| URN | urn:agi-llid:999 |
|---|---|
| Connectivity | 910 |
| Name | CDH1 |
| Description | cadherin 1, type 1, E-cadherin (epithelial) |
| Notes | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq] |
| Pathway | Common Regulators |
|---|---|
| PPARG Targets | |
| VDR Targets | |
| HNF4A Targets | |
| ERA Pathway | |
| AR Targets |
| Ariadne Ontology | Adherens junction assembly |
|---|
| GO Molecular Function | protein binding |
|---|---|
| calcium ion binding | |
| beta-catenin binding | |
| cell adhesion molecule binding | |
| RPTP-like protein binding | |
| protein phosphatase binding | |
| transcription activator activity |
| GO Cellular Component | membrane |
|---|---|
| apical part of cell | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| Golgi apparatus | |
| actin cytoskeleton | |
| plasma membrane | |
| catenin complex | |
| integral to membrane | |
| cell junction | |
| basolateral plasma membrane | |
| lateral plasma membrane | |
| focal adhesion | |
| cell-cell junction | |
| adherens junction | |
| cell-cell adherens junction |
| GO Biological Process | trophectodermal cell differentiation |
|---|---|
| synaptogenesis | |
| protein homooligomerization | |
| cell adhesion | |
| cell-cell adhesion | |
| homophilic cell adhesion | |
| positive regulation of transcription factor import into nucleus | |
| regulation of caspase activity | |
| neuron projection development | |
| pituitary gland development | |
| protein metabolic process | |
| response to drug | |
| response to organic substance | |
| response to toxin |
| Group | Adherens junction assembly |
|---|---|
| membrane | |
| apical part of cell | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| Golgi apparatus | |
| actin cytoskeleton | |
| plasma membrane | |
| catenin complex | |
| integral to membrane | |
| cell junction | |
| basolateral plasma membrane | |
| lateral plasma membrane | |
| focal adhesion | |
| cell-cell junction | |
| adherens junction | |
| cell-cell adherens junction | |
| protein binding | |
| calcium ion binding | |
| beta-catenin binding | |
| cell adhesion molecule binding | |
| RPTP-like protein binding | |
| protein phosphatase binding | |
| transcription activator activity | |
| trophectodermal cell differentiation | |
| synaptogenesis | |
| protein homooligomerization | |
| cell adhesion | |
| cell-cell adhesion | |
| homophilic cell adhesion | |
| positive regulation of transcription factor import into nucleus | |
| regulation of caspase activity | |
| neuron projection development | |
| pituitary gland development | |
| protein metabolic process | |
| response to drug | |
| response to organic substance | |
| response to toxin |
| Hugo ID | 1748 |
|---|
| Human chromosome position | 16q22.1 |
|---|
| LocusLink ID | 999 |
|---|---|
| 12550 | |
| 83502 |
| Alias | UVO |
|---|---|
| CDHE | |
| ECAD | |
| LCAM | |
| Arc-1 | |
| CD324 | |
| cadherin 1, type 1 | |
| uvomorulin | |
| cell-CAM 120/80 | |
| cadherin 1, E-cadherin (epithelial) | |
| calcium-dependent adhesion protein, epithelial | |
| Um | |
| L-CAM | |
| AA960649 | |
| MGC107495 | |
| cadherin 1 | |
| E-cadherin | |
| OTTMUSP00000022465 | |
| Cdh1 | |
| CAM 120/80 | |
| CAD1_HUMAN | |
| cadherin 1, type 1, E-cadherin (epithelial) | |
| Epithelial cadherin | |
| CAD1 | |
| Arc I | |
| CAD I | |
| Cdh I | |
| e-cadherin (epithelial) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 192090 |
|---|---|
| 137215 |
| Swiss-Prot Accession | A8K1U7 |
|---|---|
| P12830 | |
| Q9UII7 | |
| Q9UII8 | |
| P09803 | |
| Q4KML8 | |
| Q9R0T4 |
| Unigene ID | Hs.461086 |
|---|---|
| Mm.35605 | |
| Rn.1303 |
| KEGG ID | hsa:999 |
|---|---|
| mmu:12550 |
| Swiss-Prot ID | CADH1_HUMAN |
|---|---|
| CADH1_RAT | |
| A8K1U7_HUMAN |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0005509 |
|---|---|
| 0050839 | |
| 0016563 | |
| 0007156 | |
| 0042993 | |
| 0005794 | |
| 0015629 | |
| 0016342 | |
| 0030054 | |
| 0005913 | |
| 0005737 | |
| 0005925 | |
| 0016021 | |
| 0016328 | |
| 0048471 | |
| 0005886 | |
| 0042153 | |
| 0008013 | |
| 0005515 | |
| 0019903 | |
| 0007155 | |
| 0016337 | |
| 0051260 | |
| 0019538 | |
| 0043281 | |
| 0001829 | |
| 0005912 | |
| 0045177 | |
| 0016323 | |
| 0005911 | |
| 0016020 | |
| 0031175 | |
| 0021983 | |
| 0042493 | |
| 0010033 | |
| 0009636 | |
| 0007416 |
| IPI ID | IPI00025861 |
|---|---|
| IPI00744889 | |
| IPI00000513 | |
| IPI00318626 | |
| IPI00206662 |
| Mouse chromosome position | 8 53.3 cM |
|---|
| Homologene ID | 20917 |
|---|
| MGI ID | 88354 |
|---|
| Rat chromosome position | 19q12 |
|---|
| RGD ID | 69279 |
|---|