| URN | urn:agi-llid:581 |
|---|---|
| Connectivity | 1006 |
| Name | BAX |
| Description | BCL2-associated X protein |
| Notes | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq] |
| Pathway | Apoptosis |
|---|---|
| PPARA Targets | |
| PPARG Targets | |
| LXRA Targets | |
| NURR1 Targets | |
| ERA Pathway | |
| ERRA Targets |
| Ariadne Ontology | Tumor suppressors |
|---|---|
| Bid |
| GO Molecular Function | protein binding |
|---|---|
| lipid binding | |
| chaperone binding | |
| heat shock protein binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| BH3 domain binding |
| GO Cellular Component | intracellular |
|---|---|
| membrane | |
| soluble fraction | |
| endoplasmic reticulum membrane | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| cytosolic part | |
| endoplasmic reticulum | |
| mitochondrial membrane | |
| mitochondrial permeability transition pore complex | |
| mitochondrial outer membrane | |
| integral to membrane |
| GO Biological Process | protein homooligomerization |
|---|---|
| negative regulation of anti-apoptosis | |
| negative regulation of cell cycle | |
| negative regulation of cell proliferation | |
| negative regulation of neuron apoptosis | |
| negative regulation of survival gene product expression | |
| negative regulation of fibroblast proliferation | |
| negative regulation of peptidyl-serine phosphorylation | |
| positive regulation of release of sequestered calcium ion into cytosol | |
| positive regulation of calcium ion transport into cytosol | |
| positive regulation of apoptosis | |
| induction of retinal programmed cell death | |
| induction of apoptosis | |
| protein insertion into mitochondrial membrane during induction of apoptosis | |
| induction of apoptosis by intracellular signals | |
| induction of apoptosis by extracellular signals | |
| induction of apoptosis in response to chemical stimulus | |
| positive regulation of neuron apoptosis | |
| positive regulation of apoptosis involved in mammary gland involution | |
| positive regulation of B cell apoptosis | |
| positive regulation of pigmentation during development | |
| regulation of cell cycle | |
| regulation of apoptosis | |
| regulation of caspase activity | |
| activation of caspase activity | |
| activation of caspase activity by cytochrome c | |
| regulation of mammary gland epithelial cell proliferation | |
| regulation of nitrogen utilization | |
| regulation of mitochondrial membrane permeability | |
| homeostasis of number of cells | |
| homeostasis of number of cells within a tissue | |
| reduction of endoplasmic reticulum calcium ion concentration | |
| regulation of mitochondrial membrane potential | |
| leukocyte homeostasis | |
| myeloid cell homeostasis | |
| B cell homeostasis | |
| T cell homeostatic proliferation | |
| regulation of protein heterodimerization activity | |
| regulation of protein homodimerization activity | |
| cell proliferation | |
| B cell negative selection | |
| B cell homeostatic proliferation | |
| apoptosis | |
| neuron apoptosis | |
| apoptosis in response to endoplasmic reticulum stress | |
| transformed cell apoptosis | |
| apoptotic mitochondrial changes | |
| mitochondrial fragmentation during apoptosis | |
| release of cytochrome c from mitochondria | |
| release of matrix enzymes from mitochondria | |
| DNA fragmentation involved in apoptosis | |
| nuclear fragmentation during apoptosis | |
| cleavage of lamin | |
| B cell apoptosis | |
| retinal cell programmed cell death | |
| germ cell programmed cell death | |
| neuron migration | |
| Sertoli cell proliferation | |
| mitochondrial fusion | |
| inner mitochondrial membrane organization | |
| outer mitochondrial membrane organization | |
| germ cell development | |
| spermatid differentiation | |
| glycosphingolipid metabolic process | |
| cellular respiration | |
| cellular response to UV | |
| post-embryonic development | |
| cerebral cortex development | |
| retina development in camera-type eye | |
| hypothalamus development | |
| limb morphogenesis | |
| blood vessel remodeling | |
| post-embryonic camera-type eye morphogenesis | |
| odontogenesis of dentine-containing tooth | |
| kidney development | |
| male gonad development | |
| ovarian follicle development | |
| vagina development | |
| nervous system development | |
| development of secondary sexual characteristics | |
| sex differentiation | |
| establishment or maintenance of transmembrane electrochemical gradient | |
| fertilization | |
| spermatogenesis | |
| response to salt stress | |
| response to ionizing radiation | |
| response to gamma radiation | |
| response to drug | |
| response to toxin | |
| response to acid | |
| response to corticosterone stimulus | |
| response to copper ion | |
| response to cocaine | |
| response to wounding | |
| response to axon injury | |
| response to DNA damage stimulus |
| Group | Tumor suppressors |
|---|---|
| Bid | |
| intracellular | |
| membrane | |
| soluble fraction | |
| endoplasmic reticulum membrane | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| cytosolic part | |
| endoplasmic reticulum | |
| mitochondrial membrane | |
| mitochondrial permeability transition pore complex | |
| mitochondrial outer membrane | |
| integral to membrane | |
| protein binding | |
| lipid binding | |
| chaperone binding | |
| heat shock protein binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| BH3 domain binding | |
| protein homooligomerization | |
| negative regulation of anti-apoptosis | |
| negative regulation of cell cycle | |
| negative regulation of cell proliferation | |
| negative regulation of neuron apoptosis | |
| negative regulation of survival gene product expression | |
| negative regulation of fibroblast proliferation | |
| negative regulation of peptidyl-serine phosphorylation | |
| positive regulation of release of sequestered calcium ion into cytosol | |
| positive regulation of calcium ion transport into cytosol | |
| positive regulation of apoptosis | |
| induction of retinal programmed cell death | |
| induction of apoptosis | |
| protein insertion into mitochondrial membrane during induction of apoptosis | |
| induction of apoptosis by intracellular signals | |
| induction of apoptosis by extracellular signals | |
| induction of apoptosis in response to chemical stimulus | |
| positive regulation of neuron apoptosis | |
| positive regulation of apoptosis involved in mammary gland involution | |
| positive regulation of B cell apoptosis | |
| positive regulation of pigmentation during development | |
| regulation of cell cycle | |
| regulation of apoptosis | |
| regulation of caspase activity | |
| activation of caspase activity | |
| activation of caspase activity by cytochrome c | |
| regulation of mammary gland epithelial cell proliferation | |
| regulation of nitrogen utilization | |
| regulation of mitochondrial membrane permeability | |
| homeostasis of number of cells | |
| homeostasis of number of cells within a tissue | |
| reduction of endoplasmic reticulum calcium ion concentration | |
| regulation of mitochondrial membrane potential | |
| leukocyte homeostasis | |
| myeloid cell homeostasis | |
| B cell homeostasis | |
| T cell homeostatic proliferation | |
| regulation of protein heterodimerization activity | |
| regulation of protein homodimerization activity | |
| cell proliferation | |
| B cell negative selection | |
| B cell homeostatic proliferation | |
| apoptosis | |
| neuron apoptosis | |
| apoptosis in response to endoplasmic reticulum stress | |
| transformed cell apoptosis | |
| apoptotic mitochondrial changes | |
| mitochondrial fragmentation during apoptosis | |
| release of cytochrome c from mitochondria | |
| release of matrix enzymes from mitochondria | |
| DNA fragmentation involved in apoptosis | |
| nuclear fragmentation during apoptosis | |
| cleavage of lamin | |
| B cell apoptosis | |
| retinal cell programmed cell death | |
| germ cell programmed cell death | |
| neuron migration | |
| Sertoli cell proliferation | |
| mitochondrial fusion | |
| inner mitochondrial membrane organization | |
| outer mitochondrial membrane organization | |
| germ cell development | |
| spermatid differentiation | |
| glycosphingolipid metabolic process | |
| cellular respiration | |
| cellular response to UV | |
| post-embryonic development | |
| cerebral cortex development | |
| retina development in camera-type eye | |
| hypothalamus development | |
| limb morphogenesis | |
| blood vessel remodeling | |
| post-embryonic camera-type eye morphogenesis | |
| odontogenesis of dentine-containing tooth | |
| kidney development | |
| male gonad development | |
| ovarian follicle development | |
| vagina development | |
| nervous system development | |
| development of secondary sexual characteristics | |
| sex differentiation | |
| establishment or maintenance of transmembrane electrochemical gradient | |
| fertilization | |
| spermatogenesis | |
| response to salt stress | |
| response to ionizing radiation | |
| response to gamma radiation | |
| response to drug | |
| response to toxin | |
| response to acid | |
| response to corticosterone stimulus | |
| response to copper ion | |
| response to cocaine | |
| response to wounding | |
| response to axon injury | |
| response to DNA damage stimulus |
| Hugo ID | 959 |
|---|
| Human chromosome position | 19q13.3-q13.4 |
|---|
| LocusLink ID | 581 |
|---|---|
| 12028 | |
| 24887 |
| Alias | BCL2L4 |
|---|---|
| BCL2-associated X protein | |
| apoptosis regulator BAX | |
| bax zeta | |
| Bax | |
| BAXB | |
| DXS1283E | |
| BAX protein, cytoplasmic isoform gamma | |
| rBax alpha | |
| BAX protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600040 |
|---|
| Swiss-Prot Accession | Q07812 |
|---|---|
| Q9NYG7 | |
| O95074 | |
| Q5ZPJ0 | |
| Q5ZPJ1 | |
| Q8WXU1 | |
| Q9UEI8 | |
| Q07813 | |
| Q544Z6 | |
| Q3TXJ7 | |
| Q8K3J2 | |
| Q8VHY7 | |
| Q9R0K9 | |
| Q63690 | |
| Q9JKL3 |
| Unigene ID | Hs.624291 |
|---|---|
| Mm.19904 | |
| Rn.10668 |
| KEGG ID | hsa:581 |
|---|---|
| mmu:12028 | |
| rno:24887 |
| Swiss-Prot ID | BAX_HUMAN |
|---|---|
| BAX_MOUSE | |
| BAX_RAT | |
| Q9NYG7_HUMAN | |
| Q544Z6_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0051434 |
|---|---|
| 0008289 | |
| 0046982 | |
| 0042803 | |
| 0001783 | |
| 0006309 | |
| 0008635 | |
| 0006922 | |
| 0010248 | |
| 0008624 | |
| 0008629 | |
| 0046674 | |
| 0043653 | |
| 0008053 | |
| 0045786 | |
| 0008634 | |
| 0030264 | |
| 0043525 | |
| 0051260 | |
| 0042981 | |
| 0051881 | |
| 0043497 | |
| 0043496 | |
| 0001836 | |
| 0032976 | |
| 0009636 | |
| 0006927 | |
| 0005737 | |
| 0005829 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0005741 | |
| 0005757 | |
| 0005739 | |
| 0005515 | |
| 0001782 | |
| 0002358 | |
| 0002352 | |
| 0060011 | |
| 0001777 | |
| 0006919 | |
| 0006915 | |
| 0070059 | |
| 0008637 | |
| 0001974 | |
| 0008283 | |
| 0034644 | |
| 0021987 | |
| 0045136 | |
| 0009566 | |
| 0007281 | |
| 0035234 | |
| 0006687 | |
| 0048872 | |
| 0048873 | |
| 0021854 | |
| 0006917 | |
| 0031558 | |
| 0001822 | |
| 0001776 | |
| 0035108 | |
| 0008584 | |
| 0002262 | |
| 0019987 | |
| 0008285 | |
| 0048147 | |
| 0043524 | |
| 0033137 | |
| 0007399 | |
| 0051402 | |
| 0001764 | |
| 0042475 | |
| 0001541 | |
| 0002904 | |
| 0043065 | |
| 0060058 | |
| 0010524 | |
| 0048087 | |
| 0051281 | |
| 0048597 | |
| 0009791 | |
| 0001844 | |
| 0032471 | |
| 0043281 | |
| 0051726 | |
| 0033599 | |
| 0046902 | |
| 0006808 | |
| 0006974 | |
| 0001101 | |
| 0048678 | |
| 0010332 | |
| 0010212 | |
| 0009651 | |
| 0009611 | |
| 0060041 | |
| 0046666 | |
| 0007548 | |
| 0048515 | |
| 0007283 | |
| 0060068 | |
| 0044445 | |
| 0005622 | |
| 0031966 | |
| 0005625 | |
| 0051087 | |
| 0031072 | |
| 0045333 | |
| 0007007 | |
| 0007008 | |
| 0042220 | |
| 0046688 | |
| 0051412 | |
| 0042493 |
| IPI ID | IPI00443773 |
|---|---|
| IPI00444945 | |
| IPI00445503 | |
| IPI00439209 | |
| IPI00071059 | |
| IPI00885178 | |
| IPI00885203 | |
| IPI00845474 | |
| IPI00120684 | |
| IPI00211129 |
| Mouse chromosome position | 7 23.0 cM |
|---|
| Homologene ID | 7242 |
|---|
| MGI ID | 99702 |
|---|
| Rat chromosome position | 1q31.2 |
|---|
| RGD ID | 2192 |
|---|