| URN | urn:agi-llid:847 |
|---|---|
| Connectivity | 896 |
| Name | CAT |
| Description | catalase |
| Notes | functions as a hydrogen peroxide:hydrogen peroxide reductase [RGD] |
| Pathway | PPARA Targets |
|---|---|
| PPARD Targets | |
| PPARG Targets |
| Ariadne Ontology | Aromatic aminoacid metabolism |
|---|---|
| ROS catabolism |
| GO Molecular Function | peroxidase activity |
|---|---|
| catalase activity | |
| NADP or NADPH binding | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| protein homodimerization activity | |
| growth factor activity | |
| oxidoreductase activity | |
| aminoacylase activity | |
| oxidoreductase activity, acting on peroxide as acceptor |
| GO Cellular Component | mitochondrion |
|---|---|
| cytosol | |
| Golgi apparatus | |
| endoplasmic reticulum | |
| peroxisome | |
| peroxisomal membrane | |
| mitochondrial intermembrane space | |
| lysosome | |
| plasma membrane |
| GO Biological Process | protein tetramerization |
|---|---|
| negative regulation of apoptosis | |
| positive regulation of phosphoinositide 3-kinase cascade | |
| negative regulation of NF-kappaB transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| cell proliferation | |
| cholesterol metabolic process | |
| hydrogen peroxide catabolic process | |
| triglyceride metabolic process | |
| hemoglobin metabolic process | |
| aerobic respiration | |
| oxidation reduction | |
| UV protection | |
| response to oxidative stress | |
| response to reactive oxygen species |
| Group | Aromatic aminoacid metabolism |
|---|---|
| ROS catabolism | |
| mitochondrion | |
| cytosol | |
| Golgi apparatus | |
| endoplasmic reticulum | |
| peroxisome | |
| peroxisomal membrane | |
| mitochondrial intermembrane space | |
| lysosome | |
| plasma membrane | |
| peroxidase activity | |
| catalase activity | |
| NADP or NADPH binding | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| protein homodimerization activity | |
| growth factor activity | |
| oxidoreductase activity | |
| aminoacylase activity | |
| oxidoreductase activity, acting on peroxide as acceptor | |
| protein tetramerization | |
| negative regulation of apoptosis | |
| positive regulation of phosphoinositide 3-kinase cascade | |
| negative regulation of NF-kappaB transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| cell proliferation | |
| cholesterol metabolic process | |
| hydrogen peroxide catabolic process | |
| triglyceride metabolic process | |
| hemoglobin metabolic process | |
| aerobic respiration | |
| oxidation reduction | |
| UV protection | |
| response to oxidative stress | |
| response to reactive oxygen species |
| Hugo ID | 1516 |
|---|
| Human chromosome position | 11p13 |
|---|
| LocusLink ID | 847 |
|---|---|
| 12359 | |
| 24248 |
| Alias | MGC138422 |
|---|---|
| MGC138424 | |
| catalase | |
| Cas1 | |
| Cs-1 | |
| Cas-1 | |
| 2210418N07 | |
| RP23-266F3.2 | |
| catalase 1 | |
| OTTMUSP00000015802 | |
| CS1 | |
| RATCATL | |
| RATCAT01 | |
| catalase I | |
| CGI-01 | |
| RATCATLs | |
| 5630401D24Rik | |
| KIAA0859 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 115500 |
|---|
| Swiss-Prot Accession | P04040 |
|---|---|
| Q8TAK2 | |
| Q3TXQ6 | |
| P24270 | |
| Q3TVZ1 | |
| Q3UF58 | |
| Q3UZE7 | |
| Q542K4 | |
| Q8C6E3 | |
| Q91XI2 | |
| P04762 |
| Unigene ID | Hs.502302 |
|---|---|
| Mm.4215 | |
| Rn.3001 |
| KEGG ID | hsa:847 |
|---|---|
| mmu:12359 | |
| rno:24248 |
| EC Number | 1.11.1.6 |
|---|
| Swiss-Prot ID | CATA_HUMAN |
|---|---|
| CATA_RAT | |
| Q3TXQ6_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0050661 |
|---|---|
| 0004046 | |
| 0004096 | |
| 0008083 | |
| 0020037 | |
| 0046872 | |
| 0042803 | |
| 0009650 | |
| 0009060 | |
| 0008283 | |
| 0008203 | |
| 0020027 | |
| 0042744 | |
| 0032088 | |
| 0043066 | |
| 0055114 | |
| 0051092 | |
| 0014068 | |
| 0051262 | |
| 0000302 | |
| 0006641 | |
| 0005739 | |
| 0005778 | |
| 0005777 | |
| 0005506 | |
| 0016491 | |
| 0016684 | |
| 0004601 | |
| 0006979 | |
| 0005794 | |
| 0005829 | |
| 0005783 | |
| 0005764 | |
| 0005758 | |
| 0005886 |
| IPI ID | IPI00465436 |
|---|---|
| IPI00312058 | |
| IPI00869393 | |
| IPI00755311 | |
| IPI00231742 |
| Mouse chromosome position | 2 57.0 cM |
|---|
| Homologene ID | 55514 |
|---|
| MGI ID | 88271 |
|---|
| Rat chromosome position | 3q32-q34 |
|---|
| RGD ID | 2279 |
|---|