Protein NFKBIA

URN	urn:agi-llid:4792
Connectivity	706
Name	NFKBIA
Description	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Notes	NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]

Pathway	CD38 -> NF-kB signaling
	AGER -> NF-kB signaling
	B-cell receptor -> NF-kB signaling
	CD19 -> NF-kB signaling
	GHR -> NF-kB signaling
	ErythropoietinR -> NF-kB signaling
	CSF2R -> NF-kB signaling
	IL12R -> NF-kB/NFATC signaling
	IL7R -> FOXO/NF-kB signaling
	IL15R -> NF-kB/NFATC signaling
	IL1R -> NF-kB signaling
	ThrombinR -> NF-kB signaling
	DopamineR2 -> NF-kB signaling
	PTAFR -> NF-kB signaling
	AdenosineR -> NF-kB signaling
	FibronectinR -> NF-kB signaling
	MacrophageR -> CEBPB/NF-kB signaling
	Notch -> NF-kB signaling
	DDR1 -> NF-kB signaling
	T-cell receptor -> NF-kB signaling
	TNFR -> NF-kB signaling
	EctodysplasinR -> NF-kB signaling
	NGFR -> NF-kB signaling
	TLR3 -> NF-kB signaling
	TLR4/5/7/9 -> NF-kB signaling
	TLR1/2/6 -> NF-kB signaling
	PPARA Targets
	PPARG Targets
	NR1D2 Targets
	RORA Targets
	GR Targets
	PGR Targets
	AR Targets
	TR3 Targets

Ariadne Ontology	NFKBI

GO Molecular Function	nuclear localization sequence binding
	protein complex binding
	identical protein binding
	heat shock protein binding
	ubiquitin protein ligase binding
	NF-kappaB binding

GO Biological Process	negative regulation of Notch signaling pathway
	negative regulation of myeloid cell differentiation
	negative regulation of foam cell differentiation
	negative regulation of lipid metabolic process
	cytoplasmic sequestering of NF-kappaB
	positive regulation of cellular protein metabolic process
	positive regulation of specific transcription from RNA polymerase II promoter
	nucleotide-binding oligomerization domain containing 1 signaling pathway
	nucleotide-binding oligomerization domain containing 2 signaling pathway
	toll-like receptor 4 signaling pathway
	positive regulation of cholesterol transport
	regulation of cell proliferation
	regulation of NF-kappaB import into nucleus
	lipopolysaccharide-mediated signaling pathway
	negative regulation of DNA binding
	apoptosis
	protein import into nucleus, translocation
	interspecies interaction between organisms
	response to lipopolysaccharide
	response to muramyl dipeptide
	response to exogenous dsRNA

Group	NFKBI
	cytoplasm
	I-kappaB-NF-kappaB complex
	cytosol
	nucleus
	protein complex
	nuclear localization sequence binding
	protein complex binding
	identical protein binding
	heat shock protein binding
	ubiquitin protein ligase binding
	NF-kappaB binding
	negative regulation of Notch signaling pathway
	negative regulation of myeloid cell differentiation
	negative regulation of foam cell differentiation
	negative regulation of lipid metabolic process
	cytoplasmic sequestering of NF-kappaB
	positive regulation of cellular protein metabolic process
	positive regulation of specific transcription from RNA polymerase II promoter
	nucleotide-binding oligomerization domain containing 1 signaling pathway
	nucleotide-binding oligomerization domain containing 2 signaling pathway
	toll-like receptor 4 signaling pathway
	positive regulation of cholesterol transport
	regulation of cell proliferation
	regulation of NF-kappaB import into nucleus
	lipopolysaccharide-mediated signaling pathway
	negative regulation of DNA binding
	apoptosis
	protein import into nucleus, translocation
	interspecies interaction between organisms
	response to lipopolysaccharide
	response to muramyl dipeptide
	response to exogenous dsRNA

Hugo ID	7797

Human chromosome position	14q13

Alias	IKBA
	MAD-3
	NFKBI
	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
	IkappaBalpha
	nuclear factor of kappa light chain gene enhancer in B-cells
	AI462015
	I-kappaBalpha
	I(Kappa)B(alpha)
	nuclear factor of kappa light polyp gene enhancer in B-cell 1
	nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha
	RL/IF-1
	Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha
	Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha
	IKBA_HUMAN
	P-I-kappaB-alpha
	Inhibitor of 3000097
	IkappaB/MAD3
	MAD-3/I kappa B alpha
	IkappaB-alpha/MAD3
	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibito
	IkBalpha
	major histocompatibility complex enhance-binding protein MAD3
	Major histocompatibility complex enhancer- binding protein MAD3
	NFKBIA
	Ikappa-Balpha
	RL/IF I
	NF-kappaB inhibitor alpha
	nuclear factor of kappa light polyp gene enhancer in B-cell I
	MAD-III
	nuclear factor of kappa light chain gene enhancer in b-cells inhibitor
	RL/IF-1s
	lkappa-Balpha

OMIM ID	164008
	612132

KEGG ID	mmu:18035
	rno:25493

Cell Localization	Cytoplasm

Mouse chromosome position	12 C1-C3

Homologene ID	7863

MGI ID	104741

Rat chromosome position	6q23

RGD ID	3171