Protein NR3C1

URN	urn:agi-llid:2908
Connectivity	991
Name	NR3C1
Description	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Notes	The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. [provided by RefSeq]

Pathway	SerotoninR4/6/7 -> NR3C signaling
	Common Regulators
	NR Table
	NR Direct Interactions
	TRA Targets
	PPARG Targets
	LXRA Targets
	ERA Pathway
	GR Targets
	MR Target Genes
	TR3 Targets
	Common Regulators and Small Molecules

Ariadne Ontology	Estrogen-like

GO Molecular Function	transcription regulator activity
	protein binding
	lipid binding
	chromatin binding
	metal ion binding
	zinc ion binding
	steroid binding
	DNA binding
	sequence-specific DNA binding
	transcription factor activity
	double-stranded DNA binding
	protein complex binding
	heat shock protein binding
	protein dimerization activity
	protein homodimerization activity
	protein heterodimerization activity
	receptor tyrosine kinase binding
	NF-kappaB binding
	receptor activity
	ligand-dependent nuclear receptor activity
	steroid hormone receptor activity
	glucocorticoid receptor activity
	transcription activator activity

GO Biological Process	negative regulation of transforming growth factor beta receptor signaling pathway
	anti-apoptosis
	positive regulation of neuron apoptosis
	signal transduction
	regulation of cell proliferation
	regulation of gluconeogenesis
	regulation of glucocorticoid biosynthetic process
	regulation of transcription, DNA-dependent
	glucocorticoid receptor signaling pathway
	glucocorticoid metabolic process
	chromatin modification
	transcription
	transcription from RNA polymerase II promoter
	adrenal gland development
	sex determination
	response to protein stimulus
	response to arsenic

Group	Estrogen-like
	intracellular
	membrane
	cytoplasm
	cytosol
	mitochondrial matrix
	nucleus
	nucleolus
	protein complex
	transcription regulator activity
	protein binding
	lipid binding
	chromatin binding
	metal ion binding
	zinc ion binding
	steroid binding
	DNA binding
	sequence-specific DNA binding
	transcription factor activity
	double-stranded DNA binding
	protein complex binding
	heat shock protein binding
	protein dimerization activity
	protein homodimerization activity
	protein heterodimerization activity
	receptor tyrosine kinase binding
	NF-kappaB binding
	receptor activity
	ligand-dependent nuclear receptor activity
	steroid hormone receptor activity
	glucocorticoid receptor activity
	transcription activator activity
	negative regulation of transforming growth factor beta receptor signaling pathway
	anti-apoptosis
	positive regulation of neuron apoptosis
	signal transduction
	regulation of cell proliferation
	regulation of gluconeogenesis
	regulation of glucocorticoid biosynthetic process
	regulation of transcription, DNA-dependent
	glucocorticoid receptor signaling pathway
	glucocorticoid metabolic process
	chromatin modification
	transcription
	transcription from RNA polymerase II promoter
	adrenal gland development
	sex determination
	response to protein stimulus
	response to arsenic

Hugo ID	7978

Human chromosome position	5q31.3

Alias	GR
	GCR
	GRL
	GCCR
	nuclear receptor subfamily 3, group C, member 1
	Grl1
	Grl-1
	OTTMUSP00000028420
	OTTMUSP00000028421
	glucocorticoid receptor 1
	glucocorticoid receptor
	Nr3c I
	glucocorticoid receptor, alpha splice form
	Glucocorticoid receptor, lymphocyte
	GCR_HUMAN
	glucocorticoid receptor I
	nuclear receptor subfamily 3, group C, member I
	Nr3c1
	Grl I
	Gralpha
	LOC389335
	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

OMIM ID	138040

Cell Localization	Nucleus

Mouse chromosome position	18 20.0 cM

Homologene ID	30960

MGI ID	95824

Rat chromosome position	18p12

RGD ID	2741