Protein IL2

URN	urn:agi-llid:3558
Connectivity	2215
Name	IL2
Description	interleukin 2
Notes	The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq]

Pathway	IL2R -> STAT signaling
	IL2R -> ELK-SRF/MYC signaling
	Common Regulators
	RARA Targets
	PPARA Targets
	PPARG Targets
	RORG Targets
	VDR Targets
	NR2C1 Targets
	EAR2 Targets
	Common Regulators and Small Molecules

Ariadne Ontology	Cytokine

GO Molecular Function	protein binding
	carbohydrate binding
	glycosphingolipid binding
	growth factor activity
	cytokine activity
	kappa-type opioid receptor binding
	interleukin-2 receptor binding
	kinase activator activity

GO Cellular Component	extracellular region
	extracellular space

GO Biological Process	cell adhesion
	negative regulation of lymphocyte proliferation
	anti-apoptosis
	negative regulation of B cell apoptosis
	negative regulation of protein amino acid phosphorylation
	negative regulation of heart contraction
	negative regulation of inflammatory response
	positive regulation of cell proliferation
	positive regulation of cell growth
	positive regulation of B cell proliferation
	positive regulation of isotype switching to IgG isotypes
	positive regulation of T cell differentiation
	positive regulation of regulatory T cell differentiation
	positive regulation of T cell proliferation
	positive regulation of activated T cell proliferation
	positive regulation of tyrosine phosphorylation of Stat5 protein
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of protein amino acid phosphorylation
	positive regulation of immunoglobulin secretion
	regulation of T cell homeostatic proliferation
	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
	G-protein coupled receptor protein signaling pathway
	elevation of cytosolic calcium ion concentration
	natural killer cell activation
	T cell differentiation
	cell-cell signaling
	immune response

Group	Cytokine
	extracellular region
	extracellular space
	protein binding
	carbohydrate binding
	glycosphingolipid binding
	growth factor activity
	cytokine activity
	kappa-type opioid receptor binding
	interleukin-2 receptor binding
	kinase activator activity
	cell adhesion
	negative regulation of lymphocyte proliferation
	anti-apoptosis
	negative regulation of B cell apoptosis
	negative regulation of protein amino acid phosphorylation
	negative regulation of heart contraction
	negative regulation of inflammatory response
	positive regulation of cell proliferation
	positive regulation of cell growth
	positive regulation of B cell proliferation
	positive regulation of isotype switching to IgG isotypes
	positive regulation of T cell differentiation
	positive regulation of regulatory T cell differentiation
	positive regulation of T cell proliferation
	positive regulation of activated T cell proliferation
	positive regulation of tyrosine phosphorylation of Stat5 protein
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of protein amino acid phosphorylation
	positive regulation of immunoglobulin secretion
	regulation of T cell homeostatic proliferation
	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
	G-protein coupled receptor protein signaling pathway
	elevation of cytosolic calcium ion concentration
	natural killer cell activation
	T cell differentiation
	cell-cell signaling
	immune response

Hugo ID	6001

Human chromosome position	4q26-q27

Alias	IL-2
	TCGF
	lymphokine
	interleukin 2
	aldesleukin
	interleukin-2
	T cell growth factor
	involved in regulation of T-cell clonal expansion
	DN-144H19.3
	OTTMUSP00000007837
	IL2_HUMAN
	interleukin IL2
	T-cell growth factor
	IL II
	interleukin [il]-2
	IL2
	interleukin II

OMIM ID	147680

Cell Localization	Extracellular

Mouse chromosome position	3 19.2 cM

Homologene ID	488

MGI ID	96548

Rat chromosome position	2q25

RGD ID	620047