| URN | urn:agi-llid:4360 |
|---|---|
| Connectivity | 156 |
| Name | MRC1 |
| Description | mannose receptor, C type 1 |
| Notes | The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. This gene is in close proximity to MRC1L1. The gene loci including this gene, MRC1L1, as well as LOC340843 and LOC340893, consist of two nearly identical, tandemly linked genomic regions, which are thought to be a part of a duplicated region. [provided by RefSeq] |
| Pathway | PPARA Targets |
|---|---|
| PPARG Targets | |
| ERA Pathway |
| Ariadne Ontology | Scavenger receptor |
|---|
| GO Molecular Function | binding |
|---|---|
| sugar binding | |
| mannose binding | |
| calcium ion binding | |
| receptor activity | |
| transmembrane receptor activity |
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| cytoplasm | |
| Golgi apparatus | |
| nucleus | |
| nucleolus | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | endocytosis |
|---|---|
| receptor-mediated endocytosis |
| Group | Scavenger receptor |
|---|---|
| cell surface | |
| membrane | |
| cytoplasm | |
| Golgi apparatus | |
| nucleus | |
| nucleolus | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| binding | |
| sugar binding | |
| mannose binding | |
| calcium ion binding | |
| receptor activity | |
| transmembrane receptor activity | |
| endocytosis | |
| receptor-mediated endocytosis |
| Hugo ID | 7228 |
|---|
| Human chromosome position | 10p12.33 |
|---|
| LocusLink ID | 4360 |
|---|---|
| 17533 | |
| 291327 |
| Alias | MMR |
|---|---|
| CD206 | |
| CLEC13D | |
| RP11-457D2.1 | |
| mannose receptor C type 1 | |
| OTTHUMP00000019245 | |
| OTTHUMP00000045206 | |
| macrophage mannose receptor | |
| MR | |
| AW259686 | |
| mannose receptor, C type 1 | |
| OTTMUSP00000012205 | |
| macrophage mannose receptor 1 | |
| mannose receptor precursors | |
| Macrophage mannose receptor precursors | |
| Mrc1 | |
| CD206 antigen | |
| mannose receptor C type 1 precursor | |
| mannose receptor precursor | |
| MANR | |
| mannose receptor, C type | |
| MANR_HUMAN | |
| Macrophage mannose receptor precursor | |
| Mrc I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 153618 |
|---|
| Swiss-Prot Accession | P22897 |
|---|---|
| Q5VSJ2 | |
| Q0Z8D6 | |
| Q2HZ94 | |
| Q61830 |
| Unigene ID | Hs.75182 |
|---|---|
| Mm.2019 | |
| Rn.9197 |
| KEGG ID | mmu:17533 |
|---|---|
| rno:291327 |
| Swiss-Prot ID | MRC1_HUMAN |
|---|---|
| Q5VSJ2_HUMAN | |
| Q2HZ94_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0005488 |
|---|---|
| 0005509 | |
| 0005537 | |
| 0004872 | |
| 0005529 | |
| 0006898 | |
| 0005794 | |
| 0005737 | |
| 0005887 | |
| 0005730 | |
| 0005634 | |
| 0005886 | |
| 0004888 | |
| 0006897 | |
| 0009986 | |
| 0016021 | |
| 0016020 |
| IPI ID | IPI00027848 |
|---|---|
| IPI00883599 | |
| IPI00126186 | |
| IPI00869708 |
| Mouse chromosome position | 2 5.0 cM |
|---|
| MGI ID | 97142 |
|---|
| Rat chromosome position | 17q12.3 |
|---|
| RGD ID | 1309353 |
|---|