| URN | urn:agi-llid:7157 |
|---|---|
| Connectivity | 2936 |
| Name | TP53 |
| Description | tumor protein p53 |
| Notes | This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq] |
| Pathway | CCR5 -> TP53 signaling |
|---|---|
| SomatostatinR -> ATF1/TP53 signaling | |
| AngiotensinR -> CREB/ELK-SRF/TP53 signaling | |
| Sialophorin -> CTNNB/MYC/TP53 signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| TGFBR -> ATF/GADD/MAX/TP53 signaling | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| Apoptosis | |
| Common Regulators | |
| PPARG Targets | |
| ERA Pathway |
| Ariadne Ontology | Tumor suppressors |
|---|---|
| p53 |
| GO Molecular Function | protein binding |
|---|---|
| chromatin binding | |
| metal ion binding | |
| copper ion binding | |
| zinc ion binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription factor activity | |
| DNA strand annealing activity | |
| ATP binding | |
| protein N-terminus binding | |
| chaperone binding | |
| enzyme binding | |
| protein heterodimerization activity | |
| nuclease activity | |
| RNA polymerase II transcription factor activity |
| GO Cellular Component | insoluble fraction |
|---|---|
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| endoplasmic reticulum | |
| nucleus | |
| nucleoplasm | |
| nuclear matrix | |
| nucleolus | |
| transcription factor complex | |
| PML body | |
| replication fork | |
| chromatin |
| GO Biological Process | protein complex assembly |
|---|---|
| protein tetramerization | |
| negative regulation of cell cycle | |
| negative regulation of cell proliferation | |
| negative regulation of cell growth | |
| negative regulation of apoptosis | |
| negative regulation of neuroblast proliferation | |
| negative regulation of smooth muscle cell proliferation | |
| negative regulation of fibroblast proliferation | |
| negative regulation of DNA replication | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of cell cycle | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| induction of apoptosis by intracellular signals | |
| DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis | |
| positive regulation of neuron apoptosis | |
| positive regulation of leukocyte migration | |
| positive regulation of transcription | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of specific transcription from RNA polymerase II promoter | |
| regulation of cell cycle | |
| regulation of cell proliferation | |
| G1 DNA damage checkpoint | |
| regulation of apoptosis | |
| regulation of neuron apoptosis | |
| activation of caspase activity by cytochrome c | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| DNA damage response, signal transduction by p53 class mediator | |
| ER overload response | |
| regulation of mitochondrial membrane permeability | |
| regulation of intracellular pH | |
| negative regulation of helicase activity | |
| cell aging | |
| cell cycle | |
| cell proliferation | |
| T cell proliferation during immune response | |
| B cell lineage commitment | |
| T cell differentiation in the thymus | |
| T cell lineage commitment | |
| cellular response to glucose starvation | |
| cell cycle arrest | |
| apoptosis | |
| release of cytochrome c from mitochondria | |
| chromosome organization | |
| cell differentiation | |
| protein import into nucleus, translocation | |
| transcription | |
| rRNA transcription | |
| RNA-protein covalent cross-linking | |
| base-excision repair | |
| nucleotide-excision repair | |
| double-strand break repair | |
| cellular response to UV | |
| multicellular organismal development | |
| aging | |
| gastrulation | |
| central nervous system development | |
| embryonic development ending in birth or egg hatching | |
| in utero embryonic development | |
| protein localization | |
| interspecies interaction between organisms | |
| response to chemical stimulus | |
| response to salt stress | |
| response to gamma radiation | |
| response to X-ray | |
| response to UV | |
| response to tumor cell | |
| response to drug | |
| response to inorganic substance | |
| response to cytokine stimulus | |
| response to oxidative stress | |
| response to amino acid stimulus | |
| response to metal ion | |
| response to vitamin B3 | |
| response to retinoic acid | |
| response to organic nitrogen | |
| response to organic cyclic substance | |
| response to caffeine | |
| response to hyperoxia | |
| wound healing | |
| response to DNA damage stimulus |
| Group | Tumor suppressors |
|---|---|
| p53 | |
| insoluble fraction | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| endoplasmic reticulum | |
| nucleus | |
| nucleoplasm | |
| nuclear matrix | |
| nucleolus | |
| transcription factor complex | |
| PML body | |
| replication fork | |
| chromatin | |
| protein binding | |
| chromatin binding | |
| metal ion binding | |
| copper ion binding | |
| zinc ion binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription factor activity | |
| DNA strand annealing activity | |
| ATP binding | |
| protein N-terminus binding | |
| chaperone binding | |
| enzyme binding | |
| protein heterodimerization activity | |
| nuclease activity | |
| RNA polymerase II transcription factor activity | |
| protein complex assembly | |
| protein tetramerization | |
| negative regulation of cell cycle | |
| negative regulation of cell proliferation | |
| negative regulation of cell growth | |
| negative regulation of apoptosis | |
| negative regulation of neuroblast proliferation | |
| negative regulation of smooth muscle cell proliferation | |
| negative regulation of fibroblast proliferation | |
| negative regulation of DNA replication | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of cell cycle | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| induction of apoptosis by intracellular signals | |
| DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis | |
| positive regulation of neuron apoptosis | |
| positive regulation of leukocyte migration | |
| positive regulation of transcription | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of specific transcription from RNA polymerase II promoter | |
| regulation of cell cycle | |
| regulation of cell proliferation | |
| G1 DNA damage checkpoint | |
| regulation of apoptosis | |
| regulation of neuron apoptosis | |
| activation of caspase activity by cytochrome c | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| DNA damage response, signal transduction by p53 class mediator | |
| ER overload response | |
| regulation of mitochondrial membrane permeability | |
| regulation of intracellular pH | |
| negative regulation of helicase activity | |
| cell aging | |
| cell cycle | |
| cell proliferation | |
| T cell proliferation during immune response | |
| B cell lineage commitment | |
| T cell differentiation in the thymus | |
| T cell lineage commitment | |
| cellular response to glucose starvation | |
| cell cycle arrest | |
| apoptosis | |
| release of cytochrome c from mitochondria | |
| chromosome organization | |
| cell differentiation | |
| protein import into nucleus, translocation | |
| transcription | |
| rRNA transcription | |
| RNA-protein covalent cross-linking | |
| base-excision repair | |
| nucleotide-excision repair | |
| double-strand break repair | |
| cellular response to UV | |
| multicellular organismal development | |
| aging | |
| gastrulation | |
| central nervous system development | |
| embryonic development ending in birth or egg hatching | |
| in utero embryonic development | |
| protein localization | |
| interspecies interaction between organisms | |
| response to chemical stimulus | |
| response to salt stress | |
| response to gamma radiation | |
| response to X-ray | |
| response to UV | |
| response to tumor cell | |
| response to drug | |
| response to inorganic substance | |
| response to cytokine stimulus | |
| response to oxidative stress | |
| response to amino acid stimulus | |
| response to metal ion | |
| response to vitamin B3 | |
| response to retinoic acid | |
| response to organic nitrogen | |
| response to organic cyclic substance | |
| response to caffeine | |
| response to hyperoxia | |
| wound healing | |
| response to DNA damage stimulus |
| Hugo ID | 11998 |
|---|
| Human chromosome position | 17p13.1 |
|---|
| LocusLink ID | 7157 |
|---|---|
| 22059 | |
| 24842 |
| Alias | p53 |
|---|---|
| LFS1 | |
| TRP53 | |
| FLJ92943 | |
| tumor protein p53 | |
| p53 antigen | |
| phosphoprotein p53 | |
| p53 tumor suppressor | |
| p53 transformation suppressor | |
| transformation-related protein 53 | |
| bbl | |
| bfy | |
| bhy | |
| RP23-56I20.1 | |
| transformation related protein 53 | |
| tumor supressor p53 | |
| p53 cellular tumor antigen | |
| MGC112612 | |
| tumor protein p53 (Li-Fraumeni syndrome) | |
| Tumor suppressor p53 | |
| cys51stop | |
| Cellular tumor antigen p53 | |
| TP53 | |
| p53 alternative splice isoform p35/HAS | |
| P53_HUMAN | |
| TRP53 gene | |
| TRP53 protein | |
| LOC146749 | |
| LOC201237 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 191170 |
|---|---|
| 202300 | |
| 114480 | |
| 260500 | |
| 114500 | |
| 114550 | |
| 151623 | |
| 161550 | |
| 259500 | |
| 260350 |
| Unigene ID | Hs.654481 |
|---|---|
| Mm.222 | |
| Rn.54443 |
| KEGG ID | mmu:22059 |
|---|---|
| rno:24842 |
| Swiss-Prot ID | P53_HUMAN |
|---|---|
| P53_MOUSE | |
| P53_RAT | |
| Q3LRW1_HUMAN | |
| Q3LRW2_HUMAN | |
| Q3LRW3_HUMAN | |
| Q3LRW4_HUMAN | |
| Q549C9_MOUSE | |
| Q80ZA1_MOUSE |
| Cell Localization | Nucleus |
|---|
| GO ID | 0005524 |
|---|---|
| 0000739 | |
| 0051087 | |
| 0003682 | |
| 0005507 | |
| 0019899 | |
| 0046872 | |
| 0004518 | |
| 0047485 | |
| 0046982 | |
| 0003700 | |
| 0008270 | |
| 0002326 | |
| 0042771 | |
| 0006983 | |
| 0031571 | |
| 0018144 | |
| 0033077 | |
| 0002360 | |
| 0002309 | |
| 0008635 | |
| 0006284 | |
| 0007569 | |
| 0007050 | |
| 0030154 | |
| 0008283 | |
| 0042149 | |
| 0007417 | |
| 0006302 | |
| 0009792 | |
| 0007369 | |
| 0001701 | |
| 0008629 | |
| 0044419 | |
| 0007275 | |
| 0008156 | |
| 0043066 | |
| 0045786 | |
| 0030308 | |
| 0048147 | |
| 0051097 | |
| 0007406 | |
| 0000122 | |
| 0006289 | |
| 0043525 | |
| 0010552 | |
| 0006461 | |
| 0000060 | |
| 0008104 | |
| 0051262 | |
| 0051453 | |
| 0046902 | |
| 0006355 | |
| 0001836 | |
| 0006974 | |
| 0009411 | |
| 0010165 | |
| 0042493 | |
| 0010332 | |
| 0002347 | |
| 0016605 | |
| 0005737 | |
| 0005829 | |
| 0005783 | |
| 0005626 | |
| 0005739 | |
| 0016363 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0005657 | |
| 0003677 | |
| 0005515 | |
| 0030330 | |
| 0006915 | |
| 0007049 | |
| 0034644 | |
| 0051276 | |
| 0006917 | |
| 0008285 | |
| 0043065 | |
| 0045941 | |
| 0045944 | |
| 0045893 | |
| 0009303 | |
| 0042981 | |
| 0051726 | |
| 0042127 | |
| 0043523 | |
| 0009651 | |
| 0006350 | |
| 0003702 | |
| 0043565 | |
| 0007568 | |
| 0048662 | |
| 0045787 | |
| 0002687 | |
| 0006357 | |
| 0043200 | |
| 0031000 | |
| 0042221 | |
| 0034097 | |
| 0055093 | |
| 0010035 | |
| 0010038 | |
| 0014070 | |
| 0010243 | |
| 0006979 | |
| 0032526 | |
| 0033552 | |
| 0042060 | |
| 0000785 | |
| 0005667 |
| IPI ID | IPI00025087 |
|---|---|
| IPI00895905 | |
| IPI00816804 | |
| IPI00902894 | |
| IPI00375319 | |
| IPI00654847 | |
| IPI00796188 | |
| IPI00894418 | |
| IPI00406306 | |
| IPI00648350 | |
| IPI00734784 | |
| IPI00190116 | |
| IPI00203524 | |
| IPI00189385 |
| Mouse chromosome position | 11 39.0 cM |
|---|
| Homologene ID | 460 |
|---|
| MGI ID | 98834 |
|---|
| Rat chromosome position | 10q24 |
|---|
| RGD ID | 3889 |
|---|