| URN | urn:agi-llid:3383 |
|---|---|
| Connectivity | 1293 |
| Name | ICAM1 |
| Description | intercellular adhesion molecule 1 |
| Notes | This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq] |
| Pathway | MacrophageR -> CEBPB/NF-kB signaling |
|---|---|
| ICAM1 -> AP-1/CREB/ELK-SRF signaling | |
| PPARA Targets | |
| PPARD Targets | |
| PPARG Targets | |
| RORA Targets | |
| FXR Targets | |
| GR Targets |
| Ariadne Ontology | ECM-Cell adhesion proteins |
|---|
| GO Molecular Function | protein binding |
|---|---|
| integrin binding | |
| transmembrane receptor activity |
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| external side of plasma membrane | |
| cytoplasm | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| immunological synapse | |
| extracellular space |
| GO Biological Process | cell adhesion |
|---|---|
| adhesion to symbiont | |
| cell-cell adhesion | |
| regulation of cell adhesion | |
| cell adhesion mediated by integrin | |
| leukocyte adhesion | |
| heterophilic cell adhesion | |
| positive regulation of cellular extravasation | |
| positive regulation of nitric oxide biosynthetic process | |
| regulation of leukocyte mediated cytotoxicity | |
| positive regulation of NF-kappaB transcription factor activity | |
| T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell | |
| leukocyte migration | |
| membrane to membrane docking | |
| T cell antigen processing and presentation | |
| virion attachment, binding of host cell surface receptor | |
| interspecies interaction between organisms |
| Group | ECM-Cell adhesion proteins |
|---|---|
| cell surface | |
| membrane | |
| external side of plasma membrane | |
| cytoplasm | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| immunological synapse | |
| extracellular space | |
| protein binding | |
| integrin binding | |
| transmembrane receptor activity | |
| cell adhesion | |
| adhesion to symbiont | |
| cell-cell adhesion | |
| regulation of cell adhesion | |
| cell adhesion mediated by integrin | |
| leukocyte adhesion | |
| heterophilic cell adhesion | |
| positive regulation of cellular extravasation | |
| positive regulation of nitric oxide biosynthetic process | |
| regulation of leukocyte mediated cytotoxicity | |
| positive regulation of NF-kappaB transcription factor activity | |
| T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell | |
| leukocyte migration | |
| membrane to membrane docking | |
| T cell antigen processing and presentation | |
| virion attachment, binding of host cell surface receptor | |
| interspecies interaction between organisms |
| Hugo ID | 5344 |
|---|
| Human chromosome position | 19p13.3-p13.2 |
|---|
| LocusLink ID | 3383 |
|---|---|
| 15894 | |
| 25464 |
| Alias | BB2 |
|---|---|
| CD54 | |
| P3.58 | |
| intercellular adhesion molecule 1 | |
| human rhinovirus receptor | |
| cell surface glycoprotein P3.58 | |
| intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | |
| Ly-47 | |
| Icam-1 | |
| MALA-2 | |
| MGC6195 | |
| intercellular adhesion molecule | |
| ICAM | |
| Icam1 | |
| Intercellular adhesion molecule-1 | |
| Major group rhinovirus receptor | |
| cell surface glycoprotein P3 | |
| Intercellular adhesion molecule I | |
| (sICAM)-1 | |
| (sICAM)-I | |
| Icam I | |
| MALA IIs | |
| intercellular adhesion molecule 1 (CD54), human rhinovirus receptors | |
| Major group rhinovirus receptors | |
| soluble intercellular adhesion molecule I | |
| soluble intercellular adhesion molecule 1 | |
| soluble intercellular adhesion molecule sICAM-1 | |
| soluble intercellular adhesion molecule sICAM-I | |
| MALA II | |
| LOC125951 | |
| (sICAM)-1s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 147840 |
|---|---|
| 248310 | |
| 611162 |
| Swiss-Prot Accession | B2R6M3 |
|---|---|
| P05362 | |
| O00177 | |
| Q14601 | |
| Q15463 | |
| Q5NKV8 | |
| Q99930 | |
| P13597 | |
| Q3U8M7 | |
| Q3TB10 | |
| Q3TB21 | |
| Q3THH5 | |
| Q3U7Q9 | |
| Q3U7T2 | |
| Q3UAU5 | |
| Q3UDC5 | |
| Q3UDJ5 | |
| Q3UE52 | |
| Q4FK06 | |
| Q922B3 | |
| Q00238 |
| Unigene ID | Hs.643447 |
|---|---|
| Mm.435508 | |
| Rn.12 |
| KEGG ID | hsa:3383 |
|---|---|
| mmu:15894 | |
| rno:25464 |
| Swiss-Prot ID | ICAM1_HUMAN |
|---|---|
| ICAM1_MOUSE | |
| ICAM1_RAT | |
| B2R6M3_HUMAN | |
| Q3U8M7_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005178 |
|---|---|
| 0005515 | |
| 0004888 | |
| 0002291 | |
| 0002457 | |
| 0051856 | |
| 0033627 | |
| 0007157 | |
| 0044419 | |
| 0007159 | |
| 0050900 | |
| 0022614 | |
| 0002693 | |
| 0030155 | |
| 0001910 | |
| 0046813 | |
| 0005737 | |
| 0009897 | |
| 0005615 | |
| 0005887 | |
| 0005886 | |
| 0007155 | |
| 0016337 | |
| 0001772 | |
| 0016021 | |
| 0016020 | |
| 0051092 | |
| 0045429 | |
| 0009986 |
| IPI ID | IPI00008494 |
|---|---|
| IPI00910734 | |
| IPI00816354 | |
| IPI00816809 | |
| IPI00642425 | |
| IPI00122973 | |
| IPI00230702 | |
| IPI00197164 | |
| IPI00778187 |
| Mouse chromosome position | 9 7.0 cM |
|---|
| Homologene ID | 168 |
|---|
| MGI ID | 96392 |
|---|
| Rat chromosome position | 8q13 |
|---|
| RGD ID | 2857 |
|---|