Protein PDGFRA

URN	urn:agi-llid:5156
Connectivity	278
Name	PDGFRA
Description	platelet-derived growth factor receptor, alpha polypeptide
Notes	This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. [provided by RefSeq]

Pathway	PDGFR -> STAT signaling
	PPARG Targets

Ariadne Ontology	GFR

GO Molecular Function	nucleotide binding
	ATP binding
	protein dimerization activity
	platelet-derived growth factor binding
	protein homodimerization activity
	protein heterodimerization activity
	platelet-derived growth factor receptor binding
	transferase activity
	kinase activity
	protein kinase activity
	protein tyrosine kinase activity
	transmembrane receptor protein tyrosine kinase activity
	vascular endothelial growth factor receptor activity
	platelet-derived growth factor alpha-receptor activity
	receptor activity

GO Biological Process	positive regulation of cell proliferation
	positive regulation of cell migration
	positive regulation of fibroblast proliferation
	positive regulation of DNA replication
	transmembrane receptor protein tyrosine kinase signaling pathway
	platelet-derived growth factor receptor signaling pathway
	cell activation
	extracellular matrix organization
	gliogenesis
	peptidyl-tyrosine phosphorylation
	protein amino acid phosphorylation
	protein amino acid autophosphorylation
	anatomical structure morphogenesis
	palate development
	inner ear development
	organ morphogenesis
	face morphogenesis
	skeletal system morphogenesis
	odontogenesis of dentine-containing tooth
	lung development
	male genitalia development
	in utero embryonic development
	response to organic substance
	response to inorganic substance
	response to hormone stimulus
	response to cytokine stimulus
	response to estrogen stimulus
	response to estradiol stimulus
	response to hyperoxia
	wound healing

Group	GFR
	cellular_component
	membrane
	integral to membrane
	integral to plasma membrane
	nucleotide binding
	ATP binding
	protein dimerization activity
	platelet-derived growth factor binding
	protein homodimerization activity
	protein heterodimerization activity
	platelet-derived growth factor receptor binding
	transferase activity
	kinase activity
	protein kinase activity
	protein tyrosine kinase activity
	transmembrane receptor protein tyrosine kinase activity
	vascular endothelial growth factor receptor activity
	platelet-derived growth factor alpha-receptor activity
	receptor activity
	positive regulation of cell proliferation
	positive regulation of cell migration
	positive regulation of fibroblast proliferation
	positive regulation of DNA replication
	transmembrane receptor protein tyrosine kinase signaling pathway
	platelet-derived growth factor receptor signaling pathway
	cell activation
	extracellular matrix organization
	gliogenesis
	peptidyl-tyrosine phosphorylation
	protein amino acid phosphorylation
	protein amino acid autophosphorylation
	anatomical structure morphogenesis
	palate development
	inner ear development
	organ morphogenesis
	face morphogenesis
	skeletal system morphogenesis
	odontogenesis of dentine-containing tooth
	lung development
	male genitalia development
	in utero embryonic development
	response to organic substance
	response to inorganic substance
	response to hormone stimulus
	response to cytokine stimulus
	response to estrogen stimulus
	response to estradiol stimulus
	response to hyperoxia
	wound healing

Hugo ID	8803

Human chromosome position	4q11-q13

Alias	CD140A
	PDGFR2
	MGC74795
	Rhe-PDGFRA
	platelet-derived growth factor receptor alpha
	FIP1L1/PDGFRA fusion protein
	rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
	Pdgfr-2
	AI115593
	platelet derived growth factor receptor, alpha polypeptide
	PDGF alpha chain
	Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha)
	APDGFR
	PDGFACE
	PDGF alpha R
	PDGFR-A
	Alpha platelet-derived growth factor receptor precursor
	Alpha platelet-derived growth factor receptor precursors
	PDGFACEs
	CD140a antigen
	PDGFalphaR
	PDGFRA
	platelet-derived growth factor receptor alpha precursor
	PGDS_HUMAN
	platelet-derived growth factor receptor
	PDGF receptor alpha
	PDGF-R-alpha
	LOC231312
	LOC289575
	PDGFR alpha
	platelet derived growth factor receptor, alpha
	PDGFR2s

EC Number	2.7.10.1

Cell Localization	Plasma membrane

Mouse chromosome position	5 42.0 cM

Homologene ID	31361

MGI ID	97530

Rat chromosome position	14p11

RGD ID	3284