| URN | urn:agi-llid:6774 |
|---|---|
| Connectivity | 1435 |
| Name | STAT3 |
| Description | signal transducer and activator of transcription 3 (acute-phase response factor) |
| Notes | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq] |
| Pathway | MPL -> STAT signaling |
|---|---|
| ErythropoietinR -> STAT signaling | |
| OncostatinR -> STAT3 signaling | |
| CSF3R -> STAT signaling | |
| CNTFR -> STAT3 signaling | |
| IFNGR -> STAT signaling | |
| LeptinR -> STAT signaling | |
| CSF2R -> STAT signaling | |
| ProlactinR -> STAT signaling | |
| IFNAR -> STAT signaling | |
| GHR -> STAT signaling | |
| IL21R -> STAT signaling | |
| IL15R -> STAT signaling | |
| IL10R -> STAT signaling | |
| IL7R -> STAT signaling | |
| IL2R -> STAT signaling | |
| IL5R -> STAT signaling | |
| IL22R -> STAT3 signaling | |
| IL6R -> STAT signaling | |
| IL11R -> STAT3 signalling | |
| IL13R -> STAT signaling | |
| IL12R -> STAT signaling | |
| IL9R -> STAT signaling | |
| IL31R -> STAT signaling | |
| IL3R -> STAT signaling | |
| IL1R -> STAT3 signaling | |
| CCR1 -> STAT signaling | |
| CCR2/5 -> STAT signaling | |
| CXCR4 -> STAT signaling | |
| PTAFR -> STAT3 signaling | |
| AdrenergicRa -> STAT3 signaling | |
| VasopressinR1 -> STAT signaling | |
| CholecystokininR -> STAT signaling | |
| OpioidR -> CREB/ELK-SRF/STAT3 signaling | |
| BradykininR -> STAT3 signaling | |
| SerotoninR2 -> STAT3 signaling | |
| AngiotensinR -> STAT signaling | |
| AdrenergicRb -> STAT3 signaling | |
| VasopressinR2 -> STAT signaling | |
| ICAM2 -> CTNNB/FOXO/STAT3 signaling | |
| PECAM -> STAT signaling | |
| ALK -> STAT signaling | |
| EphrinR -> STAT signaling | |
| AngiopoietinR -> STAT signaling | |
| HGFR -> STAT signaling | |
| EGFR/ERBB -> STAT signaling | |
| FGFR3 -> STAT signaling | |
| FGFR1 -> STAT signaling | |
| CSF1R -> STAT signaling | |
| KIT -> STAT signaling | |
| PDGFR -> STAT signaling | |
| VEGFR -> STAT signaling | |
| InsulinR -> STAT signaling | |
| IGF1R -> STAT signaling | |
| T-cell receptor -> STAT signaling | |
| CD2 -> STAT signaling | |
| TNFRSF5 -> STAT signaling | |
| TNFRSF1A -> STAT signaling | |
| Common Regulators | |
| PPARG Targets | |
| Common Regulators and Small Molecules |
| Ariadne Ontology | STAT |
|---|
| GO Molecular Function | protein binding |
|---|---|
| calcium ion binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription factor activity | |
| protein dimerization activity | |
| transcription factor binding | |
| protein kinase binding | |
| signal transducer activity | |
| hematopoietin-interferon-class (D200-domain) cytokine receptor signal transducer activity | |
| transcription activator activity |
| GO Cellular Component | cytoplasm |
|---|---|
| nucleus | |
| nucleolus | |
| plasma membrane |
| GO Biological Process | negative regulation of transcription from RNA polymerase II promoter |
|---|---|
| positive regulation of transcription from RNA polymerase II promoter | |
| signal transduction | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| cytokine-mediated signaling pathway | |
| interleukin-6-mediated signaling pathway | |
| JAK-STAT cascade involved in growth hormone signaling pathway | |
| JAK-STAT cascade | |
| regulation of multicellular organism growth | |
| temperature homeostasis | |
| glucose homeostasis | |
| cell motion | |
| eye photoreceptor cell differentiation | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| cellular response to hormone stimulus | |
| nervous system development | |
| interspecies interaction between organisms | |
| sexual reproduction | |
| eating behavior | |
| response to drug | |
| response to organic substance | |
| response to cytokine stimulus | |
| response to peptide hormone stimulus | |
| response to estradiol stimulus | |
| response to ethanol | |
| response to organic cyclic substance | |
| acute-phase response |
| Group | STAT |
|---|---|
| cytoplasm | |
| nucleus | |
| nucleolus | |
| plasma membrane | |
| protein binding | |
| calcium ion binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription factor activity | |
| protein dimerization activity | |
| transcription factor binding | |
| protein kinase binding | |
| signal transducer activity | |
| hematopoietin-interferon-class (D200-domain) cytokine receptor signal transducer activity | |
| transcription activator activity | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of transcription from RNA polymerase II promoter | |
| signal transduction | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| cytokine-mediated signaling pathway | |
| interleukin-6-mediated signaling pathway | |
| JAK-STAT cascade involved in growth hormone signaling pathway | |
| JAK-STAT cascade | |
| regulation of multicellular organism growth | |
| temperature homeostasis | |
| glucose homeostasis | |
| cell motion | |
| eye photoreceptor cell differentiation | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| cellular response to hormone stimulus | |
| nervous system development | |
| interspecies interaction between organisms | |
| sexual reproduction | |
| eating behavior | |
| response to drug | |
| response to organic substance | |
| response to cytokine stimulus | |
| response to peptide hormone stimulus | |
| response to estradiol stimulus | |
| response to ethanol | |
| response to organic cyclic substance | |
| acute-phase response |
| Hugo ID | 11364 |
|---|
| Human chromosome position | 17q21.31 |
|---|
| LocusLink ID | 6774 |
|---|---|
| 20848 | |
| 25125 |
| Alias | APRF |
|---|---|
| HIES | |
| FLJ20882 | |
| MGC16063 | |
| signal transducer and activator of transcription 3 | |
| DNA-binding protein APRF | |
| acute-phase response factor | |
| AW109958 | |
| 1110034C02Rik | |
| RP23-279L23.5 | |
| OTTMUSP00000002052 | |
| OTTMUSP00000002053 | |
| acute phase response factor | |
| MGC93551 | |
| Acute-phase response factor | |
| signal transducer and activator of transcription 3 (acute-phase response fa | |
| signal transducer and activator of transcription 3 isoform 1 | |
| signal transducer and activator of transcription 3 isoform 2 | |
| Stat3 | |
| signal transducer and activator of transcription 3 isoform I | |
| signal transducer and activator of transcription 3 isoform II | |
| Signal transducer and activator of transcription III | |
| Hyper-IgE syndrome protein | |
| Hyper-IgE syndrome gene | |
| RIKEN cDNA 1110034C02 gene | |
| signal transducer and activator of transcription 3 (acute-phase response factor) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 102582 |
|---|---|
| 147060 |
| Swiss-Prot Accession | P40763 |
|---|---|
| Q9BXH2 | |
| P42227 | |
| Q6GU23 | |
| A2A5D1 | |
| Q3U5Q4 | |
| Q3U6S9 | |
| Q3ULI4 | |
| Q8CFJ6 | |
| Q99ML3 | |
| P52631 |
| Unigene ID | Hs.463059 |
|---|---|
| Mm.249934 | |
| Rn.10247 |
| KEGG ID | mmu:20848 |
|---|---|
| rno:25125 |
| Swiss-Prot ID | STAT3_HUMAN |
|---|---|
| STAT3_MOUSE | |
| STAT3_RAT | |
| A2A5D1_MOUSE | |
| B7ZC17_MOUSE | |
| Q6GU23_MOUSE |
| Cell Localization | Nucleus |
|---|
| GO ID | 0005509 |
|---|---|
| 0005062 | |
| 0004871 | |
| 0003700 | |
| 0008134 | |
| 0060397 | |
| 0006928 | |
| 0032870 | |
| 0070102 | |
| 0044419 | |
| 0000122 | |
| 0007399 | |
| 0032355 | |
| 0007165 | |
| 0005737 | |
| 0005730 | |
| 0005634 | |
| 0003677 | |
| 0005515 | |
| 0046983 | |
| 0019901 | |
| 0043565 | |
| 0016563 | |
| 0006953 | |
| 0019221 | |
| 0042755 | |
| 0001754 | |
| 0042593 | |
| 0045944 | |
| 0040014 | |
| 0006357 | |
| 0006355 | |
| 0019953 | |
| 0001659 | |
| 0006350 | |
| 0006366 | |
| 0005886 | |
| 0007259 | |
| 0034097 | |
| 0042493 | |
| 0045471 | |
| 0014070 | |
| 0010033 | |
| 0043434 |
| IPI ID | IPI00784414 |
|---|---|
| IPI00306436 | |
| IPI00412752 | |
| IPI00228955 | |
| IPI00227814 | |
| IPI00753792 | |
| IPI00208224 |
| Mouse chromosome position | 11 60.5 cM |
|---|
| Homologene ID | 7960 |
|---|
| MGI ID | 103038 |
|---|
| Rat chromosome position | 10q32.1 |
|---|
| RGD ID | 3772 |
|---|