| URN | urn:agi-llid:6348 |
|---|---|
| Connectivity | 576 |
| Name | CCL3 |
| Description | chemokine (C-C motif) ligand 3 |
| Notes | Macrophage inflammatory protein-1 is a so-called monokine that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988 [PubMed 3279154]). Sherry et al. (1988) [PubMed 3058856] demonstrated 2 protein components of MIP1, called by them alpha and beta.[supplied by OMIM] |
| Pathway | CCR5 -> TP53 signaling |
|---|---|
| CCR1 -> STAT signaling | |
| CCR2/5 -> STAT signaling | |
| PPARG Targets | |
| NURR1 Targets | |
| ERA Pathway | |
| TR3 Targets | |
| NR4A3 Targets |
| Ariadne Ontology | Chemokines |
|---|
| GO Molecular Function | chemoattractant activity |
|---|---|
| chemokine activity | |
| signal transducer activity |
| GO Cellular Component | extracellular region |
|---|---|
| soluble fraction | |
| extracellular space |
| GO Biological Process | signal transduction |
|---|---|
| G-protein coupled receptor protein signaling pathway | |
| regulation of viral genome replication | |
| cellular calcium ion homeostasis | |
| cell motion | |
| cell-cell signaling | |
| cytoskeleton organization | |
| exocytosis | |
| immune response | |
| chemotaxis | |
| inflammatory response |
| Group | Chemokines |
|---|---|
| extracellular region | |
| soluble fraction | |
| extracellular space | |
| chemoattractant activity | |
| chemokine activity | |
| signal transducer activity | |
| signal transduction | |
| G-protein coupled receptor protein signaling pathway | |
| regulation of viral genome replication | |
| cellular calcium ion homeostasis | |
| cell motion | |
| cell-cell signaling | |
| cytoskeleton organization | |
| exocytosis | |
| immune response | |
| chemotaxis | |
| inflammatory response |
| Hugo ID | 10627 |
|---|
| Human chromosome position | 17q11-q21 |
|---|
| LocusLink ID | 6348 |
|---|
| Alias | MIP1A |
|---|---|
| SCYA3 | |
| G0S19-1 | |
| LD78ALPHA | |
| MIP-1-alpha | |
| chemokine (C-C motif) ligand 3 | |
| LD78 alpha beta | |
| small inducible cytokine A3 (homologous to mouse Mip-1a) | |
| Ccl3 | |
| Macrophage inflammatory protein 1-alpha | |
| SIS-beta | |
| small inducible cytokine A3 | |
| Tonsillar lymphocyte LD78 alpha protein | |
| SY03_HUMAN | |
| G0S19 I | |
| macrophage inflammatory protein 1 alpha (small inducible cytokine a3) | |
| PAT 464.1 | |
| SY03 | |
| chemokine (C-C motif) ligand III | |
| AI323804 |
| Organism | Homo sapiens |
|---|
| OMIM ID | 182283 |
|---|---|
| 609423 |
| Swiss-Prot Accession | A0N0R1 |
|---|---|
| P10147 | |
| Q14745 |
| Unigene ID | Hs.514107 |
|---|
| KEGG ID | hsa:6348 |
|---|
| Swiss-Prot ID | CCL3_HUMAN |
|---|---|
| A0N0R1_HUMAN |
| Cell Localization | Extracellular |
|---|
| GO ID | 0042056 |
|---|---|
| 0008009 | |
| 0004871 | |
| 0007186 | |
| 0006928 | |
| 0007267 | |
| 0006874 | |
| 0006935 | |
| 0007010 | |
| 0006887 | |
| 0006955 | |
| 0006954 | |
| 0045069 | |
| 0007165 | |
| 0005576 | |
| 0005615 | |
| 0005625 |
| IPI ID | IPI00019426 |
|---|