Protein MYC

URN	urn:agi-llid:4609
Connectivity	1565
Name	MYC
Description	v-myc myelocytomatosis viral oncogene homolog (avian)
Notes	The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq]

Pathway	GHR -> ELK-SRF/MYC signaling
	IL2R -> ELK-SRF/MYC signaling
	FibronectinR -> ICAP-1A/MYC signaling
	NCAM1 -> CREB/ELK-SRF/MYC signaling
	Sialophorin -> CTNNB/MYC/TP53 signaling
	NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling
	GFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling
	IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling
	Common Regulators
	PPARA Targets
	PPARG Targets
	RORG Targets
	LXRA Targets
	NR2C1 Targets
	ERA Pathway
	ERB Targets
	GR Targets
	PGR Targets
	LRH1 Targets
	SHP1 Targets

Ariadne Ontology	Oncogenes
	Myc/Mad/Max

GO Molecular Function	transcription regulator activity
	protein binding
	DNA binding
	sequence-specific DNA binding
	transcription factor activity
	double-stranded DNA binding
	protein heterodimerization activity

GO Biological Process	pigmentation
	transcription initiation
	negative regulation of survival gene product expression
	positive regulation of cell proliferation
	induction of apoptosis by intracellular signals
	activation of pro-apoptotic gene products
	positive regulation of B cell apoptosis
	positive regulation of transcription from RNA polymerase II promoter
	regulation of mitotic cell cycle
	regulation of apoptosis
	activation of caspase activity
	regulation of telomere maintenance
	regulation of transcription
	regulation of transcription, DNA-dependent
	regulation of gene expression
	cellular iron ion homeostasis
	positive regulation of catalytic activity
	cell cycle arrest
	release of cytochrome c from mitochondria
	DNA fragmentation involved in apoptosis
	B cell apoptosis
	glucose metabolic process
	transcription
	transcription, DNA-dependent
	transcription from RNA polymerase II promoter
	middle ear morphogenesis
	skeletal system morphogenesis
	protein processing
	pathogenesis
	detection of mechanical stimulus involved in sensory perception of sound
	response to radiation
	response to alkaloid

Group	Oncogenes
	Myc/Mad/Max
	cytoplasm
	nucleus
	nucleolus
	nuclear body
	spindle
	transcription regulator activity
	protein binding
	DNA binding
	sequence-specific DNA binding
	transcription factor activity
	double-stranded DNA binding
	protein heterodimerization activity
	pigmentation
	transcription initiation
	negative regulation of survival gene product expression
	positive regulation of cell proliferation
	induction of apoptosis by intracellular signals
	activation of pro-apoptotic gene products
	positive regulation of B cell apoptosis
	positive regulation of transcription from RNA polymerase II promoter
	regulation of mitotic cell cycle
	regulation of apoptosis
	activation of caspase activity
	regulation of telomere maintenance
	regulation of transcription
	regulation of transcription, DNA-dependent
	regulation of gene expression
	cellular iron ion homeostasis
	positive regulation of catalytic activity
	cell cycle arrest
	release of cytochrome c from mitochondria
	DNA fragmentation involved in apoptosis
	B cell apoptosis
	glucose metabolic process
	transcription
	transcription, DNA-dependent
	transcription from RNA polymerase II promoter
	middle ear morphogenesis
	skeletal system morphogenesis
	protein processing
	pathogenesis
	detection of mechanical stimulus involved in sensory perception of sound
	response to radiation
	response to alkaloid

Hugo ID	7553

Human chromosome position	8q24.21

Alias	MRTL
	c-Myc
	bHLHe39
	myc proto-oncogene protein
	avian myelocytomatosis viral oncogene homolog
	v-myc avian myelocytomatosis viral oncogene homolog
	myc-related translation/localization regulatory factor
	Myc2
	Nird
	Niard
	AU016757
	c-myc proto-oncogene
	mMyc
	RNCMYC
	MGC105490
	myelocytomatosis viral oncogene homolog
	Avian myelocytomatosis viral (v-myc) oncogene homolog
	v-myc myelocytomatosis viral oncogene homolog (avian)
	cMyc
	2900002K07Rik
	RIKEN cDNA 2900002K07 gene
	v-myc myelocytomatosis viral oncogene homolog
	myelocytomatosis oncogene
	Myc oncogene
	Myc transcription factor
	transcription factor Myc
	proto-oncogene Myc
	Myc locus
	C(MYC)
	MYC

OMIM ID	190080
	113970

KEGG ID	mmu:17869
	rno:24577

Cell Localization	Nucleus

Mouse chromosome position	15 32.0 cM

Homologene ID	31092

MGI ID	97250

Rat chromosome position	7q33

RGD ID	3130