| URN | urn:agi-llid:5054 |
|---|---|
| Connectivity | 847 |
| Name | SERPINE1 |
| Description | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
| Notes | mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator; may promote neuronal survival [RGD] |
| Pathway | PPARA Targets |
|---|---|
| PPARG Targets | |
| NR1D1 Targets | |
| FXR Targets | |
| ERA Pathway | |
| ERB Targets | |
| GR Targets | |
| PGR Targets | |
| AR Targets | |
| TR3 Targets | |
| SHP1 Targets |
| GO Molecular Function | protein binding |
|---|---|
| protease binding | |
| serine-type endopeptidase activity | |
| endopeptidase inhibitor activity | |
| serine-type endopeptidase inhibitor activity |
| GO Cellular Component | extracellular region |
|---|---|
| soluble fraction | |
| plasma membrane |
| GO Biological Process | regulation of angiogenesis |
|---|---|
| negative regulation of proteolysis | |
| fibrinolysis | |
| regulation of cell proliferation | |
| glucose homeostasis | |
| blood coagulation | |
| chronological cell aging | |
| tissue regeneration | |
| response to reactive oxygen species | |
| wound healing |
| Group | extracellular region |
|---|---|
| soluble fraction | |
| plasma membrane | |
| protein binding | |
| protease binding | |
| serine-type endopeptidase activity | |
| endopeptidase inhibitor activity | |
| serine-type endopeptidase inhibitor activity | |
| regulation of angiogenesis | |
| negative regulation of proteolysis | |
| fibrinolysis | |
| regulation of cell proliferation | |
| glucose homeostasis | |
| blood coagulation | |
| chronological cell aging | |
| tissue regeneration | |
| response to reactive oxygen species | |
| wound healing |
| Hugo ID | 8583 |
|---|
| Human chromosome position | 7q21.3-q22 |
|---|
| LocusLink ID | 5054 |
|---|---|
| 18787 | |
| 24617 |
| Alias | PAI |
|---|---|
| PAI1 | |
| PAI-1 | |
| PLANH1 | |
| plasminogen activator inhibitor-1 | |
| plasminogen activator inhibitor, type I | |
| serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | |
| serine (or cysteine) proteinase inhibitor, clade E, member 1 | |
| nexin, plasminogen activator inhibitor type 1 | |
| Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI) | |
| PAI1A | |
| Planh | |
| Pai1aa | |
| RATPAI1A | |
| Plasminogen activator inhibitor | |
| serine (or cysteine) proteinase inhibitor, member 1 | |
| plasminogen activation inhibitor-1 | |
| Endothelial plasminogen activator inhibitor | |
| nexin 1 | |
| serine (or cysteine)ase inhibitor, clade E, member 1 | |
| serine (or cysteine)ase inhibitor, clade E, member I | |
| serine (or cysteine)ase inhibitor, member 1 | |
| serine (or cysteine)ase inhibitor, member I | |
| serine (or cysteine) proteinase inhibitor, member I | |
| nexin I | |
| serine (or cysteine) proteinase inhibitor, clade E member I | |
| Serpine I | |
| PLANH I | |
| PAI I | |
| LOC231790 | |
| Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) | |
| serine (or cysteine) peptidase inhibitor, clade E, member 1 | |
| serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | |
| Serpine1 | |
| PLANH1s | |
| nexin 1s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 173360 |
|---|
| Swiss-Prot Accession | P05121 |
|---|---|
| P22777 | |
| Q7TPE9 | |
| P20961 |
| Unigene ID | Hs.414795 |
|---|---|
| Hs.713079 | |
| Mm.250422 | |
| Rn.29367 |
| KEGG ID | hsa:5054 |
|---|---|
| rno:24617 |
| Swiss-Prot ID | PAI1_HUMAN |
|---|---|
| PAI1_RAT |
| GO ID | 0002020 |
|---|---|
| 0005515 | |
| 0004252 | |
| 0004867 | |
| 0007596 | |
| 0001300 | |
| 0042730 | |
| 0045765 | |
| 0042127 | |
| 0005576 | |
| 0005886 | |
| 0004866 | |
| 0042593 | |
| 0045861 | |
| 0000302 | |
| 0042246 | |
| 0042060 | |
| 0005625 |
| IPI ID | IPI00007118 |
|---|---|
| IPI00131547 | |
| IPI00204483 |
| Mouse chromosome position | 5 G2 |
|---|
| Homologene ID | 68070 |
|---|
| MGI ID | 97608 |
|---|
| Rat chromosome position | 12q11-q12 |
|---|
| RGD ID | 3249 |
|---|