| URN | urn:agi-llid:707 |
|---|---|
| Connectivity | 722 |
| Name | PTEN |
| Description | phosphatase and tensin homolog |
| Notes | This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq] |
| Pathway | PPARD Targets |
|---|---|
| PPARG Targets | |
| VDR Targets |
| Ariadne Ontology | Tumor suppressors |
|---|---|
| PTEN |
| GO Molecular Function | protein binding |
|---|---|
| lipid binding | |
| magnesium ion binding | |
| PDZ domain binding | |
| platelet-derived growth factor receptor binding | |
| hydrolase activity | |
| phosphatase activity | |
| inositol or phosphatidylinositol phosphatase activity | |
| phosphatidylinositol-3-phosphatase activity | |
| inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | |
| phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | |
| phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | |
| protein tyrosine phosphatase activity | |
| protein serine-threonine phosphatase activity | |
| protein tyrosine-serine-threonine phosphatase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| mitochondrion | |
| cytosol | |
| nucleus |
| GO Biological Process | angiogenesis |
|---|---|
| negative regulation of focal adhesion formation | |
| negative regulation of cell cycle | |
| negative regulation of cell proliferation | |
| negative regulation of protein kinase B signaling cascade | |
| negative regulation of apoptosis | |
| negative regulation of cell migration | |
| negative regulation of phagocytosis | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| regulation of cyclin-dependent protein kinase activity | |
| platelet-derived growth factor receptor signaling pathway | |
| regulation of protein stability | |
| cell cycle | |
| cell migration | |
| endothelial cell migration | |
| neuron projection development | |
| inositol phosphate dephosphorylation | |
| phosphoinositide dephosphorylation | |
| protein amino acid dephosphorylation | |
| aging | |
| heart development | |
| cardiac muscle tissue development | |
| central nervous system development | |
| lipid metabolic process | |
| memory | |
| response to drug | |
| response to organic substance | |
| response to inorganic substance | |
| response to nutrient | |
| response to estradiol stimulus | |
| response to arsenic | |
| response to zinc ion | |
| response to ethanol | |
| response to organic cyclic substance | |
| response to ATP | |
| response to glucose stimulus |
| Group | Tumor suppressors |
|---|---|
| PTEN | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| nucleus | |
| protein binding | |
| lipid binding | |
| magnesium ion binding | |
| PDZ domain binding | |
| platelet-derived growth factor receptor binding | |
| hydrolase activity | |
| phosphatase activity | |
| inositol or phosphatidylinositol phosphatase activity | |
| phosphatidylinositol-3-phosphatase activity | |
| inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | |
| phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | |
| phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | |
| protein tyrosine phosphatase activity | |
| protein serine-threonine phosphatase activity | |
| protein tyrosine-serine-threonine phosphatase activity | |
| angiogenesis | |
| negative regulation of focal adhesion formation | |
| negative regulation of cell cycle | |
| negative regulation of cell proliferation | |
| negative regulation of protein kinase B signaling cascade | |
| negative regulation of apoptosis | |
| negative regulation of cell migration | |
| negative regulation of phagocytosis | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| regulation of cyclin-dependent protein kinase activity | |
| platelet-derived growth factor receptor signaling pathway | |
| regulation of protein stability | |
| cell cycle | |
| cell migration | |
| endothelial cell migration | |
| neuron projection development | |
| inositol phosphate dephosphorylation | |
| phosphoinositide dephosphorylation | |
| protein amino acid dephosphorylation | |
| aging | |
| heart development | |
| cardiac muscle tissue development | |
| central nervous system development | |
| lipid metabolic process | |
| memory | |
| response to drug | |
| response to organic substance | |
| response to inorganic substance | |
| response to nutrient | |
| response to estradiol stimulus | |
| response to arsenic | |
| response to zinc ion | |
| response to ethanol | |
| response to organic cyclic substance | |
| response to ATP | |
| response to glucose stimulus |
| Hugo ID | 9588 |
|---|
| Human chromosome position | 10q23.3 |
|---|
| LocusLink ID | 707 |
|---|---|
| 5728 | |
| 19211 | |
| 50557 |
| Alias | BZS |
|---|---|
| MHAM | |
| TEP1 | |
| MMAC1 | |
| PTEN1 | |
| 10q23del | |
| MGC11227 | |
| phosphatase and tensin homolog | |
| OTTHUMP00000020032 | |
| mutated in multiple advanced cancers 1 | |
| MMAC1 phosphatase and tensin homolog deleted on chromosome 10 | |
| AI463227 | |
| 2310035O07Rik | |
| A130070J02Rik | |
| OTTMUSP00000023423 | |
| Mmac | |
| protein tyrosine phosphatase and tensin-like protein | |
| phosphatase and tensin homolog deleted on chromosome ten | |
| Bannayan-Zonana syndrome gene | |
| multiple hamartoma protein | |
| MMAC I | |
| phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | |
| RIKEN cDNA 2310035O07 gene | |
| Mutated in multiple advanced cancers 1 | |
| Protein-tyrosine phosphatase PTEN | |
| multiple hamartoma gene | |
| Mutated in multiple advanced cancers I | |
| PTEN | |
| PTEN I | |
| TEP I | |
| Bannayan-Zonana syndrome protein | |
| tensin homolog | |
| Chromosome 10q23 deletion syndrome | |
| multiple hamartoma (Cowden syndrome) gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601728 |
|---|---|
| 153480 | |
| 612242 | |
| 158350 | |
| 174900 | |
| 605309 | |
| 607174 | |
| 137800 | |
| 176807 | |
| 176920 | |
| 188470 | |
| 276950 |
| Swiss-Prot Accession | B2R904 |
|---|---|
| P60484 | |
| O08586 | |
| Q3UFB0 | |
| Q3UUN5 | |
| Q3UUT8 | |
| Q8BSR7 | |
| O54857 | |
| Q812B9 |
| Unigene ID | Hs.500466 |
|---|---|
| Mm.245395 | |
| Rn.22158 |
| KEGG ID | hsa:5728 |
|---|---|
| mmu:19211 | |
| rno:50557 |
| EC Number | 3.1.3.16 |
|---|---|
| 3.1.3.48 | |
| 3.1.3.67 |
| Swiss-Prot ID | PTEN_HUMAN |
|---|---|
| PTEN_MOUSE | |
| B2R904_HUMAN | |
| O54857_RAT |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0030165 |
|---|---|
| 0016787 | |
| 0051717 | |
| 0008289 | |
| 0000287 | |
| 0016314 | |
| 0051800 | |
| 0004438 | |
| 0005161 | |
| 0005515 | |
| 0004722 | |
| 0004725 | |
| 0008138 | |
| 0001525 | |
| 0048738 | |
| 0007417 | |
| 0043542 | |
| 0006917 | |
| 0046855 | |
| 0006629 | |
| 0043066 | |
| 0045786 | |
| 0030336 | |
| 0008285 | |
| 0051895 | |
| 0051898 | |
| 0031175 | |
| 0046856 | |
| 0048008 | |
| 0006470 | |
| 0000079 | |
| 0031647 | |
| 0005737 | |
| 0005829 | |
| 0005634 | |
| 0007049 | |
| 0016477 | |
| 0007507 | |
| 0004437 | |
| 0016791 | |
| 0007568 | |
| 0007613 | |
| 0050765 | |
| 0043065 | |
| 0033198 | |
| 0046685 | |
| 0042493 | |
| 0032355 | |
| 0045471 | |
| 0009749 | |
| 0010035 | |
| 0007584 | |
| 0014070 | |
| 0010033 | |
| 0010043 | |
| 0005739 |
| IPI ID | IPI00012587 |
|---|---|
| IPI00114410 | |
| IPI00652977 | |
| IPI00199035 |
| Mouse chromosome position | 19 24.5 cM |
|---|
| Homologene ID | 265 |
|---|
| MGI ID | 109583 |
|---|
| RGD ID | 61995 |
|---|