| URN | urn:agi-llid:4654 |
|---|---|
| Connectivity | 477 |
| Name | MYOD1 |
| Description | myogenic differentiation 1 |
| Notes | This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq] |
| Pathway | VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling |
|---|---|
| VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling | |
| Notch -> MEF/MYOD signaling | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| IGF1R -> MEF/MYOD/MYOG signaling | |
| TGFBR -> MEF/MYOD/MYOG signaling | |
| PPARD Targets | |
| PPARG Targets | |
| NR2F2 Targets |
| Ariadne Ontology | MYF |
|---|
| GO Molecular Function | transcription regulator activity |
|---|---|
| protein binding | |
| DNA binding | |
| transcription factor activity | |
| RNA polymerase II transcription factor activity, enhancer binding | |
| transcription factor binding | |
| transcription coactivator activity | |
| transcription activator activity |
| GO Cellular Component | nucleus |
|---|---|
| transcription factor complex |
| GO Biological Process | positive regulation of transcription from RNA polymerase II promoter |
|---|---|
| positive regulation of skeletal muscle regeneration | |
| regulation of transcription | |
| regulation of transcription, DNA-dependent | |
| regulation of alternative nuclear mRNA splicing, via spliceosome | |
| cell differentiation | |
| myoblast differentiation | |
| myoblast cell fate determination | |
| striated muscle cell differentiation | |
| transcription | |
| protein amino acid phosphorylation | |
| multicellular organismal development | |
| muscle organ development | |
| skeletal muscle tissue development |
| Group | MYF |
|---|---|
| nucleus | |
| transcription factor complex | |
| transcription regulator activity | |
| protein binding | |
| DNA binding | |
| transcription factor activity | |
| RNA polymerase II transcription factor activity, enhancer binding | |
| transcription factor binding | |
| transcription coactivator activity | |
| transcription activator activity | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of skeletal muscle regeneration | |
| regulation of transcription | |
| regulation of transcription, DNA-dependent | |
| regulation of alternative nuclear mRNA splicing, via spliceosome | |
| cell differentiation | |
| myoblast differentiation | |
| myoblast cell fate determination | |
| striated muscle cell differentiation | |
| transcription | |
| protein amino acid phosphorylation | |
| multicellular organismal development | |
| muscle organ development | |
| skeletal muscle tissue development |
| Hugo ID | 7611 |
|---|
| Human chromosome position | 11p15.4 |
|---|
| LocusLink ID | 4654 |
|---|---|
| 17927 | |
| 337868 |
| Alias | PUM |
|---|---|
| MYF3 | |
| MYOD | |
| bHLHc1 | |
| myogenic differentiation 1 | |
| myogenic factor 3 | |
| myoblast determination protein 1 | |
| Myod-1 | |
| AI503393 | |
| MGC156574 | |
| Myoblast determinating protein I | |
| Myoblast determinating protein 1 | |
| Myoblast determining protein 1 | |
| Myoblast determining protein I | |
| myogenic differentiating 1 | |
| myogenic differentiating I | |
| myogenic differentiation I | |
| MYOD1 | |
| Myogenic factor MYF-3 | |
| MYOD_HUMAN | |
| myogenic factor III | |
| Myoblast determination protein I | |
| Myogenic factor MYF III | |
| MYOD I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 159970 |
|---|
| Swiss-Prot Accession | P15172 |
|---|---|
| Q8C6B1 | |
| P10085 | |
| Q02346 |
| Unigene ID | Hs.181768 |
|---|---|
| Mm.1526 | |
| Rn.9493 |
| KEGG ID | mmu:17927 |
|---|---|
| rno:337868 |
| Swiss-Prot ID | MYOD1_HUMAN |
|---|---|
| MYOD1_RAT | |
| Q8C6B1_MOUSE |
| Cell Localization | Nucleus |
|---|
| GO ID | 0003705 |
|---|---|
| 0003713 | |
| 0008134 | |
| 0030154 | |
| 0007275 | |
| 0007517 | |
| 0007518 | |
| 0045445 | |
| 0043415 | |
| 0045944 | |
| 0006468 | |
| 0000381 | |
| 0007519 | |
| 0051146 | |
| 0005634 | |
| 0005667 | |
| 0003677 | |
| 0005515 | |
| 0016563 | |
| 0003700 | |
| 0030528 | |
| 0045449 | |
| 0006355 | |
| 0006350 |
| IPI ID | IPI00102339 |
|---|---|
| IPI00137502 | |
| IPI00890188 | |
| IPI00205974 |
| Mouse chromosome position | 7 23.5 cM |
|---|
| Homologene ID | 7857 |
|---|
| MGI ID | 97275 |
|---|
| Rat chromosome position | 1q22 |
|---|
| RGD ID | 631429 |
|---|