| URN | urn:agi-llid:7076 |
|---|---|
| Connectivity | 616 |
| Name | TIMP1 |
| Description | TIMP metallopeptidase inhibitor 1 |
| Notes | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq] |
| Pathway | PPARG Targets |
|---|---|
| FXR Targets | |
| SHP1 Targets |
| GO Molecular Function | protein binding |
|---|---|
| enzyme inhibitor activity | |
| metalloendopeptidase inhibitor activity |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular matrix | |
| proteinaceous extracellular matrix | |
| basement membrane |
| GO Biological Process | negative regulation of apoptosis |
|---|---|
| negative regulation of membrane protein ectodomain proteolysis | |
| positive regulation of cell proliferation | |
| erythrocyte maturation | |
| C21-steroid hormone biosynthetic process | |
| cell activation | |
| aging | |
| cartilage development | |
| response to organic substance | |
| response to cytokine stimulus | |
| response to peptide hormone stimulus | |
| wound healing |
| Group | extracellular region |
|---|---|
| extracellular matrix | |
| proteinaceous extracellular matrix | |
| basement membrane | |
| protein binding | |
| enzyme inhibitor activity | |
| metalloendopeptidase inhibitor activity | |
| negative regulation of apoptosis | |
| negative regulation of membrane protein ectodomain proteolysis | |
| positive regulation of cell proliferation | |
| erythrocyte maturation | |
| C21-steroid hormone biosynthetic process | |
| cell activation | |
| aging | |
| cartilage development | |
| response to organic substance | |
| response to cytokine stimulus | |
| response to peptide hormone stimulus | |
| wound healing |
| Hugo ID | 11820 |
|---|
| Human chromosome position | Xp11.3-p11.23 |
|---|
| LocusLink ID | 7076 |
|---|---|
| 21857 | |
| 116510 |
| Alias | EPA |
|---|---|
| EPO | |
| HCI | |
| CLGI | |
| TIMP | |
| FLJ90373 | |
| RP1-230G1.3 | |
| tissue inhibitor of metalloproteinase 1 | |
| OTTHUMP00000023214 | |
| erythroid potentiating activity | |
| fibroblast collagenase inhibitor | |
| TIMP-1 | |
| MGC7143 | |
| RP23-132C19.3 | |
| OTTMUSP00000018691 | |
| OTTMUSP00000018692 | |
| tissue inhibitor of metalloproteinase-1 | |
| TIMP metallopeptidase inhibitor 1 | |
| tissue inhibitor of metallopeptidase 1 | |
| Collagenase inhibitor | |
| Erythroid potentiating activity | |
| Erythroid-potentiating activity (tissue inhibitor of metalloproteinases) | |
| Metalloproteinase inhibitor 1 precursor | |
| metalloproteinase tissue inhibitor 1 precursor | |
| TIM1_HUMAN | |
| Timp1 | |
| Tissue inhibitor of metalloproteinases | |
| tissue inhibitor of metalloproteinase I | |
| Timp I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 305370 |
|---|
| Swiss-Prot Accession | P01033 |
|---|---|
| Q6FGX5 | |
| Q58P21 | |
| Q5H9A7 | |
| B1AUP1 | |
| P12032 | |
| Q60734 | |
| Q6GXA9 | |
| P30120 | |
| Q91ZP7 |
| Unigene ID | Hs.522632 |
|---|---|
| Mm.8245 | |
| Rn.25754 |
| KEGG ID | mmu:21857 |
|---|---|
| rno:116510 |
| Swiss-Prot ID | TIMP1_HUMAN |
|---|---|
| TIMP1_MOUSE | |
| TIMP1_RAT | |
| Q6FGX5_HUMAN | |
| B1AUP1_MOUSE |
| GO ID | 0004857 |
|---|---|
| 0008191 | |
| 0005515 | |
| 0043249 | |
| 0051045 | |
| 0008284 | |
| 0005576 | |
| 0005578 | |
| 0005604 | |
| 0006700 | |
| 0007568 | |
| 0051216 | |
| 0001775 | |
| 0043066 | |
| 0034097 | |
| 0010033 | |
| 0043434 | |
| 0042060 | |
| 0031012 |
| IPI ID | IPI00032292 |
|---|---|
| IPI00552089 | |
| IPI00642739 | |
| IPI00639839 | |
| IPI00552339 | |
| IPI00114403 | |
| IPI00458763 | |
| IPI00205805 |
| Mouse chromosome position | X 6.2 cM |
|---|
| Homologene ID | 36321 |
|---|
| MGI ID | 98752 |
|---|
| Rat chromosome position | Xq12 |
|---|
| RGD ID | 621675 |
|---|