| URN | urn:agi-llid:9370 |
|---|---|
| Connectivity | 707 |
| Name | ADIPOQ |
| Description | adiponectin, C1Q and collagen domain containing |
| Notes | This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. [provided by RefSeq] |
| Pathway | Common Regulators |
|---|---|
| PPARA Targets | |
| PPARG Targets | |
| FXR Targets | |
| GR Targets | |
| NR5A1 Targets | |
| LRH1 Targets | |
| Common Regulators and Small Molecules |
| Ariadne Ontology | Adiponectin |
|---|
| GO Molecular Function | molecular_function |
|---|---|
| protein binding | |
| eukaryotic cell surface binding | |
| receptor binding | |
| protein homodimerization activity | |
| hormone activity | |
| cytokine activity |
| GO Cellular Component | extracellular region |
|---|---|
| endoplasmic reticulum | |
| extracellular space |
| GO Biological Process | protein homooligomerization |
|---|---|
| negative regulation of heterotypic cell-cell adhesion | |
| negative regulation of hormone secretion | |
| negative regulation of tumor necrosis factor-mediated signaling pathway | |
| negative regulation of I-kappaB kinase-NF-kappaB cascade | |
| negative regulation of fat cell differentiation | |
| negative regulation of macrophage differentiation | |
| negative regulation of granulocyte differentiation | |
| negative regulation of foam cell differentiation | |
| negative regulation of phagocytosis | |
| negative regulation of gluconeogenesis | |
| negative regulation of low-density lipoprotein receptor biosynthetic process | |
| negative regulation of tumor necrosis factor production | |
| negative regulation of inflammatory response | |
| positive regulation of signal transduction | |
| positive regulation of protein kinase A signaling cascade | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of myeloid cell apoptosis | |
| positive regulation of fatty acid metabolic process | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of glucose import | |
| positive regulation of cholesterol transport | |
| regulation of protein kinase cascade | |
| adiponectin-mediated signaling pathway | |
| positive regulation of blood pressure | |
| membrane depolarization | |
| membrane hyperpolarization | |
| glucose homeostasis | |
| low-density lipoprotein particle clearance | |
| cell differentiation | |
| brown fat cell differentiation | |
| generation of precursor metabolites and energy | |
| glucose metabolic process | |
| fatty acid beta-oxidation | |
| fatty acid oxidation | |
| response to drug | |
| response to nutrient | |
| response to tumor necrosis factor | |
| response to glucocorticoid stimulus | |
| response to ethanol | |
| response to sucrose stimulus | |
| response to glucose stimulus | |
| response to hypoxia |
| Group | Adiponectin |
|---|---|
| extracellular region | |
| endoplasmic reticulum | |
| extracellular space | |
| molecular_function | |
| protein binding | |
| eukaryotic cell surface binding | |
| receptor binding | |
| protein homodimerization activity | |
| hormone activity | |
| cytokine activity | |
| protein homooligomerization | |
| negative regulation of heterotypic cell-cell adhesion | |
| negative regulation of hormone secretion | |
| negative regulation of tumor necrosis factor-mediated signaling pathway | |
| negative regulation of I-kappaB kinase-NF-kappaB cascade | |
| negative regulation of fat cell differentiation | |
| negative regulation of macrophage differentiation | |
| negative regulation of granulocyte differentiation | |
| negative regulation of foam cell differentiation | |
| negative regulation of phagocytosis | |
| negative regulation of gluconeogenesis | |
| negative regulation of low-density lipoprotein receptor biosynthetic process | |
| negative regulation of tumor necrosis factor production | |
| negative regulation of inflammatory response | |
| positive regulation of signal transduction | |
| positive regulation of protein kinase A signaling cascade | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of myeloid cell apoptosis | |
| positive regulation of fatty acid metabolic process | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of glucose import | |
| positive regulation of cholesterol transport | |
| regulation of protein kinase cascade | |
| adiponectin-mediated signaling pathway | |
| positive regulation of blood pressure | |
| membrane depolarization | |
| membrane hyperpolarization | |
| glucose homeostasis | |
| low-density lipoprotein particle clearance | |
| cell differentiation | |
| brown fat cell differentiation | |
| generation of precursor metabolites and energy | |
| glucose metabolic process | |
| fatty acid beta-oxidation | |
| fatty acid oxidation | |
| response to drug | |
| response to nutrient | |
| response to tumor necrosis factor | |
| response to glucocorticoid stimulus | |
| response to ethanol | |
| response to sucrose stimulus | |
| response to glucose stimulus | |
| response to hypoxia |
| Hugo ID | 13633 |
|---|
| Human chromosome position | 3q27 |
|---|
| LocusLink ID | 9370 |
|---|---|
| 11450 | |
| 246253 |
| Alias | ACDC |
|---|---|
| ADPN | |
| APM1 | |
| APM-1 | |
| GBP28 | |
| ACRP30 | |
| ADIPQTL1 | |
| adiponectin | |
| gelatin-binding protein 28 | |
| adipose most abundant gene transcript 1 | |
| adipocyte, C1Q and collagen domain containing | |
| adipocyte, C1Q and collagen domain-containing | |
| APN | |
| 30kDa | |
| adipo | |
| adiponectin, C1Q and collagen domain containing | |
| adipocyte complement related protein | |
| adipocyte complement related protein of 30 kDa | |
| ADIPOQ | |
| 30kDa adipocyte complement protein | |
| APM I | |
| adipose most abundant gene transcript I | |
| adipocyte-specific secretory protein | |
| ACRP30s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605441 |
|---|---|
| 612556 |
| Swiss-Prot Accession | A8K660 |
|---|---|
| Q15848 | |
| Q6GTX4 | |
| Q60994 | |
| Q8BRW2 | |
| Q8K3R4 |
| Unigene ID | Hs.80485 |
|---|---|
| Mm.3969 | |
| Rn.24299 |
| KEGG ID | mmu:11450 |
|---|---|
| rno:246253 |
| Swiss-Prot ID | ADIPO_HUMAN |
|---|---|
| A8K660_HUMAN | |
| Q6GTX4_MOUSE | |
| Q8K3R4_RAT |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005125 |
|---|---|
| 0043499 | |
| 0005179 | |
| 0042803 | |
| 0006635 | |
| 0006091 | |
| 0042593 | |
| 0006006 | |
| 0034383 | |
| 0043124 | |
| 0045599 | |
| 0010745 | |
| 0045721 | |
| 0030853 | |
| 0034115 | |
| 0050728 | |
| 0045715 | |
| 0050765 | |
| 0032720 | |
| 0010804 | |
| 0043123 | |
| 0032270 | |
| 0032376 | |
| 0045923 | |
| 0046326 | |
| 0033034 | |
| 0010739 | |
| 0009967 | |
| 0051260 | |
| 0009749 | |
| 0034612 | |
| 0005783 | |
| 0005576 | |
| 0005615 | |
| 0005515 | |
| 0005102 | |
| 0050873 | |
| 0019395 | |
| 0003674 | |
| 0033211 | |
| 0030154 | |
| 0051899 | |
| 0060081 | |
| 0046888 | |
| 0045650 | |
| 0045777 | |
| 0050731 | |
| 0010627 | |
| 0042493 | |
| 0045471 | |
| 0051384 | |
| 0001666 | |
| 0007584 | |
| 0009744 |
| IPI ID | IPI00020019 |
|---|---|
| IPI00796550 | |
| IPI00311383 | |
| IPI00742301 | |
| IPI00202515 |
| Mouse chromosome position | 16 16.0 cM |
|---|
| Homologene ID | 3525 |
|---|
| MGI ID | 106675 |
|---|
| Rat chromosome position | 11q23 |
|---|
| RGD ID | 628748 |
|---|