| URN | urn:agi-llid:4314 |
|---|---|
| Connectivity | 529 |
| Name | MMP3 |
| Description | matrix metallopeptidase 3 (stromelysin 1, progelatinase) |
| Notes | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq] |
| Pathway | PPARG Targets |
|---|---|
| NURR1 Targets | |
| AR Targets |
| Ariadne Ontology | ECM degradation |
|---|
| GO Molecular Function | metal ion binding |
|---|---|
| calcium ion binding | |
| zinc ion binding | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| metalloendopeptidase activity |
| GO Cellular Component | extracellular region |
|---|---|
| intracellular membrane-bounded organelle | |
| extracellular space | |
| proteinaceous extracellular matrix |
| GO Biological Process | metabolic process |
|---|---|
| proteolysis | |
| collagen catabolic process | |
| response to cytokine stimulus | |
| response to amino acid stimulus |
| Group | ECM degradation |
|---|---|
| extracellular region | |
| intracellular membrane-bounded organelle | |
| extracellular space | |
| proteinaceous extracellular matrix | |
| metal ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| metalloendopeptidase activity | |
| metabolic process | |
| proteolysis | |
| collagen catabolic process | |
| response to cytokine stimulus | |
| response to amino acid stimulus |
| Hugo ID | 7173 |
|---|
| Human chromosome position | 11q22.3 |
|---|
| LocusLink ID | 4314 |
|---|---|
| 17392 | |
| 171045 |
| Alias | SL-1 |
|---|---|
| STMY | |
| STR1 | |
| CHDS6 | |
| MMP-3 | |
| STMY1 | |
| MGC126102 | |
| MGC126103 | |
| MGC126104 | |
| matrix metalloproteinase 3 | |
| transin-1 | |
| progelatinase | |
| stromelysin 1 | |
| proteoglycanase | |
| matrix metalloproteinase 3 (stromelysin 1, progelatinase) | |
| SLN1 | |
| SLN-1 | |
| STR-1 | |
| matrix metallopeptidase 3 | |
| stromelysin-1 | |
| STMY I | |
| matrix metallopeptidase III | |
| matrix metalloproteinase 3 preproprotein | |
| Mmp3 | |
| progelatinases | |
| Transin I | |
| stromelysin I | |
| SLN I | |
| STR I | |
| SL I | |
| matrix metalloproteinase 3 (stromelysin 1) | |
| matrix metallopeptidase 3 (stromelysin 1, progelatinase) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 185250 |
|---|
| Swiss-Prot Accession | B2R8B8 |
|---|---|
| P08254 | |
| P28862 | |
| Q922W6 | |
| Q3UFJ0 | |
| Q6GXA4 | |
| P03957 |
| Unigene ID | Hs.375129 |
|---|---|
| Mm.4993 | |
| Rn.32086 |
| KEGG ID | mmu:17392 |
|---|---|
| rno:171045 |
| EC Number | 3.4.24.17 |
|---|
| Swiss-Prot ID | MMP3_HUMAN |
|---|---|
| MMP3_MOUSE | |
| MMP3_RAT | |
| B2R8B8_HUMAN | |
| Q922W6_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005509 |
|---|---|
| 0004222 | |
| 0008233 | |
| 0008270 | |
| 0030574 | |
| 0008152 | |
| 0006508 | |
| 0005576 | |
| 0005615 | |
| 0043231 | |
| 0005578 | |
| 0016787 | |
| 0046872 | |
| 0008237 | |
| 0043200 | |
| 0034097 |
| IPI ID | IPI00027782 |
|---|---|
| IPI00789207 | |
| IPI00123511 | |
| IPI00324928 |
| Mouse chromosome position | 9 1.0 cM |
|---|
| Homologene ID | 20545 |
|---|
| MGI ID | 97010 |
|---|
| Rat chromosome position | 8q11 |
|---|
| RGD ID | 621317 |
|---|