| URN | urn:agi-llid:7422 |
|---|---|
| Connectivity | 2385 |
| Name | VEGFA |
| Description | vascular endothelial growth factor A |
| Notes | This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq] |
| Pathway | VEGFR -> CTNNB signaling |
|---|---|
| VEGFR -> NFATC signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| VEGFR -> CTNND signaling | |
| VEGFR -> STAT signaling | |
| Common Regulators | |
| TRA Targets | |
| RARA Targets | |
| PPARA Targets | |
| PPARD Targets | |
| PPARG Targets | |
| RORG Targets | |
| LXRA Targets | |
| LXRB Targets | |
| ERA Pathway | |
| ERB Targets | |
| PGR Targets | |
| NR5A1 Targets |
| Ariadne Ontology | GF |
|---|
| GO Molecular Function | protein binding |
|---|---|
| cell surface binding | |
| extracellular matrix binding | |
| heparin binding | |
| fibronectin binding | |
| protein homodimerization activity | |
| vascular endothelial growth factor receptor binding | |
| growth factor activity | |
| cytokine activity | |
| platelet-derived growth factor receptor binding | |
| vascular endothelial growth factor receptor 1 binding | |
| vascular endothelial growth factor receptor 2 binding |
| GO Cellular Component | extracellular region |
|---|---|
| cell surface | |
| membrane | |
| cytoplasm | |
| platelet alpha granule lumen | |
| plasma membrane | |
| extracellular space | |
| proteinaceous extracellular matrix | |
| basement membrane | |
| membrane-bounded vesicle |
| GO Biological Process | angiogenesis |
|---|---|
| patterning of blood vessels | |
| negative regulation of programmed cell death | |
| negative regulation of apoptosis | |
| anti-apoptosis | |
| negative regulation of bone resorption | |
| positive regulation of cell proliferation | |
| positive regulation of signal transduction | |
| positive regulation of vascular endothelial growth factor receptor signaling pathway | |
| positive regulation of leukocyte migration | |
| positive regulation of blood vessel endothelial cell migration | |
| positive regulation of mesenchymal cell proliferation | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of endothelial cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of transcription from RNA polymerase II promoter | |
| induction of positive chemotaxis | |
| regulation of cell shape | |
| mRNA stabilization | |
| platelet-derived growth factor receptor signaling pathway | |
| vascular endothelial growth factor receptor signaling pathway | |
| surfactant homeostasis | |
| primitive erythrocyte differentiation | |
| positive regulation of vascular permeability | |
| cell proliferation | |
| cell migration | |
| cell maturation | |
| cell differentiation | |
| eye photoreceptor cell development | |
| vasculogenesis | |
| epithelial cell differentiation | |
| multicellular organismal development | |
| alveolus development | |
| branching morphogenesis of a tube | |
| blood vessel morphogenesis | |
| blood vessel remodeling | |
| camera-type eye morphogenesis | |
| lung development | |
| ovarian follicle development | |
| mesoderm development | |
| blood vessel development | |
| nervous system development | |
| T-helper 1 type immune response | |
| response to hypoxia |
| Group | GF |
|---|---|
| extracellular region | |
| cell surface | |
| membrane | |
| cytoplasm | |
| platelet alpha granule lumen | |
| plasma membrane | |
| extracellular space | |
| proteinaceous extracellular matrix | |
| basement membrane | |
| membrane-bounded vesicle | |
| protein binding | |
| cell surface binding | |
| extracellular matrix binding | |
| heparin binding | |
| fibronectin binding | |
| protein homodimerization activity | |
| vascular endothelial growth factor receptor binding | |
| growth factor activity | |
| cytokine activity | |
| platelet-derived growth factor receptor binding | |
| vascular endothelial growth factor receptor 1 binding | |
| vascular endothelial growth factor receptor 2 binding | |
| angiogenesis | |
| patterning of blood vessels | |
| negative regulation of programmed cell death | |
| negative regulation of apoptosis | |
| anti-apoptosis | |
| negative regulation of bone resorption | |
| positive regulation of cell proliferation | |
| positive regulation of signal transduction | |
| positive regulation of vascular endothelial growth factor receptor signaling pathway | |
| positive regulation of leukocyte migration | |
| positive regulation of blood vessel endothelial cell migration | |
| positive regulation of mesenchymal cell proliferation | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of endothelial cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of transcription from RNA polymerase II promoter | |
| induction of positive chemotaxis | |
| regulation of cell shape | |
| mRNA stabilization | |
| platelet-derived growth factor receptor signaling pathway | |
| vascular endothelial growth factor receptor signaling pathway | |
| surfactant homeostasis | |
| primitive erythrocyte differentiation | |
| positive regulation of vascular permeability | |
| cell proliferation | |
| cell migration | |
| cell maturation | |
| cell differentiation | |
| eye photoreceptor cell development | |
| vasculogenesis | |
| epithelial cell differentiation | |
| multicellular organismal development | |
| alveolus development | |
| branching morphogenesis of a tube | |
| blood vessel morphogenesis | |
| blood vessel remodeling | |
| camera-type eye morphogenesis | |
| lung development | |
| ovarian follicle development | |
| mesoderm development | |
| blood vessel development | |
| nervous system development | |
| T-helper 1 type immune response | |
| response to hypoxia |
| Hugo ID | 12680 |
|---|
| Human chromosome position | 6p12 |
|---|
| LocusLink ID | 7422 |
|---|---|
| 22339 | |
| 83785 |
| Alias | VPF |
|---|---|
| VEGF | |
| MVCD1 | |
| VEGF-A | |
| MGC70609 | |
| RP1-261G23.1 | |
| vascular endothelial growth factor A | |
| vascular permeability factor | |
| vascular endothelial growth factor isoform VEGF165 | |
| Vegf120 | |
| Vegf164 | |
| Vegf188 | |
| OTTMUSP00000017463 | |
| OTTMUSP00000017464 | |
| OTTMUSP00000022243 | |
| VEGF121 | |
| VEGF165 | |
| Vascular endothelial growth factor precursor | |
| GNB:37659 | |
| vascular endothelial growth factor variant | |
| Vascular permeability factor | |
| VEGFA | |
| Vascular endothelial growth factor 121 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 192240 |
|---|---|
| 125853 | |
| 603933 |
| Swiss-Prot Accession | P15692 |
|---|---|
| Q59FH5 | |
| Q6WZM0 | |
| Q71S09 | |
| Q96FD9 | |
| Q9UNS8 | |
| Q00731 | |
| A0FKR4 | |
| Q5UD54 | |
| Q6YLN3 | |
| Q80UA0 | |
| B5DEK7 | |
| P16612 | |
| Q541S7 | |
| O88911 | |
| Q63672 | |
| Q64FZ6 | |
| Q78EG9 | |
| Q91V21 | |
| Q91Y66 | |
| Q91Y68 | |
| Q91ZE2 |
| Unigene ID | Hs.73793 |
|---|---|
| Mm.282184 | |
| Mm.477156 | |
| Rn.1923 |
| KEGG ID | hsa:7422 |
|---|---|
| mmu:22339 |
| Swiss-Prot ID | VEGFA_HUMAN |
|---|---|
| VEGFA_MOUSE | |
| VEGFA_RAT | |
| B5DEK7_RAT | |
| Q541S7_RAT |
| Cell Localization | Extracellular |
|---|
| GO ID | 0043498 |
|---|---|
| 0005125 | |
| 0050840 | |
| 0001968 | |
| 0008083 | |
| 0008201 | |
| 0005161 | |
| 0042803 | |
| 0043183 | |
| 0043184 | |
| 0001525 | |
| 0050930 | |
| 0007275 | |
| 0043066 | |
| 0007399 | |
| 0048008 | |
| 0043536 | |
| 0001938 | |
| 0002687 | |
| 0030949 | |
| 0008360 | |
| 0001666 | |
| 0001570 | |
| 0009986 | |
| 0005576 | |
| 0005615 | |
| 0016020 | |
| 0031093 | |
| 0005578 | |
| 0005515 | |
| 0006916 | |
| 0001568 | |
| 0048514 | |
| 0048754 | |
| 0048593 | |
| 0030154 | |
| 0048469 | |
| 0016477 | |
| 0008283 | |
| 0030855 | |
| 0042462 | |
| 0030324 | |
| 0007498 | |
| 0001541 | |
| 0001569 | |
| 0008284 | |
| 0050679 | |
| 0002053 | |
| 0060319 | |
| 0043129 | |
| 0048010 | |
| 0005737 | |
| 0005886 | |
| 0005172 | |
| 0042088 | |
| 0048286 | |
| 0001974 | |
| 0048255 | |
| 0045779 | |
| 0043069 | |
| 0009967 | |
| 0048661 | |
| 0045944 | |
| 0043117 | |
| 0005604 | |
| 0031988 |
| IPI ID | IPI00915448 |
|---|---|
| IPI00852889 | |
| IPI00216555 | |
| IPI00872936 | |
| IPI00607893 | |
| IPI00555908 | |
| IPI00793077 | |
| IPI00436015 | |
| IPI00012567 | |
| IPI00216554 | |
| IPI00374772 | |
| IPI00064652 | |
| IPI00607783 | |
| IPI00216553 | |
| IPI00829762 | |
| IPI00656297 | |
| IPI00475372 | |
| IPI00467967 | |
| IPI00223442 | |
| IPI00877296 | |
| IPI00877306 | |
| IPI00877273 | |
| IPI00402915 | |
| IPI00831263 | |
| IPI00830961 | |
| IPI00231977 | |
| IPI00214186 | |
| IPI00199066 | |
| IPI00209785 | |
| IPI00327982 | |
| IPI00877356 | |
| IPI00214604 |
| Mouse chromosome position | 17 24.2 cM |
|---|
| Homologene ID | 2534 |
|---|
| MGI ID | 103178 |
|---|
| Rat chromosome position | 9q12 |
|---|
| RGD ID | 619991 |
|---|