| URN | urn:agi-llid:1435 |
|---|---|
| Connectivity | 840 |
| Name | CSF1 |
| Description | colony stimulating factor 1 (macrophage) |
| Notes | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | CSF1R -> STAT signaling |
|---|---|
| Common Regulators | |
| PPARG Targets | |
| Common Regulators and Small Molecules |
| Ariadne Ontology | GF |
|---|
| GO Molecular Function | protein binding |
|---|---|
| protein homodimerization activity | |
| growth factor activity | |
| cytokine activity | |
| macrophage colony stimulating factor receptor binding |
| GO Cellular Component | extracellular region |
|---|---|
| membrane | |
| perinuclear region of cytoplasm | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| extracellular space | |
| receptor complex |
| GO Biological Process | positive regulation of cell-matrix adhesion |
|---|---|
| positive regulation of cell proliferation | |
| positive regulation of Ras protein signal transduction | |
| positive regulation of macrophage differentiation | |
| positive regulation of monocyte differentiation | |
| positive regulation of osteoclast differentiation | |
| positive regulation of foam cell differentiation | |
| positive regulation of cell migration | |
| positive regulation of mononuclear cell proliferation | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of odontogenesis of dentine-containing tooth | |
| positive regulation of multicellular organism growth | |
| positive regulation of gene expression | |
| positive regulation of protein kinase activity | |
| regulation of ossification | |
| homeostasis of number of cells within a tissue | |
| monocyte activation | |
| cell differentiation | |
| macrophage differentiation | |
| osteoclast differentiation | |
| multicellular organismal development | |
| ossification | |
| reproductive developmental process | |
| odontogenesis | |
| hemopoiesis |
| Group | GF |
|---|---|
| extracellular region | |
| membrane | |
| perinuclear region of cytoplasm | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| extracellular space | |
| receptor complex | |
| protein binding | |
| protein homodimerization activity | |
| growth factor activity | |
| cytokine activity | |
| macrophage colony stimulating factor receptor binding | |
| positive regulation of cell-matrix adhesion | |
| positive regulation of cell proliferation | |
| positive regulation of Ras protein signal transduction | |
| positive regulation of macrophage differentiation | |
| positive regulation of monocyte differentiation | |
| positive regulation of osteoclast differentiation | |
| positive regulation of foam cell differentiation | |
| positive regulation of cell migration | |
| positive regulation of mononuclear cell proliferation | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of odontogenesis of dentine-containing tooth | |
| positive regulation of multicellular organism growth | |
| positive regulation of gene expression | |
| positive regulation of protein kinase activity | |
| regulation of ossification | |
| homeostasis of number of cells within a tissue | |
| monocyte activation | |
| cell differentiation | |
| macrophage differentiation | |
| osteoclast differentiation | |
| multicellular organismal development | |
| ossification | |
| reproductive developmental process | |
| odontogenesis | |
| hemopoiesis |
| Hugo ID | 2432 |
|---|
| Human chromosome position | 1p21-p13 |
|---|
| LocusLink ID | 1435 |
|---|---|
| 12977 | |
| 78965 |
| Alias | MCSF |
|---|---|
| MGC31930 | |
| colony stimulating factor 1 | |
| OTTHUMP00000013362 | |
| OTTHUMP00000013363 | |
| OTTHUMP00000013364 | |
| macrophage colony stimulating factor | |
| op | |
| Csfm | |
| CSF-1 | |
| M-CSF | |
| C87615 | |
| osteopetrosis | |
| colony-stimulating factor-1 | |
| colony stimulating factor 1 (macrophage) | |
| Macrophage colony stimulating factor-1 | |
| colony stimulation factor 1 isoform b precursor | |
| colony-stimulation factor I | |
| Macrophage colony stimulation factor I | |
| Macrophage colony stimulation factor 1 | |
| colony stimulation factor 1 isoform a precursor | |
| colony stimulation factor 1 isoform c precursor | |
| colony-stimulation factor-1 | |
| Colony-stimulation factor-1 (macrophage) | |
| Macrophage colony stimulation factor | |
| colony stimulating factor 1 isoform a precursor | |
| colony stimulating factor 1 isoform c precursor | |
| Colony-stimulating factor-1 (macrophage) | |
| Csf1 | |
| colony stimulating factor 1 isoform b precursor | |
| colony-stimulating factor I | |
| Macrophage colony stimulating factor I | |
| Csf I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 120420 |
|---|
| Swiss-Prot Accession | A8K6J5 |
|---|---|
| P09603 | |
| Q5VVF2 | |
| Q5VVF3 | |
| P07141 | |
| Q3U395 | |
| Q3TDK0 | |
| Q3TLQ6 | |
| Q3U4F9 | |
| Q6GMN4 | |
| Q8JZQ0 | |
| Q8K408 |
| Unigene ID | Hs.591402 |
|---|---|
| Mm.795 | |
| Rn.83632 |
| KEGG ID | hsa:1435 |
|---|---|
| mmu:12977 |
| EC Number | 2.7.10.1 |
|---|
| Swiss-Prot ID | CSF1_HUMAN |
|---|---|
| CSF1_MOUSE | |
| A8K6J5_HUMAN | |
| Q3U395_MOUSE | |
| Q6GMN4_RAT |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005125 |
|---|---|
| 0005157 | |
| 0042803 | |
| 0030154 | |
| 0030097 | |
| 0042117 | |
| 0030335 | |
| 0001954 | |
| 0032270 | |
| 0010744 | |
| 0010628 | |
| 0045657 | |
| 0032946 | |
| 0045860 | |
| 0003006 | |
| 0005576 | |
| 0005615 | |
| 0016021 | |
| 0048471 | |
| 0005886 | |
| 0043235 | |
| 0008083 | |
| 0005515 | |
| 0048873 | |
| 0046579 | |
| 0008284 | |
| 0045651 | |
| 0040018 | |
| 0042488 | |
| 0045672 | |
| 0030278 | |
| 0016020 | |
| 0030225 | |
| 0007275 | |
| 0042476 | |
| 0001503 | |
| 0030316 | |
| 0005887 |
| IPI ID | IPI00015881 |
|---|---|
| IPI00218201 | |
| IPI00218202 | |
| IPI00125138 | |
| IPI00229812 | |
| IPI00882165 | |
| IPI00882288 | |
| IPI00881800 | |
| IPI00476171 | |
| IPI00202488 | |
| IPI00781806 |
| Mouse chromosome position | 3 51.0 cM |
|---|
| Homologene ID | 7282 |
|---|
| MGI ID | 1339753 |
|---|
| Rat chromosome position | 2q34 |
|---|
| RGD ID | 621063 |
|---|