01137 |
|---|---|
| Q49IK8 | |
| Q49IL8 | |
| Q5PY19 | |
| Q671U8 | |
| Q671V1 | |
| Q7Z487 | |
| Q7Z488 | |
| Q86YU2 | |
| P04202 | |
| Q3UNK5 | |
| P17246 | |
| Q9R231 |
| Unigene ID | Hs.645227 |
|---|---|
| Mm.248380 | |
| Rn.40136 |
| KEGG ID | mmu:21803 |
|---|---|
| rno:59086 |
| Swiss-Prot ID | TGFB1_HUMAN |
|---|---|
| TGFB1_MOUSE | |
| TGFB1_RAT | |
| Q3UNK5_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0008083 |
|---|---|
| 0047485 | |
| 0016563 | |
| 0005114 | |
| 0006754 | |
| 0031575 | |
| 0007183 | |
| 0043029 | |
| 0007050 | |
| 0008219 | |
| 0002248 | |
| 0009817 | |
| 0007173 | |
| 0019049 | |
| 0010742 | |
| 0008354 | |
| 0006917 | |
| 0006954 | |
| 0048535 | |
| 0030879 | |
| 0032943 | |
| 0001763 | |
| 0042552 | |
| 0043011 | |
| 0008156 | |
| 0042130 | |
| 0043537 | |
| 0030308 | |
| 0022408 | |
| 0050680 | |
| 0050777 | |
| 0045930 | |
| 0007406 | |
| 0030279 | |
| 0050765 | |
| 0001933 | |
| 0051280 | |
| 0016481 | |
| 0042476 | |
| 0043932 | |
| 0006796 | |
| 0043406 | |
| 0051092 | |
| 0060391 | |
| 0043536 | |
| 0030501 | |
| 0032270 | |
| 0050921 | |
| 0032967 | |
| 0050679 | |
| 0010718 | |
| 0031536 | |
| 0010763 | |
| 0032740 | |
| 0048298 | |
| 0010862 | |
| 0033138 | |
| 0010800 | |
| 0043552 | |
| 0035307 | |
| 0051897 | |
| 0045944 | |
| 0051101 | |
| 0045595 | |
| 0030334 | |
| 0042306 | |
| 0016202 | |
| 0017015 | |
| 0045066 | |
| 0042493 | |
| 0032355 | |
| 0001666 | |
| 0010033 | |
| 0032570 | |
| 0007435 | |
| 0001501 | |
| 0002513 | |
| 0042060 | |
| 0005796 | |
| 0030424 | |
| 0043025 | |
| 0005737 | |
| 0005576 | |
| 0005615 | |
| 0005634 | |
| 0031093 | |
| 0005578 | |
| 0030141 | |
| 0005515 | |
| 0005160 | |
| 0042110 | |
| 0030217 | |
| 0016049 | |
| 0008283 | |
| 0006874 | |
| 0006952 | |
| 0007492 | |
| 0040007 | |
| 0050868 | |
| 0008285 | |
| 0009887 | |
| 0060389 | |
| 0008284 | |
| 0045893 | |
| 0006468 | |
| 0051098 | |
| 0042127 | |
| 0051789 | |
| 0007519 | |
| 0007179 | |
| 0031012 | |
| 0046982 | |
| 0042803 | |
| 0007184 | |
| 0007568 | |
| 0009790 | |
| 0001837 | |
| 0007565 | |
| 0060364 | |
| 0048565 | |
| 0048839 | |
| 0030324 | |
| 0031100 | |
| 0043065 | |
| 0001558 | |
| 0034616 | |
| 0014070 | |
| 0009314 | |
| 0033280 | |
| 0009986 |
| IPI ID | IPI00000075 |
|---|---|
| IPI00114457 | |
| IPI00214538 |
| Mouse chromosome position | 7 6.5 cM |
|---|
| Homologene ID | 540 |
|---|
| MGI ID | 98725 |
|---|
| RGD ID | 69051 |
|---|