Protein IL12B

URN	urn:agi-llid:3593
Connectivity	478
Name	IL12B
Description	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
Notes	This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq]

Ariadne Ontology	Cytokine

GO Molecular Function	protein binding
	cytokine receptor activity
	interleukin-12 alpha subunit binding
	protein homodimerization activity
	protein heterodimerization activity
	cytokine activity
	interleukin-12 receptor binding
	signal transducer activity

GO Biological Process	positive regulation of cell adhesion
	negative regulation of smooth muscle cell proliferation
	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
	positive regulation of natural killer cell activation
	positive regulation of T cell proliferation
	positive regulation of activated T cell proliferation
	positive regulation of smooth muscle cell apoptosis
	positive regulation of interferon-gamma biosynthetic process
	positive regulation of interferon-gamma production
	regulation of cytokine biosynthetic process
	cell surface receptor linked signal transduction
	natural killer cell activation during immune response
	T-helper cell differentiation
	cell cycle arrest
	cell migration
	T-helper 1 type immune response
	sensory perception of pain
	response to UV-B

Group	Cytokine
	extracellular region
	membrane
	extracellular space
	interleukin-12 complex
	protein binding
	cytokine receptor activity
	interleukin-12 alpha subunit binding
	protein homodimerization activity
	protein heterodimerization activity
	cytokine activity
	interleukin-12 receptor binding
	signal transducer activity
	positive regulation of cell adhesion
	negative regulation of smooth muscle cell proliferation
	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
	positive regulation of natural killer cell activation
	positive regulation of T cell proliferation
	positive regulation of activated T cell proliferation
	positive regulation of smooth muscle cell apoptosis
	positive regulation of interferon-gamma biosynthetic process
	positive regulation of interferon-gamma production
	regulation of cytokine biosynthetic process
	cell surface receptor linked signal transduction
	natural killer cell activation during immune response
	T-helper cell differentiation
	cell cycle arrest
	cell migration
	T-helper 1 type immune response
	sensory perception of pain
	response to UV-B

Hugo ID	5970

Human chromosome position	5q31.1-q33.1

Alias	CLMF
	NKSF
	CLMF2
	NKSF2
	IL-12B
	interleukin 12B
	IL12, subunit p40
	OTTHUMP00000160820
	interleukin 12, p40
	interleukin-12 beta chain
	natural killer cell stimulatory factor, 40 kD subunit
	p40
	Il12p40
	Il-12p40
	RP23-388G23.1
	IL-12 p40
	IL-23 subunit p40
	OTTMUSP00000005619
	Il12
	interleukin-12 p40
	Cytotoxic lymphocyte maturating factor 40 kDa subunit
	cytotoxic lymphocyte maturating factor 2
	cytotoxic lymphocyte maturating factor II
	cytotoxic lymphocyte maturating factor 2, p40
	I12B_MOUSE
	Interleukin IL12 beta
	Cytotoxic lymphocyte maturation factor 40 kDa subunit
	cytotoxic lymphocyte maturation factor 2
	cytotoxic lymphocyte maturation factor 2, p40
	I12B
	interkeukin-12 beta chain
	Interleukin IL12AB
	Interleukin-12 beta
	NK cell stimulatory factor chain 2
	I12B_HUMAN
	IL23, subuint p
	cytotoxic lymphocyte maturation factor 2, p
	NK cell stimulatory factor chain II
	IL23, subuint p40
	natural killer cell stimulatory factor-2
	cytotoxic lymphocyte maturation factor II
	natural killer cell stimulatory factor II
	Il12b
	bronchial hyperresponsiveness 1
	Bronchial hyperresponsiveness-1 (bronchial asthma)
	bronchial hyperresponsiveness I
	BHR I
	BHR1
	natural killer cell stimulatory factor
	IL-12-specific subunit p40
	Interleukin 12
	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
	CLMF P40

KEGG ID	hsa:3593
	mmu:16160

Cell Localization	Extracellular

Mouse chromosome position	11 19.0 cM

Homologene ID	1648

MGI ID	96540

Rat chromosome position	10q21

RGD ID	628704