| URN | urn:agi-llid:6352 |
|---|---|
| Connectivity | 777 |
| Name | CCL5 |
| Description | chemokine (C-C motif) ligand 5 |
| Notes | This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. [provided by RefSeq] |
| Pathway | CCR5 -> TP53 signaling |
|---|---|
| CCR1 -> STAT signaling | |
| CCR2/5 -> STAT signaling | |
| PPARA Targets | |
| PPARG Targets | |
| ERA Pathway | |
| GR Targets |
| Ariadne Ontology | Chemokines |
|---|
| GO Molecular Function | chemoattractant activity |
|---|---|
| cytokine activity | |
| chemokine activity | |
| signal transducer activity |
| GO Cellular Component | extracellular region |
|---|---|
| soluble fraction | |
| cytoplasm | |
| extracellular space |
| GO Biological Process | cell adhesion |
|---|---|
| negative regulation of viral genome replication | |
| positive regulation of osteoclast differentiation | |
| signal transduction | |
| cellular calcium ion homeostasis | |
| cell motion | |
| cell-cell signaling | |
| lymphocyte chemotaxis | |
| exocytosis | |
| immune response | |
| chemotaxis | |
| response to virus | |
| response to cytokine stimulus | |
| response to oxidative stress | |
| response to tumor necrosis factor | |
| inflammatory response | |
| cellular defense response |
| Group | Chemokines |
|---|---|
| extracellular region | |
| soluble fraction | |
| cytoplasm | |
| extracellular space | |
| chemoattractant activity | |
| cytokine activity | |
| chemokine activity | |
| signal transducer activity | |
| cell adhesion | |
| negative regulation of viral genome replication | |
| positive regulation of osteoclast differentiation | |
| signal transduction | |
| cellular calcium ion homeostasis | |
| cell motion | |
| cell-cell signaling | |
| lymphocyte chemotaxis | |
| exocytosis | |
| immune response | |
| chemotaxis | |
| response to virus | |
| response to cytokine stimulus | |
| response to oxidative stress | |
| response to tumor necrosis factor | |
| inflammatory response | |
| cellular defense response |
| Hugo ID | 10632 |
|---|
| Human chromosome position | 17q11.2-q12 |
|---|
| LocusLink ID | 6352 |
|---|---|
| 20304 | |
| 81780 |
| Alias | SISd |
|---|---|
| SCYA5 | |
| RANTES | |
| TCP228 | |
| D17S136E | |
| MGC17164 | |
| small inducible cytokine A5 | |
| SIS-delta | |
| beta-chemokine RANTES | |
| T-cell specific protein p288 | |
| T-cell specific RANTES protein | |
| small inducible cytokine A5 (RANTES) | |
| small inducible cytokine subfamily A (Cys-Cys), member 5 | |
| regulated upon activation, normally T-expressed, and presumably secreted | |
| MuRantes | |
| chemokine (C-C motif) ligand 5 | |
| OTTMUSP00000000943 | |
| chemokine (C-C motif) ligand V | |
| SY05 | |
| T cell-specific protein P228 | |
| beta-chemokine RANTES precursor | |
| Ccl5 | |
| monocyte chemoattractant cytokine RANTES | |
| SY05_HUMAN | |
| small inducible cytokine subfamily A (Cys-Cys), member V | |
| Small inducible cytokine A5 precursor | |
| TCP228s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 187011 |
|---|
| Swiss-Prot Accession | P13501 |
|---|---|
| Q9UBL2 | |
| P30882 | |
| Q5XZF2 | |
| Q6PED1 | |
| P50231 |
| Unigene ID | Hs.514821 |
|---|---|
| Mm.284248 | |
| Rn.8019 |
| KEGG ID | hsa:6352 |
|---|---|
| mmu:20304 | |
| rno:81780 |
| Swiss-Prot ID | CCL5_HUMAN |
|---|---|
| CCL5_MOUSE | |
| Q5XZF2_MOUSE | |
| Q6PED1_RAT |
| Cell Localization | Extracellular |
|---|
| GO ID | 0042056 |
|---|---|
| 0008009 | |
| 0004871 | |
| 0007155 | |
| 0006928 | |
| 0007267 | |
| 0006874 | |
| 0006968 | |
| 0006935 | |
| 0006887 | |
| 0006955 | |
| 0006954 | |
| 0045071 | |
| 0006979 | |
| 0034612 | |
| 0009615 | |
| 0007165 | |
| 0005737 | |
| 0005576 | |
| 0005615 | |
| 0005125 | |
| 0034097 | |
| 0048247 | |
| 0045672 | |
| 0005625 |
| IPI ID | IPI00009309 |
|---|---|
| IPI00382025 | |
| IPI00196447 | |
| IPI00555192 |
| Mouse chromosome position | 11 47.4 cM |
|---|
| Homologene ID | 2244 |
|---|
| MGI ID | 98262 |
|---|
| Rat chromosome position | 10q26 |
|---|
| RGD ID | 69069 |
|---|