| URN | urn:agi-llid:596 |
|---|---|
| Connectivity | 1721 |
| Name | BCL2 |
| Description | B-cell CLL/lymphoma 2 |
| Notes | This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq] |
| Pathway | Apoptosis |
|---|---|
| RARA Targets | |
| PPARG Targets | |
| NR2C2 Targets | |
| ERA Pathway | |
| ERB Targets | |
| ERRA Targets | |
| PGR Targets | |
| AR Targets |
| Ariadne Ontology | Oncogenes |
|---|---|
| Bcl |
| GO Molecular Function | protein binding |
|---|---|
| transcription factor binding | |
| protease binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| BH3 domain binding | |
| transcription activator activity |
| GO Cellular Component | intracellular |
|---|---|
| membrane | |
| membrane fraction | |
| microsome | |
| nuclear membrane | |
| endoplasmic reticulum membrane | |
| cytoplasm | |
| calcineurin complex | |
| protein phosphatase type 2A complex | |
| mitochondrion | |
| cytosol | |
| endoplasmic reticulum | |
| mitochondrial membrane | |
| mitochondrial outer membrane | |
| nucleus | |
| integral to membrane | |
| myelin sheath |
| GO Biological Process | growth |
|---|---|
| focal adhesion formation | |
| cell-cell adhesion | |
| regulation of cell-matrix adhesion | |
| negative regulation of cellular pH reduction | |
| negative regulation of calcium ion transport into cytosol | |
| negative regulation of cell proliferation | |
| negative regulation of cell growth | |
| negative regulation of mitochondrial depolarization | |
| negative regulation of mitotic cell cycle | |
| negative regulation of apoptosis | |
| negative regulation of retinal cell programmed cell death | |
| negative regulation of myeloid cell apoptosis | |
| anti-apoptosis | |
| negative regulation of neuron apoptosis | |
| negative regulation of cell migration | |
| negative regulation of osteoblast proliferation | |
| negative regulation of ossification | |
| positive regulation of cell proliferation | |
| positive regulation of cell growth | |
| positive regulation of neuron maturation | |
| activation of pro-apoptotic gene products | |
| positive regulation of skeletal muscle fiber development | |
| positive regulation of melanocyte differentiation | |
| positive regulation of smooth muscle cell migration | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of pigmentation during development | |
| positive regulation of multicellular organism growth | |
| regulation of cell cycle | |
| regulation of programmed cell death | |
| regulation of apoptosis | |
| regulation of glycoprotein biosynthetic process | |
| regulation of pigmentation during development | |
| regulation of protein localization | |
| regulation of calcium ion transport | |
| regulation of gene expression | |
| regulation of protein stability | |
| regulation of nitrogen utilization | |
| regulation of viral genome replication | |
| regulation of mitochondrial membrane permeability | |
| homeostasis of number of cells within a tissue | |
| cellular calcium ion homeostasis | |
| endoplasmic reticulum calcium ion homeostasis | |
| regulation of mitochondrial membrane potential | |
| leukocyte homeostasis | |
| lymphocyte homeostasis | |
| T cell homeostasis | |
| B cell homeostasis | |
| cell growth | |
| regulation of catalytic activity | |
| positive regulation of catalytic activity | |
| regulation of protein heterodimerization activity | |
| regulation of protein homodimerization activity | |
| cell aging | |
| cell death | |
| cell proliferation | |
| actin filament organization | |
| B cell differentiation | |
| B cell proliferation | |
| B cell lineage commitment | |
| T cell differentiation | |
| T cell differentiation in the thymus | |
| T cell lineage commitment | |
| CD8-positive, alpha-beta T cell lineage commitment | |
| G1-S transition of mitotic cell cycle | |
| apoptosis | |
| neuron apoptosis | |
| apoptosis in response to endoplasmic reticulum stress | |
| release of cytochrome c from mitochondria | |
| axonogenesis | |
| axon regeneration | |
| cell morphogenesis | |
| pigment granule organization | |
| mesenchymal cell development | |
| oocyte development | |
| lymphoid progenitor cell differentiation | |
| melanocyte differentiation | |
| oxygen and reactive oxygen species metabolic process | |
| peptidyl-serine phosphorylation | |
| peptidyl-threonine phosphorylation | |
| protein amino acid dephosphorylation | |
| protein polyubiquitination | |
| pigmentation during development | |
| ossification | |
| developmental growth | |
| aging | |
| post-embryonic development | |
| glomerulus development | |
| ureteric bud development | |
| gut morphogenesis | |
| organ morphogenesis | |
| hair follicle morphogenesis | |
| gland morphogenesis | |
| ureteric bud branching | |
| cochlear nucleus development | |
| kidney development | |
| male gonad development | |
| ovarian follicle development | |
| spleen development | |
| thymus development | |
| hemopoiesis | |
| metanephros development | |
| ear development | |
| immune system development | |
| organ growth | |
| defense response to virus | |
| humoral immune response | |
| melanin metabolic process | |
| female pregnancy | |
| behavioral fear response | |
| renal system process | |
| response to chemical stimulus | |
| response to stress | |
| response to external stimulus | |
| response to radiation | |
| response to gamma radiation | |
| response to UV-B | |
| response to heat | |
| response to drug | |
| response to organic substance | |
| response to inorganic substance | |
| response to protein stimulus | |
| response to toxin | |
| response to acid | |
| response to nutrient | |
| response to cytokine stimulus | |
| response to oxidative stress | |
| response to folic acid | |
| response to steroid hormone stimulus | |
| response to peptide hormone stimulus | |
| response to estrogen stimulus | |
| response to glucocorticoid stimulus | |
| response to corticosterone stimulus | |
| response to aluminum ion | |
| response to copper ion | |
| response to iron ion | |
| response to cAMP | |
| response to ethanol | |
| response to organic cyclic substance | |
| response to caffeine | |
| response to nicotine | |
| response to hydrogen peroxide | |
| response to hypoxia |
| Group | Oncogenes |
|---|---|
| Bcl | |
| intracellular | |
| membrane | |
| membrane fraction | |
| microsome | |
| nuclear membrane | |
| endoplasmic reticulum membrane | |
| cytoplasm | |
| calcineurin complex | |
| protein phosphatase type 2A complex | |
| mitochondrion | |
| cytosol | |
| endoplasmic reticulum | |
| mitochondrial membrane | |
| mitochondrial outer membrane | |
| nucleus | |
| integral to membrane | |
| myelin sheath | |
| protein binding | |
| transcription factor binding | |
| protease binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| BH3 domain binding | |
| transcription activator activity | |
| growth | |
| focal adhesion formation | |
| cell-cell adhesion | |
| regulation of cell-matrix adhesion | |
| negative regulation of cellular pH reduction | |
| negative regulation of calcium ion transport into cytosol | |
| negative regulation of cell proliferation | |
| negative regulation of cell growth | |
| negative regulation of mitochondrial depolarization | |
| negative regulation of mitotic cell cycle | |
| negative regulation of apoptosis | |
| negative regulation of retinal cell programmed cell death | |
| negative regulation of myeloid cell apoptosis | |
| anti-apoptosis | |
| negative regulation of neuron apoptosis | |
| negative regulation of cell migration | |
| negative regulation of osteoblast proliferation | |
| negative regulation of ossification | |
| positive regulation of cell proliferation | |
| positive regulation of cell growth | |
| positive regulation of neuron maturation | |
| activation of pro-apoptotic gene products | |
| positive regulation of skeletal muscle fiber development | |
| positive regulation of melanocyte differentiation | |
| positive regulation of smooth muscle cell migration | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of pigmentation during development | |
| positive regulation of multicellular organism growth | |
| regulation of cell cycle | |
| regulation of programmed cell death | |
| regulation of apoptosis | |
| regulation of glycoprotein biosynthetic process | |
| regulation of pigmentation during development | |
| regulation of protein localization | |
| regulation of calcium ion transport | |
| regulation of gene expression | |
| regulation of protein stability | |
| regulation of nitrogen utilization | |
| regulation of viral genome replication | |
| regulation of mitochondrial membrane permeability | |
| homeostasis of number of cells within a tissue | |
| cellular calcium ion homeostasis | |
| endoplasmic reticulum calcium ion homeostasis | |
| regulation of mitochondrial membrane potential | |
| leukocyte homeostasis | |
| lymphocyte homeostasis | |
| T cell homeostasis | |
| B cell homeostasis | |
| cell growth | |
| regulation of catalytic activity | |
| positive regulation of catalytic activity | |
| regulation of protein heterodimerization activity | |
| regulation of protein homodimerization activity | |
| cell aging | |
| cell death | |
| cell proliferation | |
| actin filament organization | |
| B cell differentiation | |
| B cell proliferation | |
| B cell lineage commitment | |
| T cell differentiation | |
| T cell differentiation in the thymus | |
| T cell lineage commitment | |
| CD8-positive, alpha-beta T cell lineage commitment | |
| G1-S transition of mitotic cell cycle | |
| apoptosis | |
| neuron apoptosis | |
| apoptosis in response to endoplasmic reticulum stress | |
| release of cytochrome c from mitochondria | |
| axonogenesis | |
| axon regeneration | |
| cell morphogenesis | |
| pigment granule organization | |
| mesenchymal cell development | |
| oocyte development | |
| lymphoid progenitor cell differentiation | |
| melanocyte differentiation | |
| oxygen and reactive oxygen species metabolic process | |
| peptidyl-serine phosphorylation | |
| peptidyl-threonine phosphorylation | |
| protein amino acid dephosphorylation | |
| protein polyubiquitination | |
| pigmentation during development | |
| ossification | |
| developmental growth | |
| aging | |
| post-embryonic development | |
| glomerulus development | |
| ureteric bud development | |
| gut morphogenesis | |
| organ morphogenesis | |
| hair follicle morphogenesis | |
| gland morphogenesis | |
| ureteric bud branching | |
| cochlear nucleus development | |
| kidney development | |
| male gonad development | |
| ovarian follicle development | |
| spleen development | |
| thymus development | |
| hemopoiesis | |
| metanephros development | |
| ear development | |
| immune system development | |
| organ growth | |
| defense response to virus | |
| humoral immune response | |
| melanin metabolic process | |
| female pregnancy | |
| behavioral fear response | |
| renal system process | |
| response to chemical stimulus | |
| response to stress | |
| response to external stimulus | |
| response to radiation | |
| response to gamma radiation | |
| response to UV-B | |
| response to heat | |
| response to drug | |
| response to organic substance | |
| response to inorganic substance | |
| response to protein stimulus | |
| response to toxin | |
| response to acid | |
| response to nutrient | |
| response to cytokine stimulus | |
| response to oxidative stress | |
| response to folic acid | |
| response to steroid hormone stimulus | |
| response to peptide hormone stimulus | |
| response to estrogen stimulus | |
| response to glucocorticoid stimulus | |
| response to corticosterone stimulus | |
| response to aluminum ion | |
| response to copper ion | |
| response to iron ion | |
| response to cAMP | |
| response to ethanol | |
| response to organic cyclic substance | |
| response to caffeine | |
| response to nicotine | |
| response to hydrogen peroxide | |
| response to hypoxia |
| Hugo ID | 990 |
|---|
| Human chromosome position | 18q21.33 |
|---|
| LocusLink ID | 596 |
|---|---|
| 12043 | |
| 24224 |
| Alias | Bcl-2 |
|---|---|
| B-cell lymphoma protein 2 | |
| OTTHUMP00000163680 | |
| AW986256 | |
| C430015F12Rik | |
| D630044D05Rik | |
| D830018M01Rik | |
| B-cell leukemia/lymphoma 2 | |
| OTTMUSP00000024915 | |
| B-cell CLL/lymphoma 2 | |
| Bcl2-like protein | |
| B cell lymphoma 2 associated oncogene | |
| Apoptosis regulator Bcl-2 | |
| Bcl2 | |
| BCL2_HUMAN | |
| transforming bcl-2, splice form | |
| RIKEN cDNA D830018M01 gene | |
| RIKEN cDNA D630044D05 gene | |
| transforming protein bcl-2, splice form alpha | |
| B-cell CLL/lymphoma II | |
| B-cell leukemia/lymphoma II | |
| B-cell lymphoma protein 2 beta | |
| Apoptosis regulator Bcl II | |
| B-cell lymphoma protein 2 alpha | |
| oncogene B-cell leukemia 2 | |
| LOC100046608 | |
| RIKEN cDNA C430015F12 gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 151430 |
|---|
| Swiss-Prot Accession | P10415 |
|---|---|
| Q96PA0 | |
| Q4VBF6 | |
| Q8BQK4 | |
| Q6NTH7 | |
| P10417 | |
| P49950 | |
| Q7TSN8 | |
| Q9R1B3 |
| Unigene ID | Hs.150749 |
|---|---|
| Mm.257460 | |
| Mm.477249 | |
| Rn.9996 |
| KEGG ID | hsa:596 |
|---|---|
| mmu:12043 | |
| rno:24224 |
| Swiss-Prot ID | BCL2_HUMAN |
|---|---|
| BCL2_RAT | |
| Q4VBF6_MOUSE | |
| Q6NTH7_MOUSE | |
| Q8BQK4_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0051434 |
|---|---|
| 0002020 | |
| 0046982 | |
| 0042803 | |
| 0016563 | |
| 0008134 | |
| 0001782 | |
| 0002326 | |
| 0042100 | |
| 0043375 | |
| 0000082 | |
| 0033077 | |
| 0043029 | |
| 0002360 | |
| 0007015 | |
| 0008633 | |
| 0006916 | |
| 0070059 | |
| 0031103 | |
| 0001662 | |
| 0007569 | |
| 0008219 | |
| 0000902 | |
| 0016337 | |
| 0006874 | |
| 0021747 | |
| 0051607 | |
| 0048589 | |
| 0043583 | |
| 0007565 | |
| 0048041 | |
| 0022612 | |
| 0032835 | |
| 0048547 | |
| 0031069 | |
| 0030097 | |
| 0048873 | |
| 0006959 | |
| 0002520 | |
| 0002320 | |
| 0008584 | |
| 0006582 | |
| 0014031 | |
| 0030308 | |
| 0030336 | |
| 0032848 | |
| 0051902 | |
| 0045930 | |
| 0033033 | |
| 0043524 | |
| 0030279 | |
| 0033689 | |
| 0046671 | |
| 0048599 | |
| 0035265 | |
| 0009887 | |
| 0001541 | |
| 0006800 | |
| 0018105 | |
| 0018107 | |
| 0048753 | |
| 0043085 | |
| 0008284 | |
| 0045636 | |
| 0040018 | |
| 0014042 | |
| 0048087 | |
| 0048743 | |
| 0014911 | |
| 0009791 | |
| 0006470 | |
| 0051726 | |
| 0001952 | |
| 0010468 | |
| 0010559 | |
| 0046902 | |
| 0051881 | |
| 0006808 | |
| 0043497 | |
| 0043496 | |
| 0032880 | |
| 0031647 | |
| 0045069 | |
| 0001836 | |
| 0003014 | |
| 0010224 | |
| 0001101 | |
| 0031000 | |
| 0034097 | |
| 0042493 | |
| 0043627 | |
| 0045471 | |
| 0009605 | |
| 0010332 | |
| 0051384 | |
| 0009408 | |
| 0042542 | |
| 0001666 | |
| 0010035 | |
| 0010039 | |
| 0035094 | |
| 0007584 | |
| 0006979 | |
| 0043434 | |
| 0051789 | |
| 0009314 | |
| 0009636 | |
| 0048536 | |
| 0048538 | |
| 0001658 | |
| 0005955 | |
| 0005737 | |
| 0005829 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0005622 | |
| 0016020 | |
| 0005624 | |
| 0005792 | |
| 0005741 | |
| 0005739 | |
| 0043209 | |
| 0031965 | |
| 0005634 | |
| 0000159 | |
| 0005515 | |
| 0030183 | |
| 0030217 | |
| 0006915 | |
| 0007409 | |
| 0016049 | |
| 0008283 | |
| 0032469 | |
| 0040007 | |
| 0001822 | |
| 0001776 | |
| 0002260 | |
| 0030318 | |
| 0001656 | |
| 0043066 | |
| 0010523 | |
| 0008285 | |
| 0051402 | |
| 0001503 | |
| 0048066 | |
| 0030307 | |
| 0033138 | |
| 0000209 | |
| 0042981 | |
| 0051924 | |
| 0050790 | |
| 0048070 | |
| 0043067 | |
| 0042221 | |
| 0048545 | |
| 0001657 | |
| 0031966 | |
| 0007568 | |
| 0010044 | |
| 0051591 | |
| 0046688 | |
| 0051412 | |
| 0051593 | |
| 0014070 | |
| 0010033 | |
| 0006950 |
| IPI ID | IPI00020961 |
|---|---|
| IPI00217817 | |
| IPI00111518 | |
| IPI00845853 | |
| IPI00227012 | |
| IPI00325212 | |
| IPI00882468 |
| Mouse chromosome position | 1 59.8 cM |
|---|
| Homologene ID | 527 |
|---|
| MGI ID | 88138 |
|---|
| Rat chromosome position | 13p13 |
|---|
| RGD ID | 2199 |
|---|