Protein CCND1

URN	urn:agi-llid:595
Connectivity	1267
Name	CCND1
Description	cyclin D1
Notes	The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq]

Ariadne Ontology	Oncogenes
	CycD

GO Molecular Function	protein binding
	protein complex binding
	protein kinase binding
	kinase activity
	protein kinase activity
	cyclin-dependent protein kinase regulator activity

GO Cellular Component	cellular_component
	intracellular
	cytoplasm
	cyclin-dependent protein kinase holoenzyme complex
	cytosol
	nucleus
	nucleoplasm

GO Biological Process	negative regulation of Wnt receptor signaling pathway
	negative regulation of epithelial cell differentiation
	positive regulation of cell proliferation
	positive regulation of cyclin-dependent protein kinase activity
	positive regulation of protein amino acid phosphorylation
	regulation of cell cycle
	Wnt receptor signaling pathway through beta-catenin
	endoplasmic reticulum unfolded protein response
	cell cycle
	cell division
	G1-S transition of mitotic cell cycle
	re-entry into mitotic cell cycle
	fat cell differentiation
	Leydig cell differentiation
	protein amino acid phosphorylation
	organ regeneration
	liver development
	response to X-ray
	response to UV-A
	response to drug
	response to organic substance
	response to steroid hormone stimulus
	response to estrogen stimulus
	response to glucocorticoid stimulus
	response to corticosterone stimulus
	response to estradiol stimulus
	response to calcium ion
	response to magnesium ion
	response to iron ion
	response to vitamin E
	response to ethanol
	response to organic nitrogen
	response to organic cyclic substance

Group	Oncogenes
	CycD
	cellular_component
	intracellular
	cytoplasm
	cyclin-dependent protein kinase holoenzyme complex
	cytosol
	nucleus
	nucleoplasm
	protein binding
	protein complex binding
	protein kinase binding
	kinase activity
	protein kinase activity
	cyclin-dependent protein kinase regulator activity
	negative regulation of Wnt receptor signaling pathway
	negative regulation of epithelial cell differentiation
	positive regulation of cell proliferation
	positive regulation of cyclin-dependent protein kinase activity
	positive regulation of protein amino acid phosphorylation
	regulation of cell cycle
	Wnt receptor signaling pathway through beta-catenin
	endoplasmic reticulum unfolded protein response
	cell cycle
	cell division
	G1-S transition of mitotic cell cycle
	re-entry into mitotic cell cycle
	fat cell differentiation
	Leydig cell differentiation
	protein amino acid phosphorylation
	organ regeneration
	liver development
	response to X-ray
	response to UV-A
	response to drug
	response to organic substance
	response to steroid hormone stimulus
	response to estrogen stimulus
	response to glucocorticoid stimulus
	response to corticosterone stimulus
	response to estradiol stimulus
	response to calcium ion
	response to magnesium ion
	response to iron ion
	response to vitamin E
	response to ethanol
	response to organic nitrogen
	response to organic cyclic substance

Hugo ID	1582

Human chromosome position	11q13

Alias	BCL1
	PRAD1
	U21B31
	D11S287E
	cyclin D1
	B-cell CLL/lymphoma 1
	G1/S-specific cyclin D1
	cD1
	Cyl-1
	bcl-1
	AI327039
	OTTMUSP00000031858
	BCL I
	CGD1
	D1 cyclin
	parathyroid adenomatosis 1
	PRAD1 oncogene
	BCL-1 oncogene
	Ccnd1
	CGD1_HUMAN
	cyclin D
	PRAD1: parathyroid adenomatosis 1
	PRAD1: parathyroid adenomatosis I
	B-cell CLL/lymphoma I
	parathyroid adenomatosis I
	PRAD I
	Ccnd I
	CGD I
	cyclin D1 (PRAD1: parathyroid adenomatosis 1)
	LOC88572
	mgc94339

Cell Localization	Cytoplasm

Mouse chromosome position	7 72.3 cM

Homologene ID	1334

MGI ID	88313

Rat chromosome position	1q42

RGD ID	68384