| URN | urn:agi-llid:4843 |
|---|---|
| Connectivity | 1495 |
| Name | NOS2A |
| Description | nitric oxide synthase 2, inducible |
| Notes | Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq] |
| Pathway | Common Regulators |
|---|---|
| RARA Targets | |
| PPARA Targets | |
| PPARD Targets | |
| PPARG Targets | |
| LXRA Targets | |
| FXR Targets | |
| VDR Targets | |
| HNF4A Targets | |
| ERA Pathway | |
| ERB Targets | |
| GR Targets | |
| Common Regulators and Small Molecules |
| Ariadne Ontology | NO biosyntheis |
|---|---|
| NOS |
| GO Molecular Function | electron carrier activity |
|---|---|
| protein binding | |
| amino acid binding | |
| arginine binding | |
| NADP or NADPH binding | |
| tetrahydrobiopterin binding | |
| FAD binding | |
| FMN binding | |
| metal ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| iron ion binding | |
| heme binding | |
| calmodulin binding | |
| protein homodimerization activity | |
| oxidoreductase activity | |
| nitric-oxide synthase activity | |
| cAMP-dependent protein kinase regulator activity |
| GO Cellular Component | intracellular |
|---|---|
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytosol | |
| cortical cytoskeleton | |
| peroxisome | |
| nucleus |
| GO Biological Process | positive regulation of leukocyte mediated cytotoxicity |
|---|---|
| positive regulation of killing of cells of another organism | |
| signal transduction | |
| regulation of cell proliferation | |
| regulation of insulin secretion | |
| regulation of cellular respiration | |
| G-protein signaling, coupled to cGMP nucleotide second messenger | |
| protein kinase cascade | |
| retinoic acid receptor signaling pathway | |
| cGMP-mediated signaling | |
| regulation of heart contraction | |
| regulation of blood pressure | |
| endothelial cell proliferation | |
| arginine catabolic process | |
| nitric oxide biosynthetic process | |
| superoxide metabolic process | |
| blood vessel remodeling | |
| ovulation from ovarian follicle | |
| innate immune response in mucosa | |
| oxidation reduction | |
| defense response to bacterium | |
| defense response to Gram-negative bacterium | |
| response to hypoxia | |
| inflammatory response |
| Group | NO biosyntheis |
|---|---|
| NOS | |
| intracellular | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytosol | |
| cortical cytoskeleton | |
| peroxisome | |
| nucleus | |
| electron carrier activity | |
| protein binding | |
| amino acid binding | |
| arginine binding | |
| NADP or NADPH binding | |
| tetrahydrobiopterin binding | |
| FAD binding | |
| FMN binding | |
| metal ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| iron ion binding | |
| heme binding | |
| calmodulin binding | |
| protein homodimerization activity | |
| oxidoreductase activity | |
| nitric-oxide synthase activity | |
| cAMP-dependent protein kinase regulator activity | |
| positive regulation of leukocyte mediated cytotoxicity | |
| positive regulation of killing of cells of another organism | |
| signal transduction | |
| regulation of cell proliferation | |
| regulation of insulin secretion | |
| regulation of cellular respiration | |
| G-protein signaling, coupled to cGMP nucleotide second messenger | |
| protein kinase cascade | |
| retinoic acid receptor signaling pathway | |
| cGMP-mediated signaling | |
| regulation of heart contraction | |
| regulation of blood pressure | |
| endothelial cell proliferation | |
| arginine catabolic process | |
| nitric oxide biosynthetic process | |
| superoxide metabolic process | |
| blood vessel remodeling | |
| ovulation from ovarian follicle | |
| innate immune response in mucosa | |
| oxidation reduction | |
| defense response to bacterium | |
| defense response to Gram-negative bacterium | |
| response to hypoxia | |
| inflammatory response |
| Hugo ID | 7873 |
|---|
| Human chromosome position | 17q11.2-q12 |
|---|
| LocusLink ID | 4843 |
|---|---|
| 18126 | |
| 24599 |
| Alias | NOS |
|---|---|
| INOS | |
| NOS2A | |
| HEP-NOS | |
| nitric oxide synthase 2A | |
| NOS, type II | |
| nitric oxide synthase, macrophage | |
| nitric oxide synthase 2A (inducible, hepatocytes) | |
| Nos-2 | |
| i-NOS | |
| NOS-II | |
| RP23-341J22.2 | |
| nitric oxide synthase 2, inducible | |
| OTTMUSP00000000202 | |
| inducible nitric oxide synthase | |
| nitric oxide synthase 2, inducible, macrophage | |
| Hepatocyte NOS | |
| Inducible NOS | |
| nitric oxide synthase 2 | |
| nitric oxide synthase 2A isoform 1 | |
| nitric oxide synthase 2A isoform 2 | |
| Nitric oxide synthase, inducible | |
| NOS2 | |
| nitric oxide synthase 2A isoform I | |
| nitric oxide synthase II | |
| HEP-NOSs | |
| LOC287546 | |
| Nos2a* |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 163730 |
|---|---|
| 145500 | |
| 248310 | |
| 611162 |
| Swiss-Prot Accession | A1L3U5 |
|---|---|
| P35228 | |
| Q9UD42 | |
| Q9UM94 | |
| P29477 | |
| Q06518 | |
| Q62710 | |
| Q6XS76 | |
| Q9R0W4 |
| Unigene ID | Hs.709191 |
|---|---|
| Mm.2893 | |
| Rn.10400 |
| KEGG ID | hsa:4843 |
|---|---|
| mmu:18126 | |
| rno:24599 |
| EC Number | 1.14.13.39 |
|---|
| Swiss-Prot ID | NOS2_HUMAN |
|---|---|
| NOS2_MOUSE | |
| NOS2_RAT | |
| A1L3U5_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0050660 |
|---|---|
| 0010181 | |
| 0050661 | |
| 0034618 | |
| 0008603 | |
| 0005509 | |
| 0005516 | |
| 0009055 | |
| 0020037 | |
| 0004517 | |
| 0016491 | |
| 0042803 | |
| 0034617 | |
| 0008270 | |
| 0007199 | |
| 0006527 | |
| 0001974 | |
| 0050829 | |
| 0001935 | |
| 0002227 | |
| 0006809 | |
| 0055114 | |
| 0051712 | |
| 0001912 | |
| 0007243 | |
| 0008217 | |
| 0043457 | |
| 0008016 | |
| 0050796 | |
| 0001666 | |
| 0048384 | |
| 0007165 | |
| 0006801 | |
| 0030863 | |
| 0005737 | |
| 0005829 | |
| 0005622 | |
| 0005634 | |
| 0048471 | |
| 0005777 | |
| 0005506 | |
| 0046872 | |
| 0005515 | |
| 0042742 | |
| 0006954 | |
| 0001542 | |
| 0042127 | |
| 0016597 | |
| 0019934 |
| IPI ID | IPI00017304 |
|---|---|
| IPI00220339 | |
| IPI00125726 | |
| IPI00363329 | |
| IPI00208047 |
| Mouse chromosome position | 11 45.6 cM |
|---|
| Homologene ID | 55473 |
|---|
| MGI ID | 97361 |
|---|
| Rat chromosome position | 10q25 |
|---|
| RGD ID | 3185 |
|---|