| URN | urn:agi-llid:6648 |
|---|---|
| Connectivity | 513 |
| Name | SOD2 |
| Description | superoxide dismutase 2, mitochondrial |
| Notes | This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] |
| Pathway | PPARG Targets |
|---|
| Ariadne Ontology | ROS catabolism |
|---|
| GO Molecular Function | protein binding |
|---|---|
| oxygen binding | |
| metal ion binding | |
| manganese ion binding | |
| oxidoreductase activity | |
| superoxide dismutase activity |
| GO Cellular Component | soluble fraction |
|---|---|
| cytoplasm | |
| mitochondrion | |
| mitochondrial matrix | |
| mitochondrial inner membrane |
| GO Biological Process | negative regulation of apoptosis |
|---|---|
| anti-apoptosis | |
| negative regulation of neuron apoptosis | |
| negative regulation of fat cell differentiation | |
| negative regulation of fibroblast proliferation | |
| positive regulation of nitric oxide biosynthetic process | |
| regulation of transcription from RNA polymerase II promoter | |
| regulation of blood pressure | |
| regulation of mitochondrial membrane potential | |
| oxygen homeostasis | |
| iron ion homeostasis | |
| vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure | |
| vasodilation | |
| regulation of catalytic activity | |
| apoptosis | |
| release of cytochrome c from mitochondria | |
| mitochondrion organization | |
| neuron development | |
| erythrophore differentiation | |
| hydrogen peroxide biosynthetic process | |
| double-strand break repair | |
| glutathione metabolic process | |
| respiratory electron transport chain | |
| hydrogen peroxide metabolic process | |
| superoxide metabolic process | |
| removal of superoxide radicals | |
| superoxide release | |
| aging | |
| post-embryonic development | |
| age-dependent response to oxidative stress | |
| organ senescence | |
| heart development | |
| liver development | |
| hemopoiesis | |
| oxidation reduction | |
| sensory perception of sound | |
| response to stress | |
| response to activity | |
| locomotory behavior | |
| detection of oxygen | |
| response to gamma radiation | |
| response to drug | |
| response to oxidative stress | |
| response to reactive oxygen species | |
| age-dependent response to reactive oxygen species | |
| response to hydrogen peroxide | |
| response to superoxide | |
| response to hyperoxia | |
| response to hypoxia | |
| response to nutrient levels | |
| response to axon injury |
| Group | ROS catabolism |
|---|---|
| soluble fraction | |
| cytoplasm | |
| mitochondrion | |
| mitochondrial matrix | |
| mitochondrial inner membrane | |
| protein binding | |
| oxygen binding | |
| metal ion binding | |
| manganese ion binding | |
| oxidoreductase activity | |
| superoxide dismutase activity | |
| negative regulation of apoptosis | |
| anti-apoptosis | |
| negative regulation of neuron apoptosis | |
| negative regulation of fat cell differentiation | |
| negative regulation of fibroblast proliferation | |
| positive regulation of nitric oxide biosynthetic process | |
| regulation of transcription from RNA polymerase II promoter | |
| regulation of blood pressure | |
| regulation of mitochondrial membrane potential | |
| oxygen homeostasis | |
| iron ion homeostasis | |
| vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure | |
| vasodilation | |
| regulation of catalytic activity | |
| apoptosis | |
| release of cytochrome c from mitochondria | |
| mitochondrion organization | |
| neuron development | |
| erythrophore differentiation | |
| hydrogen peroxide biosynthetic process | |
| double-strand break repair | |
| glutathione metabolic process | |
| respiratory electron transport chain | |
| hydrogen peroxide metabolic process | |
| superoxide metabolic process | |
| removal of superoxide radicals | |
| superoxide release | |
| aging | |
| post-embryonic development | |
| age-dependent response to oxidative stress | |
| organ senescence | |
| heart development | |
| liver development | |
| hemopoiesis | |
| oxidation reduction | |
| sensory perception of sound | |
| response to stress | |
| response to activity | |
| locomotory behavior | |
| detection of oxygen | |
| response to gamma radiation | |
| response to drug | |
| response to oxidative stress | |
| response to reactive oxygen species | |
| age-dependent response to reactive oxygen species | |
| response to hydrogen peroxide | |
| response to superoxide | |
| response to hyperoxia | |
| response to hypoxia | |
| response to nutrient levels | |
| response to axon injury |
| Hugo ID | 11180 |
|---|
| Human chromosome position | 6q25.3 |
|---|
| LocusLink ID | 6648 |
|---|---|
| 20656 | |
| 24787 |
| Alias | IPO-B |
|---|---|
| MNSOD | |
| Mn-SOD | |
| manganese superoxide dismutase | |
| OTTHUMP00000017530 | |
| OTTHUMP00000017531 | |
| indophenoloxidase B | |
| Mn superoxide dismutase | |
| mangano-superoxide dismutase | |
| manganese-containing superoxide dismutase | |
| Sod-2 | |
| MGC6144 | |
| superoxide dismutase 2, mitochondrial | |
| manganese SOD | |
| superoxide dismutase 2 | |
| Superoxide dimutase 2, mitochondrial | |
| mitochondrial Superoxide dimutase 2 | |
| mitochondrial Superoxide dismutase (Mn) precursor | |
| mitochondrial Superoxide dimutase II | |
| mitochondrial superoxide dismutase II | |
| mitochondrial superoxide dismutase 2 | |
| SOD2 | |
| Superoxide dimutase 2 mitochondrial | |
| Superoxide dismutase (Mn), mitochondrial precursor | |
| MGC5618 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 147460 |
|---|
| Swiss-Prot Accession | B2R7R1 |
|---|---|
| P04179 | |
| B4DL20 | |
| Q4ZJI1 | |
| Q5TCM0 | |
| Q6LE88 | |
| Q6LEN1 | |
| Q7Z7M4 | |
| Q7Z7M5 | |
| Q7Z7M6 | |
| Q7Z7M7 | |
| Q96AM7 | |
| Q9UG59 | |
| P09671 | |
| Q4FJX9 | |
| Q3TJA2 | |
| Q3U8W4 | |
| P07895 |
| Unigene ID | Hs.487046 |
|---|---|
| Mm.290876 | |
| Rn.10488 |
| KEGG ID | hsa:6648 |
|---|---|
| mmu:20656 | |
| rno:24787 |
| EC Number | 1.15.1.1 |
|---|
| Swiss-Prot ID | SODM_HUMAN |
|---|---|
| SODM_MOUSE | |
| SODM_RAT | |
| B2R7R1_HUMAN | |
| B4DL20_HUMAN | |
| Q4FJX9_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0030145 |
|---|---|
| 0046872 | |
| 0016491 | |
| 0005515 | |
| 0004784 | |
| 0001306 | |
| 0001315 | |
| 0003032 | |
| 0006302 | |
| 0048773 | |
| 0006749 | |
| 0007507 | |
| 0030097 | |
| 0055072 | |
| 0001889 | |
| 0007626 | |
| 0007005 | |
| 0045599 | |
| 0048147 | |
| 0043524 | |
| 0048666 | |
| 0010260 | |
| 0055114 | |
| 0032364 | |
| 0045429 | |
| 0009791 | |
| 0008217 | |
| 0050790 | |
| 0051881 | |
| 0006357 | |
| 0001836 | |
| 0019430 | |
| 0022904 | |
| 0014823 | |
| 0048678 | |
| 0010332 | |
| 0042542 | |
| 0055093 | |
| 0000303 | |
| 0042554 | |
| 0003069 | |
| 0005743 | |
| 0005759 | |
| 0005739 | |
| 0006915 | |
| 0043066 | |
| 0006979 | |
| 0000302 | |
| 0007605 | |
| 0006801 | |
| 0042311 | |
| 0019825 | |
| 0007568 | |
| 0006916 | |
| 0050665 | |
| 0042743 | |
| 0042493 | |
| 0001666 | |
| 0031667 | |
| 0006950 | |
| 0005737 | |
| 0005625 |
| IPI ID | IPI00022314 |
|---|---|
| IPI00896370 | |
| IPI00607577 | |
| IPI00847322 | |
| IPI00109109 | |
| IPI00211593 |
| Mouse chromosome position | 17 7.6 cM |
|---|
| Homologene ID | 530 |
|---|
| MGI ID | 98352 |
|---|
| Rat chromosome position | 1q21 |
|---|
| RGD ID | 3732 |
|---|