| URN | urn:agi-llid:2321 |
|---|---|
| Connectivity | 485 |
| Name | FLT1 |
| Description | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) |
| Notes | Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM] |
| Pathway | VEGFR -> CTNNB signaling |
|---|---|
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| PPARD Targets | |
| PPARG Targets | |
| ERA Pathway |
| Ariadne Ontology | GFR |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| ATP binding | |
| growth factor binding | |
| identical protein binding | |
| transferase activity | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| receptor signaling protein tyrosine kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| vascular endothelial growth factor receptor activity | |
| receptor activity |
| GO Cellular Component | extracellular region |
|---|---|
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| extracellular space |
| GO Biological Process | angiogenesis |
|---|---|
| patterning of blood vessels | |
| positive regulation of cell proliferation | |
| positive regulation of vascular endothelial growth factor receptor signaling pathway | |
| positive regulation of cell migration | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of fibroblast proliferation | |
| activation of MAPKK activity | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| vascular endothelial growth factor receptor signaling pathway | |
| intracellular receptor-mediated signaling pathway | |
| regulation of smooth muscle contraction | |
| cell migration | |
| cell differentiation | |
| protein amino acid phosphorylation | |
| multicellular organismal development | |
| female pregnancy | |
| response to hypoxia |
| Group | GFR |
|---|---|
| extracellular region | |
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| extracellular space | |
| nucleotide binding | |
| ATP binding | |
| growth factor binding | |
| identical protein binding | |
| transferase activity | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| receptor signaling protein tyrosine kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| vascular endothelial growth factor receptor activity | |
| receptor activity | |
| angiogenesis | |
| patterning of blood vessels | |
| positive regulation of cell proliferation | |
| positive regulation of vascular endothelial growth factor receptor signaling pathway | |
| positive regulation of cell migration | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of fibroblast proliferation | |
| activation of MAPKK activity | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| vascular endothelial growth factor receptor signaling pathway | |
| intracellular receptor-mediated signaling pathway | |
| regulation of smooth muscle contraction | |
| cell migration | |
| cell differentiation | |
| protein amino acid phosphorylation | |
| multicellular organismal development | |
| female pregnancy | |
| response to hypoxia |
| Hugo ID | 3763 |
|---|
| Human chromosome position | 13q12 |
|---|
| LocusLink ID | 2321 |
|---|---|
| 14254 | |
| 54251 |
| Alias | FLT |
|---|---|
| VEGFR1 | |
| FMS-related tyrosine kinase 1 | |
| Flt-1 | |
| sFlt1 | |
| VEGFR-1 | |
| AI323757 | |
| OTTMUSP00000023727 | |
| vascular permeability factor receptor | |
| vascular endothelial growth factor receptor | |
| vascular endothelial growth factor receptor-1 | |
| FMS-like tyrosine kinase 1 | |
| Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | |
| Flt1 | |
| Tyrosine-protein kinase receptor FLT | |
| Vascular endothelial growth factor receptor 1 | |
| VEGF receptor | |
| VGR1_HUMAN | |
| FMS-like tyrosine kinase I | |
| fms-related tyrosine kinase I | |
| VEGF receptor I | |
| Vascular endothelial growth factor receptor I | |
| VEGF-R1 | |
| Flt I | |
| sFlt I | |
| VEGFR I | |
| Vascular endothelial growth factor precursor receptors | |
| VEGF receptor 1 | |
| Tyrosine- protein kinase FRT | |
| Vascular permeability factor receptors | |
| VEGF receptors | |
| FRT | |
| soluble VEGF receptor 1-14 | |
| soluble VEGFR1 variant 2 | |
| soluble VEGFR1 variant 21 | |
| vascular endothelial growth factor/vascular permeability factor receptor | |
| VEGFR-1s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 165070 |
|---|
| Swiss-Prot Accession | B0LPF1 |
|---|---|
| P17948 | |
| Q16332 | |
| Q16333 | |
| Q59GQ9 | |
| O55095 | |
| P35969 | |
| Q3TJC1 | |
| Q5GRG7 | |
| Q78ZF4 | |
| Q8K1H4 | |
| Q9CSC8 | |
| Q9CW58 | |
| Q9DAV2 | |
| P53767 | |
| Q9JJ08 |
| Unigene ID | Hs.654360 |
|---|---|
| Mm.389712 | |
| Rn.10239 |
| KEGG ID | rno:54251 |
|---|
| EC Number | 2.7.10.1 |
|---|
| Swiss-Prot ID | VGFR1_HUMAN |
|---|---|
| VGFR1_RAT | |
| B0LPF1_HUMAN |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0005524 |
|---|---|
| 0019838 | |
| 0042802 | |
| 0000166 | |
| 0004872 | |
| 0016740 | |
| 0005021 | |
| 0030154 | |
| 0016477 | |
| 0007565 | |
| 0007275 | |
| 0001569 | |
| 0008284 | |
| 0030949 | |
| 0006468 | |
| 0007169 | |
| 0005576 | |
| 0005615 | |
| 0005887 | |
| 0005886 | |
| 0016301 | |
| 0004672 | |
| 0004713 | |
| 0004714 | |
| 0001525 | |
| 0048010 | |
| 0016021 | |
| 0016020 | |
| 0004716 | |
| 0000186 | |
| 0030522 | |
| 0030335 | |
| 0048146 | |
| 0048661 | |
| 0006940 | |
| 0001666 |
| IPI ID | IPI00018335 |
|---|---|
| IPI00216043 | |
| IPI00815971 | |
| IPI00816497 | |
| IPI00124497 | |
| IPI00551339 | |
| IPI00119072 | |
| IPI00212864 | |
| IPI00779044 |
| Mouse chromosome position | 5 82.0 cM |
|---|
| Homologene ID | 20463 |
|---|
| MGI ID | 95558 |
|---|
| Rat chromosome position | 12p11 |
|---|
| RGD ID | 2621 |
|---|