| URN | urn:agi-llid:2335 |
|---|---|
| Connectivity | 1617 |
| Name | FN1 |
| Description | fibronectin 1 |
| Notes | This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq] |
| Pathway | FibronectinR -> ICAP-1A/MYC signaling |
|---|---|
| FibronectinR -> NF-kB signaling | |
| FibronectinR -> CTNNB signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| Common Regulators | |
| RARA Targets | |
| PPARG Targets | |
| NR2E1 Targets | |
| GR Targets | |
| PGR Targets |
| Ariadne Ontology | ECM-Cell adhesion proteins |
|---|
| GO Molecular Function | protein binding |
|---|---|
| heparin binding | |
| mercury ion binding | |
| collagen binding | |
| protease binding | |
| peptidase activator activity | |
| extracellular matrix structural constituent |
| GO Cellular Component | extracellular region |
|---|---|
| apical plasma membrane | |
| ER-Golgi intermediate compartment | |
| platelet alpha granule lumen | |
| fibrinogen complex | |
| extracellular matrix | |
| proteinaceous extracellular matrix | |
| basement membrane |
| GO Biological Process | cell-substrate junction assembly |
|---|---|
| cell adhesion | |
| cell-matrix adhesion | |
| anti-apoptosis | |
| regulation of cell shape | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| cell migration | |
| extracellular matrix organization | |
| peptide cross-linking | |
| ossification | |
| response to wounding | |
| wound healing | |
| acute-phase response |
| Group | ECM-Cell adhesion proteins |
|---|---|
| extracellular region | |
| apical plasma membrane | |
| ER-Golgi intermediate compartment | |
| platelet alpha granule lumen | |
| fibrinogen complex | |
| extracellular matrix | |
| proteinaceous extracellular matrix | |
| basement membrane | |
| protein binding | |
| heparin binding | |
| mercury ion binding | |
| collagen binding | |
| protease binding | |
| peptidase activator activity | |
| extracellular matrix structural constituent | |
| cell-substrate junction assembly | |
| cell adhesion | |
| cell-matrix adhesion | |
| anti-apoptosis | |
| regulation of cell shape | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| cell migration | |
| extracellular matrix organization | |
| peptide cross-linking | |
| ossification | |
| response to wounding | |
| wound healing | |
| acute-phase response |
| Hugo ID | 3778 |
|---|
| Human chromosome position | 2q34 |
|---|
| LocusLink ID | 2335 |
|---|---|
| 14268 | |
| 25661 |
| Alias | FN |
|---|---|
| CIG | |
| FNZ | |
| MSF | |
| ED-B | |
| FINC | |
| GFND | |
| LETS | |
| GFND2 | |
| DKFZp686H0342 | |
| DKFZp686I1370 | |
| DKFZp686F10164 | |
| DKFZp686O13149 | |
| fibronectin 1 | |
| cold-insoluble globulin | |
| migration-stimulating factor | |
| Fn-1 | |
| MGC117493 | |
| E330027I09 | |
| FIBNEC | |
| fibronectin I | |
| fibronectin | |
| glomerulopathy with fibronectin deposits protein | |
| FN1 | |
| FN I | |
| glomerulopathy with fibronectin deposits gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 135600 |
|---|---|
| 601894 |
| Swiss-Prot Accession | P02751 |
|---|---|
| Q6MZF4 | |
| O95608 | |
| O95617 | |
| Q14327 | |
| Q14328 | |
| Q53S27 | |
| Q564H7 | |
| Q59G22 | |
| Q5CZ99 | |
| Q68CX6 | |
| Q6MZM7 | |
| Q6MZS0 | |
| Q6N084 | |
| Q6PJE5 | |
| Q7L553 | |
| Q7Z391 | |
| Q9H382 | |
| Q9UQS6 | |
| P11276 | |
| Q3TBB4 | |
| Q3TCF1 | |
| Q3TCL7 | |
| Q3UGY5 | |
| Q3UH17 | |
| Q3UHL6 | |
| Q3UHR1 | |
| Q3UZF9 | |
| Q4KL80 | |
| Q8R3F3 | |
| Q99KD0 | |
| Q9Z1Z7 | |
| Q9Z1Z8 | |
| P04937 | |
| P97624 | |
| Q6LC76 | |
| Q9Z1G8 |
| Unigene ID | Hs.203717 |
|---|---|
| Mm.193099 | |
| Rn.1604 |
| KEGG ID | rno:25661 |
|---|
| Swiss-Prot ID | FINC_HUMAN |
|---|---|
| Q6MZF4_HUMAN |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005518 |
|---|---|
| 0005201 | |
| 0008201 | |
| 0006953 | |
| 0007155 | |
| 0016477 | |
| 0018149 | |
| 0008360 | |
| 0009611 | |
| 0007169 | |
| 0005793 | |
| 0005576 | |
| 0005577 | |
| 0031093 | |
| 0005578 | |
| 0016504 | |
| 0005515 | |
| 0007160 | |
| 0007044 | |
| 0042060 | |
| 0016324 | |
| 0005604 | |
| 0031012 | |
| 0045340 | |
| 0002020 | |
| 0006916 | |
| 0030198 | |
| 0001503 |
| IPI ID | IPI00022418 |
|---|---|
| IPI00479723 | |
| IPI00339319 | |
| IPI00556632 | |
| IPI00867588 | |
| IPI00855777 | |
| IPI00855785 | |
| IPI00411462 | |
| IPI00339223 | |
| IPI00339224 | |
| IPI00339225 | |
| IPI00339226 | |
| IPI00339227 | |
| IPI00339228 | |
| IPI00383776 | |
| IPI00873210 | |
| IPI00845263 | |
| IPI00414283 | |
| IPI00113539 | |
| IPI00352163 | |
| IPI00652813 | |
| IPI00652571 | |
| IPI00200757 | |
| IPI00231982 | |
| IPI00231983 | |
| IPI00231984 | |
| IPI00208859 |
| Mouse chromosome position | 1 36.1 cM |
|---|
| Homologene ID | 1533 |
|---|
| MGI ID | 95566 |
|---|
| Rat chromosome position | 9q33 |
|---|
| RGD ID | 2624 |
|---|