| URN | urn:agi-llid:6647 |
|---|---|
| Connectivity | 513 |
| Name | SOD1 |
| Description | superoxide dismutase 1, soluble |
| Notes | The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq] |
| Pathway | TRB Targets |
|---|---|
| PPARA Targets | |
| PPARD Targets | |
| PPARG Targets | |
| ERA Pathway |
| Ariadne Ontology | ROS catabolism |
|---|
| GO Molecular Function | antioxidant activity |
|---|---|
| protein binding | |
| metal ion binding | |
| copper ion binding | |
| zinc ion binding | |
| chaperone binding | |
| protein phosphatase 2B binding | |
| protein homodimerization activity | |
| oxidoreductase activity | |
| superoxide dismutase activity |
| GO Cellular Component | cell soma |
|---|---|
| dendrite cytoplasm | |
| cytoplasm | |
| mitochondrion | |
| cytoplasmic vesicle | |
| cytosol | |
| peroxisome | |
| mitochondrial matrix | |
| nucleus | |
| plasma membrane | |
| extracellular space | |
| extracellular matrix | |
| protein complex |
| GO Biological Process | negative regulation of apoptosis |
|---|---|
| anti-apoptosis | |
| negative regulation of neuron apoptosis | |
| negative regulation of cholesterol biosynthetic process | |
| relaxation of vascular smooth muscle | |
| positive regulation of apoptosis | |
| positive regulation of cytokine production | |
| regulation of T cell differentiation in the thymus | |
| regulation of protein kinase activity | |
| activation of MAPK activity | |
| regulation of organ growth | |
| regulation of multicellular organism growth | |
| regulation of blood pressure | |
| muscle maintenance | |
| retina homeostasis | |
| cellular iron ion homeostasis | |
| regulation of mitochondrial membrane potential | |
| myelin maintenance in the peripheral nervous system | |
| myeloid cell homeostasis | |
| positive regulation of catalytic activity | |
| cell aging | |
| transmission of nerve impulse | |
| DNA fragmentation involved in apoptosis | |
| auditory receptor cell stereocilium organization | |
| neurofilament cytoskeleton organization | |
| hydrogen peroxide biosynthetic process | |
| double-strand break repair | |
| glutathione metabolic process | |
| superoxide metabolic process | |
| removal of superoxide radicals | |
| superoxide release | |
| embryo implantation | |
| aging | |
| placenta development | |
| ovarian follicle development | |
| thymus development | |
| oxidation reduction | |
| heart contraction | |
| sensory perception of sound | |
| spermatogenesis | |
| locomotory behavior | |
| response to heat | |
| response to drug | |
| response to oxidative stress | |
| response to copper ion | |
| response to ethanol | |
| response to reactive oxygen species | |
| response to hydrogen peroxide | |
| response to superoxide | |
| response to nutrient levels | |
| response to axon injury |
| Group | ROS catabolism |
|---|---|
| cell soma | |
| dendrite cytoplasm | |
| cytoplasm | |
| mitochondrion | |
| cytoplasmic vesicle | |
| cytosol | |
| peroxisome | |
| mitochondrial matrix | |
| nucleus | |
| plasma membrane | |
| extracellular space | |
| extracellular matrix | |
| protein complex | |
| antioxidant activity | |
| protein binding | |
| metal ion binding | |
| copper ion binding | |
| zinc ion binding | |
| chaperone binding | |
| protein phosphatase 2B binding | |
| protein homodimerization activity | |
| oxidoreductase activity | |
| superoxide dismutase activity | |
| negative regulation of apoptosis | |
| anti-apoptosis | |
| negative regulation of neuron apoptosis | |
| negative regulation of cholesterol biosynthetic process | |
| relaxation of vascular smooth muscle | |
| positive regulation of apoptosis | |
| positive regulation of cytokine production | |
| regulation of T cell differentiation in the thymus | |
| regulation of protein kinase activity | |
| activation of MAPK activity | |
| regulation of organ growth | |
| regulation of multicellular organism growth | |
| regulation of blood pressure | |
| muscle maintenance | |
| retina homeostasis | |
| cellular iron ion homeostasis | |
| regulation of mitochondrial membrane potential | |
| myelin maintenance in the peripheral nervous system | |
| myeloid cell homeostasis | |
| positive regulation of catalytic activity | |
| cell aging | |
| transmission of nerve impulse | |
| DNA fragmentation involved in apoptosis | |
| auditory receptor cell stereocilium organization | |
| neurofilament cytoskeleton organization | |
| hydrogen peroxide biosynthetic process | |
| double-strand break repair | |
| glutathione metabolic process | |
| superoxide metabolic process | |
| removal of superoxide radicals | |
| superoxide release | |
| embryo implantation | |
| aging | |
| placenta development | |
| ovarian follicle development | |
| thymus development | |
| oxidation reduction | |
| heart contraction | |
| sensory perception of sound | |
| spermatogenesis | |
| locomotory behavior | |
| response to heat | |
| response to drug | |
| response to oxidative stress | |
| response to copper ion | |
| response to ethanol | |
| response to reactive oxygen species | |
| response to hydrogen peroxide | |
| response to superoxide | |
| response to nutrient levels | |
| response to axon injury |
| Hugo ID | 11179 |
|---|
| Human chromosome position | 21q22.1 |
|---|
| LocusLink ID | 6647 |
|---|---|
| 20655 | |
| 667310 | |
| 24786 |
| Alias | ALS |
|---|---|
| SOD | |
| ALS1 | |
| IPOA | |
| homodimer | |
| superoxide dismutase 1, soluble | |
| SOD, soluble | |
| indophenoloxidase A | |
| Cu/Zn superoxide dismutase | |
| superoxide dismutase, cystolic | |
| Ipo1 | |
| SODC | |
| Ipo-1 | |
| Sod-1 | |
| CuZnSOD | |
| Cu/Zn-SOD | |
| MGC107553 | |
| B430204E11Rik | |
| Cu(2+)-Zn2+ superoxide dismutase | |
| Superoxide dismutase-1, soluble | |
| Sod I | |
| superoxide dismutase 1 | |
| Ipo I | |
| ALS I | |
| RIKEN cDNA B430204E11 gene | |
| CuZnSODs | |
| superoxide dismutase (aa 120-154) | |
| Sod1 | |
| Superoxide dimutase 1, soluble | |
| Superoxide dismutase (Cu-Zn) | |
| superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | |
| soluble Superoxide dismutase I | |
| soluble Superoxide dismutase-1 | |
| superoxide dimutase 1 | |
| Cu /Zn superoxide dismutase | |
| EG667310 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 147450 |
|---|---|
| 105400 |
| Swiss-Prot Accession | P00441 |
|---|---|
| P08228 | |
| Q8C355 | |
| P07632 | |
| Q6LDS4 |
| Unigene ID | Hs.443914 |
|---|---|
| Mm.276325 | |
| Mm.466779 | |
| Mm.439880 | |
| Rn.6059 |
| KEGG ID | hsa:6647 |
|---|---|
| mmu:20655 | |
| mmu:667310 | |
| rno:24786 |
| EC Number | 1.15.1.1 |
|---|
| Swiss-Prot ID | SODC_HUMAN |
|---|---|
| SODC_MOUSE | |
| SODC_RAT |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0016209 |
|---|---|
| 0051087 | |
| 0005507 | |
| 0046872 | |
| 0016491 | |
| 0042803 | |
| 0030346 | |
| 0004784 | |
| 0008270 | |
| 0006309 | |
| 0000187 | |
| 0006916 | |
| 0060088 | |
| 0007569 | |
| 0006879 | |
| 0006302 | |
| 0007566 | |
| 0006749 | |
| 0060047 | |
| 0050665 | |
| 0007626 | |
| 0046716 | |
| 0032287 | |
| 0002262 | |
| 0045541 | |
| 0043524 | |
| 0060052 | |
| 0001541 | |
| 0055114 | |
| 0001890 | |
| 0043065 | |
| 0043085 | |
| 0001819 | |
| 0033081 | |
| 0008217 | |
| 0051881 | |
| 0040014 | |
| 0046620 | |
| 0045859 | |
| 0060087 | |
| 0019430 | |
| 0048678 | |
| 0046688 | |
| 0042493 | |
| 0045471 | |
| 0009408 | |
| 0042542 | |
| 0031667 | |
| 0000303 | |
| 0001895 | |
| 0007605 | |
| 0007283 | |
| 0042554 | |
| 0048538 | |
| 0019226 | |
| 0043025 | |
| 0005737 | |
| 0031410 | |
| 0005829 | |
| 0032839 | |
| 0031012 | |
| 0005615 | |
| 0005759 | |
| 0005739 | |
| 0005634 | |
| 0005777 | |
| 0005886 | |
| 0043234 | |
| 0005515 | |
| 0007568 | |
| 0043066 | |
| 0006979 | |
| 0000302 | |
| 0006801 |
| IPI ID | IPI00218733 |
|---|---|
| IPI00789078 | |
| IPI00130589 | |
| IPI00458744 | |
| IPI00231643 | |
| IPI00778383 |
| Mouse chromosome position | 16 61.0 cM |
|---|---|
| 6 C1 |
| MGI ID | 98351 |
|---|---|
| 3647296 |
| Rat chromosome position | 11q11 |
|---|
| RGD ID | 3731 |
|---|